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| Product | Description | |
|---|---|---|
| cGMP-dependent protein kinase | CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase. Group: Enzymes. Synonyms: 3':5'-cyclic GMP-dependent protein kinase; cGMP-dependent protein kinase Iβ; guanosine 3':5'-cyclic monophosphate-dependent protein kinase; PKG; PKG 1α; PKG 1β; PKG II; STK23. Enzyme Commission Number: EC 2.7.11.12. CAS No. 141588-27-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3131; cGMP-dependent protein kinase; EC 2.7.11.12; 141588-27-4; 3':5'-cyclic GMP-dependent protein kinase; cGMP-dependent protein kinase Iβ; guanosine 3':5'-cyclic monophosphate-dependent protein kinase; PKG; PKG 1α; PKG 1β; PKG II; STK23. Cat No: EXWM-3131. |  |
| 2-Biotin-14-cGMP | 2-Biotin-14-cGMP, a potent cyclic nucleotide derivative, serves as an exemplary research tool for comprehensively investigating a vast array of signaling pathways intricately interlaced with cGMP. Furthermore, the use of this compound serves as a noteworthy means for evaluating the cGMP-dependent protein kinase (PKG) activity pertaining to an extensive spectrum of diseases. Grade: ≥ 98% by HPLC. Molecular formula: C32H49N9O10PS · Na. Mole weight: 805.8. |  |
| 3-Bromo-4-fluoro-benzoic Acid Ethyl Ester | 3-Bromo-4-fluoro-benzoic Acid Ethyl Ester is used to prepare 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents. It is also used to synthesize Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38. Group: Biochemicals. Grades: Highly Purified. CAS No. 23233-33-2. Pack Sizes: 1g, 5g. Molecular Formula: C9H8BrFO2, Molecular Weight: 247.06. US Biological Life Sciences. |  Worldwide |
| 4-N3-PET-8-Br-cGMP | 4-N3-PET-8-Br-cGMP is an analogue used for photoaffinity labelling of cGMP-responsive receptors, and an isozyme-selective activator of cGMP-dependent protein kinase I α and β. Synonyms: β- (4- Azidophenyl)- 1, N2- etheno- 8- bromoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 97% by HPLC. Molecular formula: C18H13BrN8O7P · Na. Mole weight: 587.2. | |
| 8-[(6-Amino)hexyl]-amino-cGMP - DY-751 | DY-751, a mighty stimulator of cGMP-dependent protein kinase (PKG), is a critical element in deciphering PKG's influence on a miscellany of physiological and pathological mechanisms, encompassing but not limited to vasodilation and platelet cohesion. Additionally, DY-751 plays a pivotal role in the exploration of treatments for life-threatening disorders such as hypertension and heart failure. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with DY 751, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C58H76N9O15PS2 (free acid). Mole weight: 1233.46 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - DYQ-660 | 8-[(6-Amino)hexyl]-amino-cGMP - DYQ-660 is an extensively studied compound impeding the functioning of cGMP-dependent protein kinase. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with DYQ 660, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C55H68N9O12PS (free acid). Mole weight: 1110.23 (free acid). | |
| 8-APT-cGMP | 8-APT-cGMP is an isozyme-selective stimulator of cGMP-dependent protein kinase I a with a prenference for type I a over I by a factor of 200. Synonyms: 8- (2- Aminophenylthio)guanosine- 3', 5'- monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 144509-87-5. Molecular formula: C16H16N6O7PS · Na. Mole weight: 490.4. | |
| 8-Br-PET-cGMP | 8-Br-PET-cGMP is a stimulator of isozymes I α and I β of cGMP-dependent protein kinase, which is used as an excellent cyclic nucleotide muscle relaxants. Grade: ≥ 98% by HPLC. CAS No. 144510-04-3. Molecular formula: C18H14BrN5O7P · Na. Mole weight: 546.2. | |
