Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Clozapine | 25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C18H19ClN4. CAS No. 5786-21-0. Prepack ID 66826682-25mg. Molecular Weight 326.82. See USA prepack pricing. |  |
| Clozapine | Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K i s of 9.5 nM and 4 nM, respectively [1] [2] [3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor ( EC 50 =11 nM) [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HF 1854. CAS No. 5786-21-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg. Product ID: HY-14539. |  |
| Clozapine | Clozapine is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia. Uses: Antipsychotic agents; gaba antagonists; serotonin antagonists. Synonyms: HF 1854; HF1854; HF-1854; LX 100-129; LX-100-129; LX100-129. Grades: >98%. CAS No. 5786-21-0. Molecular formula: C18H19ClN4. Mole weight: 326.82. |  |
| Clozapine-5-N-Glucuronide | Clozapine 5-N-glucuronide is a metabolite of Clozapine, an antipsychotic. Synonyms: Clozapine 5-N-glucuronide; 390651-03-3; Clozapine-5-N-Glucuronide; 6-[3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]-3,4,5-trihydroxyoxane-2-carboxylic acid. Grades: > 95%. CAS No. 390651-03-3. Molecular formula: C24H27ClN4O6. Mole weight: 502.95. | |
| Clozapine-d4 | Clozapine-d 4 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: HF 1854-d4. CAS No. 204395-52-8. Pack Sizes: 1 mg. Product ID: HY-14539S2. | |
| Clozapine-d8 (8-Chloro-11-(4-methyl-1-piperazinyl-d8)-5H-dibenzo[b, e][1, 4]diazepine, HF-1854-d8, Liponex-d8) | An antipsychotic.A representative lot was 92% d8, 8% d7. Group: Biochemicals. Alternative Names: 8-Chloro-11-(4-methyl-1-piperazinyl-d8)-5H-dibenzo[b, e][1, 4]diazepine; HF-1854-d8; Liponex-d8. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Clozapine EP Impurity B | 11,11'-(Piperazine-1,4-diyl)bis(8-chloro-5H-dibenzo[b,e][1,4]-diazepine) is an impurity in commercial preparations of Clozapine. Synonyms: 11,11'-(Piperazine-1,4-diyl)bis(8-chloro-5H-dibenzo[b,e][1,4]-diazepine). Grades: > 95%. CAS No. 263366-81-0. Molecular formula: C30H24Cl2N6. Mole weight: 539.46. | |
| Clozapine EP Impurity D | [2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone is used in the synthesis of substituted dibenzodiazepines. It is also an impurity in the synthesis of Clozepine, an antipsychotic. Synonyms: [2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone; 1-[2-[(2-Amino-4-chlorophenyl)amino]benzoyl]-4-methylpiperazine. Grades: > 95%. CAS No. 65514-71-8. Molecular formula: C18H21ClN4O. Mole weight: 344.84. | |
| Clozapine hydrochloride | Clozapine (HF 1854) is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor. Clozapine is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It also binds to the 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors, as well as the histamine H1 and α1-adrenergic receptors. Synonyms: 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride; HF 1854 dihydrochloride. Grades: ≥98%. Molecular formula: C18H19ClN4·2HCl. Mole weight: 399.74. | |
| Clozapine Impurity 10 | Clozapine Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((2-aminophenyl)amino)benzoic acid. CAS No. 27696-24-8. Molecular Formula: C13H12N2O2. Mole Weight: 228.09. Catalog: APB27696248. |  |
| Clozapine Impurity 11 | Clozapine Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((4-chloro-2-(sulfoamino)phenyl)amino)benzoic acid. Molecular Formula: C13H11ClN2O5S. Mole Weight: 342.01. Catalog: APB04322. | |
| Clozapine Impurity 12 | Clozapine Impurity 12. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5H-dibenzo[b,e][1,4]diazepin-11(10H)-one. CAS No. 5814-41-5. Molecular Formula: C13H10N2O. Mole Weight: 210.08. Catalog: APB5814415. | |
| Clozapine Impurity 6 | Clozapine Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1025951-76-1. Molecular Formula: C20H21ClN4O. Mole Weight: 368.86. Catalog: APB1025951761. | |
| Clozapine Impurity 7 | Clozapine Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2-aminobenzamido)benzoic acid. CAS No. 612-34-0. Molecular Formula: C14H12N2O3. Mole Weight: 256.08. Catalog: APB612340. | |
| Clozapine Impurity 7 | Clozapine Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 60091-87-4. Molecular Formula: C13H9ClN2O4. Mole Weight: 292.68. Catalog: APB60091874. | |
| Clozapine Impurity 8 | Clozapine Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2-((4-chloro-2-nitrophenyl)amino)benzamido)benzoic acid. Molecular Formula: C20H14ClN3O5. Mole Weight: 411.80. Catalog: APB04323. | |
| Clozapine Impurity 8 | Clozapine Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 67990-66-3. Molecular Formula: C13H11ClN2O2. Mole Weight: 262.69. Catalog: APB67990663. | |
| Clozapine Impurity 9 | Clozapine Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 63687-95-6. Molecular Formula: C17H18N4O. Mole Weight: 294.36. Catalog: APB63687956. | |
| Clozapine Impurity A | 8-Chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one is a useful intermediate for the preparation of pharmaceutical actives and fine chemicals. Synonyms: 8-Chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one. Grades: > 95%. CAS No. 50892-62-1. Molecular formula: C13H9ClN2O. Mole weight: 244.68. | |
