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Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis. Synonyms: EPC2407; EPC 2407; EPC-2407; (R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile. CAS No. 1000852-17-4. Molecular formula: C18H17BrN4O3. Mole weight: 417.263.
UCPH 101
UCPH 101 is a selective non-substrate inhibitor of EAAT1 (IC50 = 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3, respectively). UCPH 101 selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 μM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 μM. Synonyms: UCPH-101, UCPH 101, UCPH101; 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile. Grades: ≥98% by HPLC. CAS No. 1118460-77-7. Molecular formula: C27H22N2O3. Mole weight: 422.48.
Solvent Red 197
Alfa Chemistry offers high-purity Solvent Red 197 products for various research purposes. Please contact us by email if you do not find the specification you are looking for on this page. Uses: Such coumarin dyes are useful for laser dyes emitting blue-green light. Group: Electronic materials coumarin dyes. Alternative Names: 3-(Diethylamino)-7-imino-7H-benzo[4,5]imidazo[1,2-a]chromeno[3,2-c]pyridine-6-carbonitrile. CAS No. 52372-39-1. Pack Sizes: 1G-Glass Bottle with Plastic Insert (View image). Product ID: 17-(diethylamino)-11-imino-14-oxa-3, 10-diazapentacyclo[11.8.0.02, 10.04, 9.015, 20]henicosa-1(21), 2, 4, 6, 8, 12, 15(20), 16, 18-nonaene-12-carbonitrile. Molecular formula: 381.44. Mole weight: C23H19N5O. CCN (CC)C1=CC2=C (C=C1)C=C3C (=C (C (=N)N4C3=NC5=CC=CC=C54)C#N)O2. InChI=1S/C23H19N5O/c1-3-27 (4-2)15-10-9-14-11-16-21 (29-20 (14)12-15)17 (13-24)22 (25)28-19-8-6-5-7-18 (19)26-23 (16)28/h5-12, 25H, 3-4H2, 1-2H3. FXFIDVQMNRVEGQ-UHFFFAOYSA-N. >98.0%(HPLC)(N).
Solvent Red 197
Alfa Chemistry offers high-purity Solvent Red 197 products for various research purposes. Please contact us by email if you do not find the specification you are looking for on this page. Uses: Such coumarin dyes are useful for laser dyes emitting blue-green light. Group: Solvent dyes. Alternative Names: 3-(Diethylamino)-7-imino-7H-benzo[4,5]imidazo[1,2-a]chromeno[3,2-c]pyridine-6-carbonitrile. CAS No. 52372-39-1. Molecular formula: C23H19N5O. Mole weight: 381.44. Appearance: Orange to Brown to Dark red powder to crystal. Purity: >98.0%(HPLC)(N). IUPACName: 17-(diethylamino)-11-imino-14-oxa-3, 10-diazapentacyclo[11.8.0.02, 10.04, 9.015, 20]henicosa-1(21), 2, 4, 6, 8, 12, 15(20), 16, 18-nonaene-12-carbonitrile. Canonical SMILES: CCN (CC)C1=CC2=C (C=C1)C=C3C (=C (C (=N)N4C3=NC5=CC=CC=C54)C#N)O2. Density: 1.33 ± 0.1 g/ml. ECNumber: 257-885-3. Catalog: ACM52372391-1.
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