| 8-CPT-cAMP | 8-CPT-cAMP is an activator of cAMP- and cGMP-dependent protein kinase and of Epac. It has an improved membrane permeability, phosphodiesterase stability and selectivity for site B of cAK type II. Uses: Enzyme inhibitors. Synonyms: 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 99% by HPLC. CAS No. 93882-12-3. Molecular formula: C16H14ClN5O6PS · Na. Mole weight: 493.8. | |
| 8-NBD-cGMP | 8-NBD-cGMP is a fluorescent activator of both isozymes I α and I β of cGMP-dependent protein kinase. 8-NBD-cGMP fluoresces strongly in hydrophobic environments. Synonyms: 8-(2-[7-Nitro-4-benzofurazanyl]aminoethylthio)guanosine-3',5'-cyclic monophosphate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 115993-88-9. Molecular formula: C18H17N9NaO10PS. Mole weight: 605.41. | |
| 8-pCPT-cGMP | 8-pCPT-cGMP is a selective activator of cGMP-dependent protein kinase type I α and type II, as well as of cGMP-gated ion channels. It has higher membrane permeability and stability towards many phosphodiesterases. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 99% by HPLC. CAS No. 51239-26-0. Molecular formula: C16H14ClN5O7PS · Na. Mole weight: 509.8. | |
| Antibiotic K252A (Antibiotic SF 2370) | Antibiotic K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. Antibiotic K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. More extensive investigation has demonstrated that while antibiotic K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG). Group: Biochemicals. Grades: Highly Purified. CAS No. 99570-78-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| cGMP Dependent Kinase Inhibitor Peptide | PKG Inhibitor is a competitive inhibitor of cGMP-dependent protein kinase (PKG). It is an analog of a substrate peptide corresponding to a phosphorylation site of histone H2B, and inhibits phosphorylation of intact histones by PKA. Synonyms: cGMP Dependent Kinase Inhibitor Peptide. Grade: >98%. CAS No. 82801-73-8. Molecular formula: C38H74N18O10. Mole weight: 943.12. | |
| Dibutyryl-cGMP sodium | Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [ 3 H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K + channels [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bt2cGMP sodium. CAS No. 51116-00-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-130354. |  |
| DT-2 | DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase ( PKG ). DT-2 inhibits PKG catalyzed phosphorylation (K i : 12.5 nM) [1]. Uses: Scientific research. Group: Peptides. CAS No. 1220985-78-3. Pack Sizes: 1 mg. Product ID: HY-P2692A. | |
| Guanosine-3',5'-cyclic Monophosphate, 8-(2-Aminophenylthio)-Sodium Salt | Guanosine-3',5'-cyclic Monophosphate, 8-(2-Aminophenylthio)-Sodium Salt is an isozyme-selective activator of cGKI α(cGMP-dependent protein kinase 1α) that shows about 200-fold selectivity for the activation of PKG 1α (cGKIα) over PKG 1β (cGKIβ). Applications: A selective activator of cgmp-dependent pk-1a. Group: Coenzymes. CAS No. 144509-87-5. Purity: ≥98%. Mole weight: 490.4. Appearance: Lyophilized. Form: Solid. Guanosine-3',5'-cyclic Monophosphate, 8-(2-Aminophenylthio)-Sodium Salt; 144509-87-5. Cat No: COEC-106. | |
| H-89 dihydrochloride (N-5-isoquinolinesulfonamid e . 2HCl) | Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H20BrN3O2S. 2HCl, Molecular Weight: 519.3. US Biological Life Sciences. | Worldwide |
| H-8 dihydrochloride | Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Myosin light chain kinase (MLCK) inhibitor. Tool to study protein crystal structure-inhibitor interactions. Group: Biochemicals. Grades: Highly Purified. CAS No. 113276-94-1. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H15N3O2S 2HCl. US Biological Life Sciences. | Worldwide |
