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Charybdotoxin is a Ca2+-activated K+ channel blocker used as an ADC Cytotoxin. Synonyms: CTX Toxin; Quinquestriatus Toxin. Grades: 95%. CAS No. 95751-30-7. Molecular formula: C176H277N57O55S7. Mole weight: 4295.88.
Charybdotoxin, recombinant from Leiurus quinquestriatus hebraeus
recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Charybdotoxin trifluoroacetate salt
Charybdotoxin is a specific inhibitor of the big conductance Ca2+-activated K+ channel which is originally isolated from the scorpion L. quinquestriatus. It blocks large-conductance Ca2+-activated K+ channels (BKCas) in GH3 rat pituitary tumor cells and primary bovine aortic smooth muscle cells (Kds = 2.1 and ~2.1 nM, respectively). Synonyms: ChTX. Grades: ≥95%. Molecular formula: C176H277N57O55S7·xCF3COOH. Mole weight: 4295.90.
Anti-Potassium Channel Kv1.3 (Charybdotoxin-Sensitive Voltage-Dependent Potassium Channel, HLK3) antibody produced in rabbit
IgG fraction of antiserum, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Kv1.3 Control Antigen (Kcna3, Charybdotoxin- sensitive Voltage-dependent Potassium Channel, HLK3)
Kv1.3 Control Antigen (Kcna3, Charybdotoxin- sensitive Voltage-dependent Potassium Channel, HLK3). Group: Molecular Biology. Grades: Purified. Pack Sizes: 120ug. US Biological Life Sciences.
Worldwide
Iberiotoxin
Iberiotoxin, a toxin extracted from the venom of the scorpion Buthus tamulus, is a selective blocker of high-conductance Ca2+-activated K+ channel. Synonyms: Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bridge: Cys7-Cys28, Cys13-Cys33, Cys17-Cys35); 5-Oxo-L-prolyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-valyl-L-α-aspartyl-L-cysteinyl-L-seryl-L-valyl-L-seryl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-tryptophyl-L-seryl-L-valyl-L-cysteinyl-L-lysyl-L-α-aspartyl-L-leucyl-L-phenylalanylglycyl-L-valyl-L-α-aspartyl-L-arginylglycyl-L-lysyl-L-cysteinyl-L-methionylglycyl-L-lysyl-L-lysyl-L-cysteinyl-L-arginyl-L-cysteinyl-L-tyrosyl-L-glutamine cyclic (7?28),(13?33),(17?35)-tris(disulfide); 4-L-aspartic acid-6-L-aspartic acid-8-L-serine-9-L-valine-18-L-lysine-19-L-aspartic acid-21-L-phenylalanine-22-glycine-23-L-valine-24-L-aspartic acid-30-glycine-37-L-glutamine-charybdotoxin. Grades: ≥96% by HPLC. CAS No. 129203-60-7. Molecular formula: C179H274N50O55S7. Mole weight: 4230.85.
Margatoxin
Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 μM concentration. Uses: Potassium channel blockers. Synonyms: MgTX. Grades: >98%. CAS No. 145808-47-5. Molecular formula: C178H286N52O50S7. Mole weight: 4178.96.
Paspalinine
Paspalinine is a tremorgenic mycotoxin extracted from the fermentation broth of Aspergillus flavus OUCMDZ-2205. It can inhibit the combination of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. It displays tremorgenic action due in part to their inhibition of GABAA receptor function. It shows insecticidal properties. Synonyms: 4H-3,15a-Epoxy-1-benzoxepino(6',7':6,7)indeno(1,2-b)indol-4-one, 2,3,5b,6,7,7a,8,13,13b,13c,14,15-dodecahydro-5b-hydroxy-2,2,13b,13c-tetramethyl-, (3R-(3alpha, 5balpha, 7abeta, 13balpha, 13cbeta, 15aalpha))-; 4H-3,15a-Epoxy-1-benzoxepino[6',7':6,7]indeno[1,2-b]indol-4-one, 2,3,5b,6,7,7a,8,13,13b,13c,14,15-dodecahydro-5b-hydroxy-2,2,13b,13c-tetramethyl-, (3R,5bS,7aS,13bS,13cR,15aS)-. Grades: ≥98%. CAS No. 63722-91-8. Molecular formula: C27H31NO4. Mole weight: 433.54.
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