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| Product | Description | |
|---|---|---|
| ceramidase | Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1-phosphate (S1P). Group: Enzymes. Synonyms: acylsphingosine deacylase; glycosphingolipid ceramide deacylase. Enzyme Commission Number: EC 3.5.1.23. CAS No. 37289-06-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4413; ceramidase; EC 3.5.1.23; 37289-06-8; acylsphingosine deacylase; glycosphingolipid ceramide deacylase. Cat No: EXWM-4413. |  |
| Acid Ceramidase-IN-2 | Acid Ceramidase-IN-2 (compound 1) is an acid ceramidase inhibitor with potentially antiproliferative and cytostatic activities. Moreover, human acid ceramidase is overexpressed in prostate cancer cells, indicating potential anti-tumor effect of Acid Ceramidase-IN-2. And Acid Ceramidase-IN-2 hydrolysis can be inhibited by 3 a-ketoamides GT85, GT98 and GT99 inhibits in vitro [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1005497-03-9. Pack Sizes: 1 mg. Product ID: HY-153396. |  |
| galactosyl galactosyl glucosyl ceramidase | This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. Group: Enzymes. Synonyms: trihexosyl ceramide galactosidase; ceramide trihexosidase; ceramidetrihexoside α-galactosidase; trihexosylceramide α-galactosidase; ceramidetrihexosidase. Enzyme Commission Number: EC 3.2.1.47. CAS No. 9023-1-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3910; galactosyl galactosyl glucosyl ceramidase; EC 3.2.1.47; 9023-01-2; trihexosyl ceramide galactosidase; ceramide trihexosidase; ceramidetrihexoside α-galactosidase; trihexosylceramide α-galactosidase; ceramidetrihexosidase. Cat No: EXWM-3910. | |
| 2-Amino-4- (trifluoromethyl) phenol | 2-Amino-4- (trifluoromethyl) phenol is used in the studies on the structure activity relationship of benzoxazolone carboxamides as potent acid ceramidase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 454-81-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H6F3NO, Molecular Weight: 177.12. US Biological Life Sciences. |  Worldwide |
| ARN14974 | ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase with IC50 of 79 nM. It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. Synonyms: Acid Ceramidase Inhibitor 17a; ARN-14974; ARN 14974; Acid Ceramidase Inhibitor 17a. Grades: ≥95%. CAS No. 1644158-57-5. Molecular formula: C24H21FN2O3. Mole weight: 404.4. |  |
| ARN14988 | ARN14988 can normalize ceramide levels and concomitantly sensitize proliferative melanoma cells to the cytotoxic actions of various antitumoral agents. ARN14988 is a potent inhibitor of acid ceramidase with IC50 of 12.8 nM for the human enzyme. ARN14988 also reduces growth of A375 with EC50s of 41.8 μM and G361 with EC50s of 67.7 μM. Synonyms: ARN 14988; ARN-14988. Grades: ≥98%. CAS No. 1502027-70-4. Molecular formula: C16H24ClN3O5. Mole weight: 373.83. | |
| C18 L-erythro Ceramide (d18:1/18:0) | C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. It can inhibit rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 8.8 μM. Synonyms: L-erythro Cer(d18:1/18:0); L-erythro Ceramide (d18:1/18:0); N-octadecanoyl-L-erythro-sphingosine. Grades: ≥98%. CAS No. 252039-52-4. Molecular formula: C36H71NO3. Mole weight: 565.95. | |
| C18 L-threo Ceramide (d18:1/18:0) | C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 16.8 μM. Synonyms: N-octadecanoyl-L-threo-sphingosine; L-threo Cer(d18:1/18:0); L-threo Ceramide (d18:1/18:0). Grades: ≥98%. CAS No. 95037-06-2. Molecular formula: C36H71NO3. Mole weight: 565.95. | |
| Carmofur | Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC 50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease ( Mpro ), fatty acid amide hydrolase ( FAAH ) and N-acylethanolamine acid amidase ( NAAA ). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HCFU. CAS No. 61422-45-5. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0182. | |
| Ceranib 1 | Ceranib 1 is a ceramidase inhibitor. It inhibits proliferation in SKOV3 ovarian carcinoma cells. It decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells and induces accumulation of ceramide species. It is a useful research chemical and has an antiproliferative effect. Synonyms: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone; 6-Methyl-3-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone. Grades: ≥98% by HPLC. CAS No. 328076-61-5. Molecular formula: C26H21NO3. Mole weight: 395.45. | |
| Ceranib-2 | Ceranib-2 is an inhibitor of cellular ceramidase activity, which can inhibit ceramidase activity with IC50 of 28 μM in SKOV3 cells. It can catalyze the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Ceranib-2 decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and inhibits cell proliferation. Grades: ≥98%. CAS No. 1402830-75-4. Molecular formula: C25H19NO3. Mole weight: 381.4. | |
| Ceranib-2 (3- (3- (4-methoxyphenyl) acryloyl) -4-phenylquinolin-2 (1H) -one, Ceranib 2, Ceranib2) | A cell-permeable, potent inhibitor of ceramidase (IC50=28mM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50=730nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50mg/kg) without affecting the total body weight. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?, Molecular Weight: 381.4. US Biological Life Sciences. | Worldwide |
| D-erythro-MAPP | D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC 50 of 1-5 μM in vitro [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-e-MAPP. CAS No. 143492-38-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-137422. | |
| D-erythro-MAPP | D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase. It increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner. Synonyms: (1S,2R-D-erythro-2-N-myristoylamino)-1-phenyl-1-propanol; D-e-MAPP; MAPP, D-erythro. Grades: ≥98%. CAS No. 143492-38-0. Molecular formula: C23H39NO2. Mole weight: 361.6. | |
| D-NMAPPD | D-NMAPPD is an inhibitor of ceramidase. It induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner but doesn't have effect on viability of rat hepatocytes, Kupffer cells, or sinusoidal endothelial cells when used at a concentration of 100 mM. It also increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells. Synonyms: (1R,2R)-B13; CAY10466; N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide. Grades: ≥98%. CAS No. 35922-06-6. Molecular formula: C23H38N2O5. Mole weight: 422.6. | |
| glycosphingolipid deacylase | Does not act on sphingolipids such as ceramide. Not identical with EC 3.5.1.23 ceramidase. Group: Enzymes. Synonyms: glycosphingolipid ceramide deacylase. Enzyme Commission Number: EC 3.5.1.69. CAS No. 122544-53-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4459; glycosphingolipid deacylase; EC 3.5.1.69; 122544-53-0; glycosphingolipid ceramide deacylase. Cat No: EXWM-4459. | |
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