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| Product | Description | |
|---|---|---|
| CL-316243 | CL-316243 is a potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM) with > 10000-fold selective over β1 and β2 receptors. CL 316243 possesses anti-obesity and anti-diabetic effects due to increasing brown adipose tissue thermogenesis and metabolic rate, and consequently may be useful for treating obesity as well as non-insulin-dependent diabetes mellitus in obese persons, without causing excessive side effects. Synonyms: CL-316243; CL 316243; CL316243; 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate; 138908-40-4 (CL-316243 sodium). Grades: >98%. CAS No. 183720-02-7. Molecular formula: C20H20ClNNa2O7. Mole weight: 419.794. |  |
| CL-316243 sodium | CL-316243 is a highly selective β3-adrenoceptor agonist with EC50 value of 3 nM; > 10000-fold selective over β1 and β2 receptors. CL-316243 can restore the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice and enhance insulin-stimulated glucose disposal in nonobese rats. Preclical trials for the treatment of Obesity, Overactive bladder and Type 2 diabetes mellitus were discontinued. Uses: Obesity; overactive bladder; type 2 diabetes mellitus. Synonyms: CL-316243 sodium; CL 316243 sodium; CL316243 sodium; disodium;5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate;BTA 243; HP 186; BTA243; HP186; BTA-243; HP-186. Grades: 98%. CAS No. 138908-40-4. Molecular formula: C20H18ClNNa2O7. Mole weight: 465.79. | |
| CL 316243 disodium salt | The sodium salt form of CL 316243, which has been found to be a β3-adrenoceptor agonist and could probably decrease blood insulin as well as glucose levels. Synonyms: CL 316243 disodium salt; CL316243 disodium salt; CL-316243 disodium salt; 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt. Grades: ≥98% by HPLC. CAS No. 151126-84-0. Molecular formula: C20H18ClNNa2O7. Mole weight: 465.80. | |
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