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| Product | Description | |
|---|---|---|
| choline kinase | Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. Group: Enzymes. Synonyms: choline kinase (phosphorylating); choline phosphokinase; choline-ethanolamine kinase. Enzyme Commission Number: EC 2.7.1.32. CAS No. 9026-67-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3063; choline kinase; EC 2.7.1.32; 9026-67-9; choline kinase (phosphorylating); choline phosphokinase; choline-ethanolamine kinase. Cat No: EXWM-3063. |  |
| Choline Kinase-a Inhibitor, CK37 (CK37, N-(3,5-dimethyl-dimethylphenyl)-2-[[5-(4-ethylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide) | A cell-permeable, non-Hemicholinium-3 derivative and choline-competitive choline kinase-a inhibitor. It is demonstrated to inhibit endogenous choline kinase activity, dose-dependently, between 1-10uM, and dose-dependently decrease phosphocholine concentrations, as well as levels of downstream choline metabolites, including phosphatidylcholine and phosphatidic acid in HeLa cells. At 10uM, it is also shown to attenuate MAPK and PI3K/AKT signaling, and disrupt the actin cytoskeleton and membrane ruffling, consistent with siRNA choline kinase-a transfection. This compound exhibits dose-dependent suppression of cell growth in six tumor cell lines (IC50=5-10uM), in vitro. Furthermore, it is shown to suppress tumor growth in a mouse model by 48% at 0.08mg/g daily dose for 8 days without obvious toxicity, in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1001478-90-5. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Choline Kinase (Crude Enzyme) | Choline kinase (also known as CK,ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine. Thus, the two substrates of this enzyme are ATP and choline, whereas its two products are adenosine diphosphate (ADP) and O-phosphocholine. Choline kinase requires magnesium ions (+2) as a cofactor for this reaction. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol grou... CHKA and CHKB and are only active in their homodimeric, heterodimeric and oligomeric forms. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Biotechnology; diagnostics; drug development; medicine. Group: Enzymes. Synonyms: Choline Kinase (phosphorylating); choline phosphokinase; choline-ethanolamine kinase. Enzyme Commission Number: EC 2.7.1.32. CAS No. 9026-67-9. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. Choline Kinase (phosphorylating); choline phosphokinase; choline-ethanolamine kinase. Pack: 100ml. Cat No: NATE-1825. | |
| 6-Hexadecanoylamino-4-methylumbelliferyl phosphorylcholine | 6-Hexadecanoylamino-4-methylumbelliferyl phosphorylcholine is a biochemical compound used in the biomedical industry for research purposes. It is commonly used as a substrate to detect choline kinases and choline phosphotransferases aiding in the study of diseases like cancer and Alzheimer's. With its fluorescent properties, this compound enables easy detection and analysis of enzymatic activities related to these diseases. Synonyms: [6-(Hexadecanoylamino)-4-methyl-2-oxochromen-7-yl] 2-(trimethylazaniumyl)ethyl phosphate; 6-(hexadecanoylamino)-4-methyl-2-oxo-2H-chromen-7-yl 2-(trimethylammonio)ethyl phosphate; 4-Methyl-2-oxo-6-palmitamido-2H-chromen-7-yl (2-(trimethylammonio)ethyl) phosphate; {[4-METHYL-2-OXO-6- (PALMITOYLAMINO) -2H-CHROMEN-7-YL]OXY} (OXO) [2- (TRIMETHYLAMMONIO) ETHOXY]PHOSPHORANOLATE; 2-[[Hydroxy[[4-methyl-2-oxo-6-[(1-oxohexadecyl)amino]-2H-1-benzopyran-7-yl]oxy]phosphinyl]oxy]-N,N,N-trimethylethanaminium inner salt. CAS No. 904315-61-3. Molecular formula: C31H51N2O7P. Mole weight: 594.72. |  |
| Amifampridine | Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. It is used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. Uses: Neuromuscular agents. Synonyms: pyridine-3,4-diamine. Grades: > 98 %. CAS No. 54-96-6. Molecular formula: C5H7N3. Mole weight: 109.13. | |
