Ceramidase Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
2-Amino-4- (trifluoromethyl) phenol Quick inquiry Where to buy Suppliers range | 2-Amino-4- (trifluoromethyl) phenol is used in the studies on the structure activity relationship of benzoxazolone carboxamides as potent acid ceramidase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 454-81-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H6F3NO, Molecular Weight: 177.12. US Biological Life Sciences. | Worldwide |
ARN14974 Quick inquiry Where to buy Suppliers range | ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase with IC50 of 79 nM. It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. Synonyms: Acid Ceramidase Inhibitor 17a; ARN-14974; ARN 14974; Acid Ceramidase Inhibitor 17a. Grades: ≥95%. CAS No. 1644158-57-5. Molecular formula: C24H21FN2O3. Mole weight: 404.4. | |
ARN14988 Quick inquiry Where to buy Suppliers range | ARN14988 can normalize ceramide levels and concomitantly sensitize proliferative melanoma cells to the cytotoxic actions of various antitumoral agents. ARN14988 is a potent inhibitor of acid ceramidase with IC50 of 12.8 nM for the human enzyme. ARN14988 also reduces growth of A375 with EC50s of 41.8 μM and G361 with EC50s of 67.7 μM. Synonyms: ARN 14988; ARN-14988. Grades: ≥98%. CAS No. 1502027-70-4. Molecular formula: C16H24ClN3O5. Mole weight: 373.83. | |
C18 L-erythro Ceramide (d18:1/18:0) Quick inquiry Where to buy Suppliers range | C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. It can inhibit rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 8.8 μM. Synonyms: L-erythro Cer(d18:1/18:0); L-erythro Ceramide (d18:1/18:0); N-octadecanoyl-L-erythro-sphingosine. Grades: ≥98%. CAS No. 252039-52-4. Molecular formula: C36H71NO3. Mole weight: 565.95. | |
C18 L-threo Ceramide (d18:1/18:0) Quick inquiry Where to buy Suppliers range | C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 16.8 μM. Synonyms: N-octadecanoyl-L-threo-sphingosine; L-threo Cer(d18:1/18:0); L-threo Ceramide (d18:1/18:0). Grades: ≥98%. CAS No. 95037-06-2. Molecular formula: C36H71NO3. Mole weight: 565.95. | |
Ceranib 1 Quick inquiry Where to buy Suppliers range | Ceranib 1 is a ceramidase inhibitor. It inhibits proliferation in SKOV3 ovarian carcinoma cells. It decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells and induces accumulation of ceramide species. It is a useful research chemical and has an antiproliferative effect. Synonyms: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone; 6-Methyl-3-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone. Grades: ≥98% by HPLC. CAS No. 328076-61-5. Molecular formula: C26H21NO3. Mole weight: 395.45. | |
Ceranib-2 Quick inquiry Where to buy Suppliers range | Ceranib-2 is an inhibitor of cellular ceramidase activity, which can inhibit ceramidase activity with IC50 of 28 μM in SKOV3 cells. It can catalyze the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Ceranib-2 decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and inhibits cell proliferation. Grades: ≥98%. CAS No. 1402830-75-4. Molecular formula: C25H19NO3. Mole weight: 381.4. | |
Ceranib-2 (3- (3- (4-methoxyphenyl) acryloyl) -4-phenylquinolin-2 (1H) -one, Ceranib 2, Ceranib2) Quick inquiry Where to buy Suppliers range | A cell-permeable, potent inhibitor of ceramidase (IC50=28mM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50=730nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50mg/kg) without affecting the total body weight. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?, Molecular Weight: 381.4. US Biological Life Sciences. | Worldwide |
D-erythro-MAPP Quick inquiry Where to buy Suppliers range | D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase. It increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner. Synonyms: (1S,2R-D-erythro-2-N-myristoylamino)-1-phenyl-1-propanol; D-e-MAPP; MAPP, D-erythro. Grades: ≥98%. CAS No. 143492-38-0. Molecular formula: C23H39NO2. Mole weight: 361.6. | |
D-NMAPPD Quick inquiry Where to buy Suppliers range | D-NMAPPD is an inhibitor of ceramidase. It induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner but doesn't have effect on viability of rat hepatocytes, Kupffer cells, or sinusoidal endothelial cells when used at a concentration of 100 mM. It also increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells. Synonyms: (1R,2R)-B13; CAY10466; N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide. Grades: ≥98%. CAS No. 35922-06-6. Molecular formula: C23H38N2O5. Mole weight: 422.6. |