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Chlorambucil (marketed as Leukeran by GlaxoSmithKline) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. It is a nitrogen mustard alkylating agent and can be given orally. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. Synonyms: gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid. Grades: >98%. CAS No. 305-03-3. Molecular formula: C14H19Cl2NO2. Mole weight: 304.21.
meta-Chlorambucil is an impurity of Chlorambucil; an alkylating agent that is used as a chemotherapy drug in the treatment of chronic lymphocytic leukemia. Synonyms: 3-[Bis(2-chloroethyl)amino]benzenebutanoic Acid; Chlorambucil Impurity. Grades: > 95%. CAS No. 134862-11-6. Molecular formula: C14H19Cl2NO2. Mole weight: 304.22.
Chlorambucil Impurity A
N-(2-Hydroxyethyl) Chlorambucil is a degradation product of Chlorambucil; an alkylating agent used as a chemotherapy drug in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Hodgkin's lymphoma (NHL) and Hodgkin's disease. Synonyms: 4-[(2-Chloroethyl)(2-hydroxyethyl)amino]benzenebutanoic Acid; 4-[p-[(2-Chloroethyl)(2-hydroxyethyl)amino]phenylbutyric Acid; 4-[4-N-(2-Chloroethyl)-N-(2-hydroxyethyl)aminophenyl]butyric Acid; NSC 119101; Chlorambucil Impurity. Grades: > 95%. CAS No. 27171-89-7. Molecular formula: C14H20ClNO3. Mole weight: 285.77.
Chlorambucil Impurity B
N-Des-(2-chloroethyl) Chlorambucil is the half-mustard analog of Chlorambucil and exhibits mutagenic activity. Synonyms: 4-[(2-Chloroethyl)amino]benzenebutanoic Acid; Chlorambucil Impurity. Grades: > 95%. CAS No. 116505-53-4. Molecular formula: C12H16ClNO2. Mole weight: 241.72.
3,4-Dehydro Chlorambucil
(E)-4-[4-[Bis(2-chloroethyl)amino]phenyl]-3-butenoic Acid is a metabolite of Chlorambucil, a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. Synonyms: 3,4-Dehydro Chlorambucil. Grades: > 95%. CAS No. 73027-06-2. Molecular formula: C14H17Cl2NO2. Mole weight: 302.2.
4-[Bis (2-chloroethyl) aminophenyl]butyric acid
4-[Bis (2-chloroethyl) aminophenyl]butyric acid. Group: Biochemicals. Alternative Names: Chlorambucil. Grades: Highly Purified. CAS No. 305-03-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C14H19Cl2NO2. US Biological Life Sciences.
(E) -4-[4-[Bis (2-chloroethyl) amino]phenyl]-3-butenoic Acid. Group: Biochemicals. Alternative Names: 3,4-Dehydro Chlorambucil. Grades: Highly Purified. CAS No. 73027-06-2. Pack Sizes: 5mg. Molecular Formula: C14H17Cl2NO2, Molecular Weight: 302.2. US Biological Life Sciences.
Worldwide
Obinutuzumab
Obinutuzumab is a humanized monoclonal antibody that inhibits CD20 for cancer therapy. In combination with chlorambucil, it was approved as a first-line treatment for chronic lymphocytic leukemia. It also can be used to treat follicular lymphoma. Uses: The treatment of chronic lymphocytic leukemia. Synonyms: GA101; GA 101; GA-101. CAS No. 949142-50-2. Molecular formula: C6512H10060N1712O2020S44. Mole weight: 146100.
Ofatumumab
Ofatumumab is a CD20-directed cytolytic monoclonal antibody with an inhibitory effect on early-stage B lymphocyte. It was approved by FDA for its use to treat patients with chronic lymphocytic leukemia (CLL) as an extended treatment or in combination with chlorambucil. It also has the thearapeutic effect on some other diseases such as follicular lymphoma. Uses: The treatment of chronic lymphocytic leukemia (cll). CAS No. 679818-59-8. Molecular formula: C6480H10022N1742O2020S44. Mole weight: 146100.
Phenylacetic acid mustard
Phenylacetic Mustard is a nitrogen mustard analog and the active metabolite of Chlorambucil. It is used as a chemotherapeutic agent and aside from having clastogenic activity, it can also induce chromosome delay. Synonyms: 4-[Bis(2-chloroethyl)amino]benzeneacetic Acid; [p-[Bis(2-chloroethyl)amino]phenyl]acetic Acid; 2-[p-[Bis(2-chloroethyl)amino]phenyl]acetic Acid; 4-[N,N-Bis(2-chloroethyl)amino]phenylacetic Acid; Chlorophenacyle; Chlorphenacyl; N,N-Bis(2-chloroethyl)-p-ami. Grades: > 95%. CAS No. 10477-72-2. Molecular formula: C12H15Cl2NO2. Mole weight: 276.16.
Prednimustine
Prednimustine is a drug used in chemotherapy. It is the ester formed from two other drugs, prednisolone and chlorambucil. Prednimustine probably kills rapidly growing cells by modifying cell's DNA with a chemical structure called an alkyl group. Uses: Antineoplastic agents, alkylating. Synonyms: LEO 1031; LEO1031; LEO-1031; Stereocyt; NSC-134087; (11beta)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate; NSC-171345; BRN 2826967. Grades: >98%. CAS No. 29069-24-7. Molecular formula: C35H45Cl2NO6. Mole weight: 646.65.
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