| Amifampridine Phosphate | Amifampridine is a drug, predominantly used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. Uses: Predominantly in the treatment of a number of rare muscle diseases. Synonyms: phosphoric acid;pyridine-3,4-diamine. Grades: ≥98%. CAS No. 446254-47-3. Molecular formula: C5H10N3O4P. Mole weight: 207.12. | |
| Bisindolylmaleimide II | Bisindolylmaleimide II is a potent and ATP-competitive inhibitor of protein kinase C (PKC) (IC50 = 0.01 μM). It also displays an antagonistic effect on nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells) and an inhibitory effect on PDK1 (IC50 = 14 μM). Synonyms: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione. Grades: ≥97% by HPLC. CAS No. 137592-45-1. Molecular formula: C27H26N4O2. Mole weight: 438.52. | |
| MN58b bromide | MN58b bromide, or MN58b, is a selective choline kinase α (CHKα) inhibitor. MN58b is a novel anticancer drug that inhibits choline kinase, resulting in inhibition of phosphocholine synthesis. Inhibition of choline kinase by MN58b resulted in altered phospholipid metabolism both in cultured tumor cells and in vivo. Group: Inhibitors. Alternative Names: MN58b bromide; MN58b; MN 58b; MN 58b. CAS No. 203192-01-2. Molecular formula: C32H40Br2N4. Mole weight: 640.51. Appearance: Solid powder. Purity: >97%. IUPACName: 1, 1'- ( (butane-1, 4-diylbis (4, 1-phenylene))bis (methylene))bis (4- (dimethylamino)pyridin-1-ium) bromide. Canonical SMILES: CN (C)C1=CC=[N+] (C=C1)CC2=CC=C (CCCCC3=CC=C (C[N+]4=CC=C (N (C)C)C=C4)C=C3)C=C2. [Br-]. [Br-]. Catalog: ACM203192012. |  |
| Native Streptomyces sp. Phospholipase D | Phospholipase D (PLD) is glycerophospholipid-specific. It is markedly less active on sphingomyelins and lysophospholipids. Phospholipase D hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Applications: Phospholipase d (pld) has been used to hydrolyze the phosphate bonds of phospholipids and sphingomyelin to yield the corresponding phosphatidic acid. it has also been used to study metabolic labeling and direct imaging of choline phospholipids in vivo by measuring propargyl-cho incorporation. furthermore, pld has been used in purification and kinetic studies. the enzyme has been used in the translocation of sphingosine kinase 1 (sk1) to membrane fractions under in vitro conditions. it has also been used to produce phosphatidic acid (pa) from phosphatidylcholine (pc) in hl60 permeabilized cells. Group: Enzymes. Synonyms: phospholipase D; lipophosphodiesterase II; lecithinase D;. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 150 units/mg solid. Storage: -20°C. Form: Type VII, lyophilized powder. Source: Streptomyces sp. phospholipase D; lipophosphodiesterase II; lecithinase D; choline phosphatase; phosphatidylcholine phosphatidohydrolase; EC 3.1.4.4; 9001-87-0; PLD. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0597. | |
| RSM-932A | RSM-932A is a novel anticancer drug. Its target is the human choline kinase alpha. Choline kinase alpha is an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A can reduce parasitemia and induce the accumulation of trophozoites and schizonts, blocking intraerythrocytic development and interfering with parasite egress or invasion. Uses: Anticancer. Synonyms: RSM-932A; RSM 932A; RSM932A; TCD 717; TCD717; TCD-717.1,1'-([1,1'-biphenyl]-4,4'-diylbis(methylene))bis(4-((4-chlorophenyl)(methyl)amino)quinolin-1-ium) bromide. Grades: 98%. CAS No. 850807-63-5. Molecular formula: C46H38Br2Cl2N4. Mole weight: 877.55. | |
| Y27632 | Y-27632 is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 increases the release of neurotransmitters from cholinergic nerves. Uses: Reprogramming, self-renewal. Synonyms: Y27632; Y 27632; Y-27632. Grades: 98% by HPLC. CAS No. 146986-50-7. Molecular formula: C14H21N3O. Mole weight: 247.34. | |
| 3-O-tert-Butyl di methyl silyl -D-Erythro-sphingosyl phosphoryl choline | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| D-Erythro-Sphingosyl phosphoryl choline | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
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