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| Product | Description | |
|---|---|---|
| Cl-amidine | Cl-amidine is an inhibitor of irreversible protein pan-peptidylarginine deiminase (PAD) with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine that is important for its catalytic activity. Synonyms: N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide. Grades: ≥95%. CAS No. 1043444-18-3. Molecular formula: C14H19ClN4O2·C2HF3O2. Mole weight: 424.8. |  |
| Cl-amidine hydrochloride | Cl-amidine hydrochloride Inhibitor. Uses: Scientific use. Product Category: T10831L. CAS No. 1373232-26-8. |  |
| Cl-amidine hydrochloride | Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 ?M, 6.2 ?M and 5.9 ?M for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1373232-26-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100574A. |  |
| Cl-Amidine hydrochloride | Cl-amidine is an inhibitor of irreversible protein pan-peptidylarginine deiminase (PAD) with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine that is important for its catalytic activity. Synonyms: N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide monohydrochloride. Grades: ≥95%. CAS No. 1373232-26-8. Molecular formula: C14H19ClN4O2·HCl. Mole weight: 347.24. | |
| CAY10729 trifluoroacetate salt | Peptidyl Arginine Deiminases (PADs) perform post-translational deiminations of proteins. PADs are calcium-dependent enzymes that catalyze the conversion of L-arginine residues to L-citrulline. CAY10729 is a tetrazole derivative of the PAD inhibitor Cl-amidine that selectively inhibits PAD1 over PAD2, PAD3, and PAD4 (kinact/KI = 162,200, 60,000, 17,500, and 25,400 M-1min-1 for PAD1-4, respectively). Synonyms: CAY 10729; CAY-10729. Grades: ≥70%. Molecular formula: C19H26ClN7O3·xCF3COOH. Mole weight: 435.91. | |
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