| HA-100 | HA-100 is a potent protein kinase inhibitor, with IC 50 s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG) , cAMP-dependent protein kinase (PKA) , protein kinase C (PKC) and MLC-kinase , respectively. HA-100 also used as a ROCK inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 84468-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100984. | |
| HA-100 hydrochloride | HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. It exhibits potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases. Uses: Exhibited potent inhibition toward protein kinase c and cyclic nucleotide dependent protein kinases. Synonyms: 1-(5-Isoquinolinesulfonyl)piperazine hydrochloride; 5-(piperazin-1-ylsulfonyl)isoquinoline hydrochloride. CAS No. 141543-63-7. Molecular formula: C13H16ClN3O2S. Mole weight: 313.80. | |
| K-252b | A staurosporine analogue isolated from a nocardiopsis strain; a potent inhibitor of protein kinase C. K-252b exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents; also active against other kinases, notably myosin light chain kinase, camp-dependent protein kinase (PKA), protein kinase C (PKC) and cgmp-dependent protein kinase (PKG). Synonyms: (9r,10s,12s)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid. Grade: >98% by HPLC. CAS No. 99570-78-2. Molecular formula: C26H19N3O5. Mole weight: 453.45. | |
| Kt5823 | KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 126643-37-6. Molecular formula: C29H25N3O5. Mole weight: 495.5259. Purity: >98 %. Product ID: ACM126643376. Alfa Chemistry ISO 9001:2015 Certified. Categories: kt 5823. |  |
| KT5823 | KT5823, a selective the cGMP-dependent protein kinase ( PKG ) inhibitor with an K i value of 0.23 μM, it also inhibits PKA and PKC with K i values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine -related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na + /I - symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 126643-37-6. Pack Sizes: 100 μg. Product ID: HY-N6791. | |
| KT5823 | KT 5823 is a cell-permeable, selective inhibitor of cGMP-dependent protein kinase (PKG) (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells. Uses: Kt5823 induces apoptotic fragmentation of dna. Synonyms: KT 5823; KT-5823; KT5823; 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester. Grade: ≥98%. CAS No. 126643-37-6. Molecular formula: C29H25N3O5. Mole weight: 495.52. | |
| Native Bovine Protein Kinase G Iα | Protein Kinase G 1a is a native isoform of protein kinase G type I (cGK-I) isolated from bovine lung. It is a serine-threonine protein kinase found naturally in high concentrations in the cerebellar Purkinje cells, smooth muscle cells, and human platelets. > 95% (sds-page), buffered aqueous glycerol solution. Group: Enzymes. Synonyms: Protein Kinase G Iα; PKG Iα; cGK Iα; cyclic Guanosine Monophosphate Protein Kinase I α; EC 2.7.1.37; PKG1A; cGMP-dependent protein kinase. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: mol wt 74 kDa (monomer). Stability: -20°C. Form: buffered aqueous glycerol solution. Source: bovine lung. Species: Bovine. Protein Kinase G Iα; PKG Iα; cGK Iα; cyclic Guanosine Monophosphate Protein Kinase I α; EC 2.7.1.37; PKG1A; cGMP-dependent protein kinase. Cat No: NATE-0579. | |
| non-specific serine/threonine protein kinase | This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date. Group: Enzymes. Synonyms: A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; pr. Enzyme Commission Number: EC 2.7.11.1. STK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3128; non-specific serine/threonine protein kinase; EC 2.7.11.1; A-kinase; AP50 kinase; | |
| PKG inhibitor peptide TFA | PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG) with a Ki of 86 μM. It is an analog of a substrate peptide corresponding to a phosphorylation site of histone H2B, and inhibits phosphorylation of intact histones by PKA. Synonyms: H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH.TFA; L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid trifluoroacetic acid; cGMP Dependent Kinase Inhibitor Peptide TFA. Grade: ≥95%. Molecular formula: C40H75F3N18O12. Mole weight: 1057.13. | |
