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It is produced by the strain of Streptomyces chartreusis. It has the activity of anti-gram-positive bacteria and mycobacterium. Chartreusin is an antitumour antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA; inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals; a potent inhibitor of topoisomerase II. Synonyms: Lambdamycin; Antibiotic X-465A; NSC 5159; (1R,2R,3aS,8aR)-1-[(Z)-5-hydroxy-3-(hydroxymethyl)pent-3-enyl]-1-(hydroxymethyl)-2,5-dimethyl-2,3,4,7,8,8a-hexahydroazulene-3a-carbaldehyde; 10-[[6-Deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione. Grades: >99% by HPLC. CAS No. 6377-18-0. Molecular formula: C32H32O14. Mole weight: 640.59.
Chartreusin (Lambdamycin)
Antibiotic. Antitumor compound. Topoisomerase II inhibitor. Induces single-strand scission in DNA in the presence of reducing agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 6377-18-0. Pack Sizes: 5mg. US Biological Life Sciences.
Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also potent inhibitor of topoisomerase II. Group: Biochemicals. Alternative Names: Lambdamycin, NSC 5159, Antibiotic 747, Antibiotic 1293, Antibiotic X465A, Antibiotic G 261A. Grades: Highly Purified. CAS No. 6377-18-0. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
3''-Demethylchartreusin
3''-Demethylchartreusin is a chartreusin antibiotic produced by Streptomyces chartreusis IF 1275. It has anti-Gram-positive bacteria activity, and has the effect of inhibiting tumor cells similar to that of Diabeticin. Synonyms: Demethylchartreusin. CAS No. 128229-64-1. Molecular formula: C31H30O14. Mole weight: 626.56.
Elsamicin B
Elsamicin B is produced by the strain of Actinomycetes J904-21. It is an antitumor antibiotic in the Chartreusin group. Aminoglycogen-deficient Elsamicin B shows only minimal antitumor activity. Synonyms: 10-[(3-C-Methyl-6-deoxy-β-D-galactopyranosyl)oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione; Benzo(h)(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,12-dione, 10-((6-deoxy-3-C-methyl-beta-D-galactopyranosyl)oxy)-6-hydroxy-1-methyl-; 6-Hydroxy-1-methyl-5,12-dioxo-5,12-dihydrobenzo[g][2]benzopyrano[5,4,3-cde][2]benzopyran-10-yl 6-deoxy-3-C-methylhexopyranoside. CAS No. 97068-31-0. Molecular formula: C26H22O10. Mole weight: 494.45.
Elsamitrucin
Elsamitrucin is produced by the strain of Actinomycetes J904-21. It has strong anti-tumor activity of mouse tumor cells such as leukemia P388, L1210 and melanoma B16, and its anti-tumor activity is 10-30 times stronger than Chartreusin. Uses: Antibiotics, antineoplastic. Synonyms: Elsamicin A. Grades: >95%. CAS No. 97068-30-9. Molecular formula: C33H35NO13. Mole weight: 653.63.
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