Choline Kinase Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Choline Kinase-a Inhibitor, CK37 (CK37, N-(3,5-dimethyl-dimethylphenyl)-2-[[5-(4-ethylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide) Quick inquiry Where to buy Suppliers range | A cell-permeable, non-Hemicholinium-3 derivative and choline-competitive choline kinase-a inhibitor. It is demonstrated to inhibit endogenous choline kinase activity, dose-dependently, between 1-10uM, and dose-dependently decrease phosphocholine concentrations, as well as levels of downstream choline metabolites, including phosphatidylcholine and phosphatidic acid in HeLa cells. At 10uM, it is also shown to attenuate MAPK and PI3K/AKT signaling, and disrupt the actin cytoskeleton and membrane ruffling, consistent with siRNA choline kinase-a transfection. This compound exhibits dose-dependent suppression of cell growth in six tumor cell lines (IC50=5-10uM), in vitro. Furthermore, it is shown to suppress tumor growth in a mouse model by 48% at 0.08mg/g daily dose for 8 days without obvious toxicity, in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1001478-90-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
3-O-tert-Butyl di methyl silyl -D-Erythro-sphingosyl phosphoryl choline Quick inquiry Where to buy Suppliers range | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
6-Hexadecanoylamino-4-methylumbelliferyl phosphorylcholine Quick inquiry Where to buy Suppliers range | 6-Hexadecanoylamino-4-methylumbelliferyl phosphorylcholine is a biochemical compound used in the biomedical industry for research purposes. It is commonly used as a substrate to detect choline kinases and choline phosphotransferases aiding in the study of diseases like cancer and Alzheimer's. With its fluorescent properties, this compound enables easy detection and analysis of enzymatic activities related to these diseases. Synonyms: [6-(Hexadecanoylamino)-4-methyl-2-oxochromen-7-yl] 2-(trimethylazaniumyl)ethyl phosphate; 6-(hexadecanoylamino)-4-methyl-2-oxo-2H-chromen-7-yl 2-(trimethylammonio)ethyl phosphate; 4-Methyl-2-oxo-6-palmitamido-2H-chromen-7-yl (2-(trimethylammonio)ethyl) phosphate; {[4-METHYL-2-OXO-6- (PALMITOYLAMINO) -2H-CHROMEN-7-YL]OXY} (OXO) [2- (TRIMETHYLAMMONIO) ETHOXY]PHOSPHORANOLATE; 2-[[Hydroxy[[4-methyl-2-oxo-6-[(1-oxohexadecyl)amino]-2H-1-benzopyran-7-yl]oxy]phosphinyl]oxy]-N,N,N-trimethylethanaminium inner salt. CAS No. 904315-61-3. Molecular formula: C31H51N2O7P. Mole weight: 594.72. | |
Amifampridine Quick inquiry Where to buy Suppliers range | Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. It is used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. Uses: Neuromuscular agents. Synonyms: pyridine-3,4-diamine. Grades: > 98 %. CAS No. 54-96-6. Molecular formula: C5H7N3. Mole weight: 109.13. | |
Amifampridine Phosphate Quick inquiry Where to buy Suppliers range | Amifampridine is a drug, predominantly used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. Uses: Predominantly in the treatment of a number of rare muscle diseases. Synonyms: phosphoric acid;pyridine-3,4-diamine. Grades: ≥98%. CAS No. 446254-47-3. Molecular formula: C5H10N3O4P. Mole weight: 207.12. | |
Bisindolylmaleimide II Quick inquiry Where to buy Suppliers range | Bisindolylmaleimide II is a potent and ATP-competitive inhibitor of protein kinase C (PKC) (IC50 = 0.01 μM). It also displays an antagonistic effect on nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells) and an inhibitory effect on PDK1 (IC50 = 14 μM). Synonyms: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione. Grades: ≥97% by HPLC. CAS No. 137592-45-1. Molecular formula: C27H26N4O2. Mole weight: 438.52. | |
D-Erythro-Sphingosyl phosphoryl choline Quick inquiry Where to buy Suppliers range | Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
RSM-932A Quick inquiry Where to buy Suppliers range | RSM-932A is a novel anticancer drug. Its target is the human choline kinase alpha. Choline kinase alpha is an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A can reduce parasitemia and induce the accumulation of trophozoites and schizonts, blocking intraerythrocytic development and interfering with parasite egress or invasion. Uses: Anticancer. Synonyms: RSM-932A; RSM 932A; RSM932A; TCD 717; TCD717; TCD-717.1,1'-([1,1'-biphenyl]-4,4'-diylbis(methylene))bis(4-((4-chlorophenyl)(methyl)amino)quinolin-1-ium) bromide. Grades: 98%. CAS No. 850807-63-5. Molecular formula: C46H38Br2Cl2N4. Mole weight: 877.55. | |
Y27632 Quick inquiry Where to buy Suppliers range | Y-27632 is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 increases the release of neurotransmitters from cholinergic nerves. Uses: Reprogramming, self-renewal. Synonyms: Y27632; Y 27632; Y-27632. Grades: 98% by HPLC. CAS No. 146986-50-7. Molecular formula: C14H21N3O. Mole weight: 247.34. |