| PKG Substrate | PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG). Synonyms: Arg-Lys-Arg-Ser-Arg-Ala-Glu; L-arginyl-L-lysyl-L-arginyl-L-seryl-L-arginyl-L-alanyl-L-glutamic acid; N5-(Diaminomethylidene)-L-ornithyl-L-lysyl-N5-(diaminomethylidene)-L-ornithyl-L-seryl-N5-(diaminomethylidene)-L-ornithyl-L-alanyl-L-glutamic acid; (S)-2-((6S,9S,12S,15S,18S,21S)-1,6-diamino-9-(4-aminobutyl)-12,18-bis(3-guanidinopropyl)-15-(hydroxymethyl)-1-imino-21-methyl-7,10,13,16,19-pentaoxo-2,8,11,14,17,20-hexaazadocosanamido)pentanedioic acid. Grade: ≥95%. CAS No. 81187-14-6. Molecular formula: C35H67N17O11. Mole weight: 902.01. | |
| PKG Substrate | PKG Substrate is a selective substrate for cGMP-dependent protein kinase ( PKG ). Uses: Scientific research. Group: Peptides. CAS No. 81187-14-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1561. | |
| PKG Substrate acetate | PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG). Synonyms: H-Arg-Lys-Arg-Ser-Arg-Ala-Glu-OH.CH3CO2H; L-arginyl-L-lysyl-L-arginyl-L-seryl-L-arginyl-L-alanyl-L-glutamic acid acetic acid. Grade: ≥95%. Molecular formula: C37H71N17O13. Mole weight: 962.08. | |
| Protein Kinase G Iβ human, Recombinant | Protein Kinase G Iβ induces apoptosis in certain cell lines such as human breast cancer cell lines MCF-7 and MDA-MB-468. It inhibits cell proliferation and induces apoptosis in colon cancer cell lines. > 95% (sds-page), recombinant, expressed in baculovirus infected sf9 cells, buffered aqueous glycerol solution. Applications: Protein kinase g is a serine/threonine-specific protein kinase that is activated by cgmp. protein kinase g iβ is used to induce apoptosis and inhibit cell proliferation. Group: Enzymes. Synonyms: Protein Kinase G Iβ; PRKG1B; PRKGR1B; PKG1B; cGMP-dependent protein kinase 1; cGKI-BETA. Purity: >95% (SDS-PAGE). PKG. Mole weight: mol wt 76 kDa (monomer). Activity: > 1.5 units/mg protein (20-fold stimulation by cGMP (5 μM)). Stability: -20°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells. Species: Human. Protein Kinase G Iβ; PRKG1B; PRKGR1B; PKG1B; cGMP-dependent protein kinase 1; cGKI-BETA. Cat No: NATE-0580. | |
| Protein Kinase G II from rat, Recombinant | Protein Kinase G II (cGK-II) is a membrane-associated cGMP-dependent protein kinase found in rat intestine. This product is a recombinant rat isoform isolated from baculovirus-infected Sf 9 cells. >90% (sds-page), recombinant, expressed in baculovirus infected sf9 cells, solution. Group: Enzymes. Synonyms: cGK-II; 3':5'-Cyclic GMP dependent Protein Kinase; cGMP-dependent Protein Kinase II; Protein Kinase G II; PRKG2; protein kinase, cGMP-dependent, type II; cGMP-dependent protein kinase 2; PKG2. Purity: >90% (SDS-PAGE). PKG. Activity: ~0.7 U/mg. Form: solution. Source: baculovirus infected Sf9 cells. Species: Rat. cGK-II; 3':5'-Cyclic GMP dependent Protein Kinase; cGMP-dependent Protein Kinase II; Protein Kinase G II; PRKG2; protein kinase, cGMP-dependent, type II; cGMP-dependent protein kinase 2; PKG2. Cat No: NATE-0581. | |
| 2-Acetylamino-4-methylpyridine | 2-Acetylamino-4-methylpyridine is a chemical reagent used in the synthesis of potent inhibitors of Eimeria tenalla cGMP-dependant protein kinase as antiparasitic agents. Also used in the 1-pot synthesis of difluoromethyl-2-pyridone derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 5327-32-2. Pack Sizes: 5g, 25g. Molecular Formula: C8H10N2O, Molecular Weight: 150.18. US Biological Life Sciences. | Worldwide |
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