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| Product | Description | |
|---|---|---|
| Cinnabarinic acid | Cinnabarinic acid is a kynurenine pathway metabolite of tryptophan and is produced by the oxidation of 3-Hydroxyanthranilic acid. It is a metabotropic glutamate receptor (mGlu4R-specific) agonist. It activates mGlu4 receptors in transiently transfected HEK293 cells and is selective over all other mGlu subtypes. It decreases cAMP levels in native cultured cerebellar granule cells. It may be used in studies of the functions of components of the kynurenine metabolic pathway. It leads to loss of apoptosis and mitochondrial respiration. It induces apoptosis in thymocytes by the generation of reactive oxygen species. It also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. It has neuroprotective activity. Synonyms: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 606-59-7. Molecular formula: C14H8N2O6. Mole weight: 300.22. |  |
| Cinnabarinic acid | Cinnabarinic acid is a specific orthosteric agonist of mGlu 4 by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 606-59-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W011417. |  |
| Cinnabarinic Acid | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Cinnabarinic Acid | A natural phenoxazinone derivative, Cinnabarinic acid is obtained in vitro with aid of laccase by oxidative dimerization of 3-Hydroxyanthranilic acid (a metabolite of the amino acid Trytophan). Cinnabarinic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. Group: Biochemicals. Alternative Names: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic Acid; Cinnabaric Acid. Grades: Highly Purified. CAS No. 606-59-7. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H?N?O?, Molecular Weight: 300.22. US Biological Life Sciences. |  Worldwide |
| Cinnabarinic Acid (2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid) | A partial, low-potency agonist highly selective for mGlu4 receptors (EC50 >100uM, no effect on other mGlu subtype receptors). Used in assessing the functional roles of mGlu4 receptors in a variety of research areas, such as excitotoxic cell death, apoptosis, neuroinflammation, inflammation, and neuroimmune communication. Group: Biochemicals. Grades: Highly Purified. CAS No. 606-59-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1-Hydroxy-4-methoxy-2-naphthoic acid | 1-Hydroxy-4-methoxy-2-naphthoic acid is a herbicidal compound produced by Streptosporangium cinnabarinum. Molecular formula: C12H10O4. Mole weight: 218.21. | |
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