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| Product | Description | |
|---|---|---|
| Chaetocin | Chaetocin. Group: Biochemicals. Grades: Purified. CAS No. 28097-03-2. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Chaetocin | Chaetocin is a specific inhibitor of the histone methyltransferase ( HMT ) SU(VAR)3-9 with an IC 50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase ( TrxR ) with an IC 50 of 4 μM. Uses: Scientific research. Group: Natural products. CAS No. 28097-03-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2019. |  |
| Chaetocin | It is produced by the strain of Chaetomium minutum. It has the activity of anti-gram-positive bacteria and negative bacteria. Synonyms: Caetocin; Chetocin; 3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole, bimol. deriv.; (+)-Chaetocin; (+)-Chaetocin A; Chaetocin A; [3S-[3α, 5aβ, 10bβ(3'R*, 5'aS*, 10'bS*, 11'aR*), 11aα]]-2, 2', 3, 3', 5a, 5'a, 6, 6'-Octahydro-3, 3'-bis(hydroxymethyl)-2, 2'-dimethyl-[10b, 10'b(11H, 11'H)-Bi-3, 11a-epidithio-11aH-pyrazino[1', 2':1, 5]pyrrolo[2, 3-b]indole]-1, 1', 4, 4'-tetrone; NSC-745363. Grades: >99% by HPLC. CAS No. 28097-03-2. Molecular formula: C30H28N6O6S4. Mole weight: 696.84. |  |
| Chaetocin (Chetocin) | Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumor agent. Chaetocin is a specific inhibitor for the lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress. Group: Biochemicals. Alternative Names: Chetocin. Grades: Highly Purified. CAS No. 28097-03-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Chaetocin, Lys Methyltransferase Inhibitor | Lys methyltransferase inhibitor. Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable. Group: Biochemicals. Grades: Highly Purified. CAS No. 28097-03-2. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| Leptosin I | It is produced by the strain of I Leptosphaeria sp. OUPS-4. In order to understand its cytotoxic effects, someone tested Leukemia lymphocyte P388 in culture with an ED50 of 1.13 μg/mL. Synonyms: Chaetocin, 2,5:2',5'-dide(epidithio)-19'-deoxy-2',5'-(epitetrathio)-5,6'-epoxy-6-hydroxy-19',19'-dimethyl-, (5alpha,6S,6'S,15alpha)-; (+)-Leptosin I; 22bH-18, 22a-(Iminomethano)-10b, 23a-methano-10bH, 23aH-indolo[2'', 3'':2', 3'][1, 2, 3, 4, 6]tetrathiazocino[6'', 5'':1', 5']pyrrolo[3', 4':6, 7]pyrazino[2''', 1''':2, 3][1, 3]oxazepino[4, 5-b]indole-1, 4, 17, 25(18H)-tetrone, 2, 3, 5a, 6, 15, 15a-hexahydro-24-hydroxy-3-(hydroxymethyl)-2, 26-dimethyl-18-(1-methylethyl)-, (3a, 5ab, 10ba, 10cS*, 15ab, 18b, 22ab, 22ba, 23aa, 24S*)-(+)-; Leptosine I. CAS No. 160472-96-8. Molecular formula: C32H32N6O7S4. Mole weight: 740.89. | |
| Leptosin J | It is produced by the strain of J Leptosphaeria sp. OUPS-4. In order to understand its cytotoxic effects, someone tested Leukemia lymphocyte P388 in culture with an ED50 of 1.25 μg/mL. Synonyms: Chaetocin, 2,5:2',5'-dide(epidithio)-19'-deoxy-2',5'-(epitetrathio)-5,6'-epoxy-6-hydroxy-19',19'-dimethyl-, (2alpha,5alpha,6S,6'S,15alpha)-; 22bH-18, 22a-(Iminomethano)-10b, 23a-methano-10bH, 23aH-indolo[2'', 3'':2', 3'][1, 2, 3, 4, 6]tetrathiazocino[6'', 5'':1', 5']pyrrolo[3', 4':6, 7]pyrazino[2''', 1''':2, 3][1, 3]oxazepino[4, 5-b]indole-1, 4, 17, 25(18H)-tetrone, 2, 3, 5a, 6, 15, 15a-hexahydro-24-hydroxy-3-(hydroxymethyl)-2, 26-dimethyl-18-(1-methylethyl)-, (3a, 5aa, 10bb, 10cR*, 15aa, 18a, 22aa, 22bb, 23ab, 24R*)-(+)-; Leptosine J. CAS No. 160550-15-2. Molecular formula: C32H32N6O7S4. Mole weight: 740.89. | |
| Melinacidin IV | It is produced by the strain of Verticillium tenerum. It is similar to Chaetocin and has anti-gram-positive bacterial and HeLa cell activity. Synonyms: 11,11'-Dihydroxychaetocin; (6S,6'S)-6,6'-Dihydroxychaetocin; Chetocin, 11,11'-dihydroxy-; Chaetocin, 6,6'-dihydroxy-, (6S,6'S)-; 11α,11'α-Dihydroxychactocin. CAS No. 37934-52-4. Molecular formula: C30H28N6O8S4. Mole weight: 728.84. | |
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