| Clozapine N-Glucuronide | Clozapine N-Glucuronide. Uses: For analytical and research use. Group: Impurity standards. CAS No. 165602-86-8. Molecular Formula: C24H27N4O6. Mole Weight: 502.95. Catalog: APB165602868. | |
| Clozapine N-oxide | Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier [1] [2] [3] [4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor ( EC 50 =11 nM) agonist [5] [6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 34233-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17366. | |
| Clozapine N-Oxide | Clozapine N-oxide is a major metabolite of clozapine, and acts as an antagonist of 5-HT receptor. Uses: Antipsychotic agents. Synonyms: 3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-11H-benzo[b][1,4]benzodiazepine. Grades: >98%. CAS No. 34233-69-7. Molecular formula: C18H19ClN4O. Mole weight: 342.827. | |
| Clozapine N-oxide dihydrochloride | Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier [1] [2] [3] [4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor ( EC 50 =11 nM) agonist [5] [6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2250025-93-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17366A. | |
| Clozapine N-oxide dihydrochloride | Clozapine N-oxide dihydrochloride is a water-soluble salt of Clozapine N-oxide. Clozapine N-oxide is a major metabolite of clozapine and an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors. It exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less conversion to clozapine in animal studies. Synonyms: 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride; CNO. Grades: ≥99% by HPLC. CAS No. 2250025-93-3. Molecular formula: C18H19ClN4O·2HCl. Mole weight: 415.74. | |
| Clozapine (Standard) | Clozapine (Standard) is the analytical standard of Clozapine. This product is intended for research and analytical applications. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K i s of 9.5 nM and 4 nM, respectively [1] [2] [3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor ( EC 50 =11 nM) [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HF 1854 (Standard). CAS No. 5786-21-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14539R. | |
| 7-Hydroxyl Clozapine | 7-Hydroxyl Clozapine. Uses: For analytical and research use. Group: Impurity standards. CAS No. 355004-92-1. Molecular Formula: C18H19ClN4O. Mole Weight: 342.83. Catalog: APB355004921. | |
| 8-Hydroxyl Clozapine | 8-Hydroxyl Clozapine. Uses: For analytical and research use. Group: Impurity standards. CAS No. 63687-94-5. Molecular Formula: C18H20N4O. Mole Weight: 308.38. Catalog: APB63687945. | |
| 9-Hydroxyl Clozapine | 9-Hydroxyl Clozapine. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1239601-19-4. Molecular Formula: C18H19ClN4O. Mole Weight: 342.83. Catalog: APB1239601194. | |
| Isoclozapine | Isoclozapine, a 2-Cl analogue of clozapine, is a 5-HT antagonist as a typical antipsychotic. Synonyms: 2-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine. Grades: 98%. CAS No. 1977-8-8. Molecular formula: C18H19ClN4. Mole weight: 326.82. | |
| N-Desmethyl 8-Chloro-5H-dibenzo[b, e][1, 4]diazepine Clozapine-d8 | N-Desmethyl 8-Chloro-5H-dibenzo[b, e][1, 4]diazepine Clozapine-d8. Group: Biochemicals. Alternative Names: 11, 11'-(1, 4-Piperazinediyl)bis[8-chloro-5H-dibenzo[b, e][1, 4]diazepine-d8. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C30H16D8Cl2N6, Molecular Weight: 547.51. US Biological Life Sciences. | Worldwide |
| N-Desmethylclozapine | N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist ( EC 50 =115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Norclozapine; Desmethylclozapine; Normethylclozapine. CAS No. 6104-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-G0021. | |
| N-Desmethyl clozapine | N-Desmethyl clozapine is a metabolite of clozapine, an atypical antipsychotic drug that acts as a 5-HT antagonist. Synonyms: Norclozapine; Desmethylclozapine; 3-chloro-6-piperazin-1-yl-11H-benzo[b][1,4]benzodiazepine. Grades: ≥98%. CAS No. 6104-71-8. Molecular formula: C17H17ClN4. Mole weight: 312.80. | |
| 1-(8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b, e][1, 4]diazepin-5-yl)ethanone | 1-(8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b, e][1, 4]diazepin-5-yl)ethanone is an impurity of Clozapine, which is an antipsychotic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1025951-76-1. Pack Sizes: 50mg, 250mg. Molecular Formula: C20H21ClN4O, Molecular Weight: 368.86. US Biological Life Sciences. | Worldwide |
| Chlorprothixene hydrochloride | Chlorprothixene hydrochloride is the hydrochloride salt form of chlorprothixene, a typical thioxanthine antipsychotic that functions by antagonizing dopamine D2 receptors. It can block a subset of GABAA receptors in rat cortex that is also blocked by clozapine. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. It has also been shown to be effective against P. falciparum growth with an EC50 value of 1.7 μM. Synonyms: cis-Chlorprothixene; NSC 169899; Minithixen hydrochloride; Truxal hydrochloride; NSC 56379; NSC 78193; (3Z)-3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride. Grades: ≥98%. CAS No. 6469-93-8. Molecular formula: C18H18ClNS·HCl. Mole weight: 352.3. | |
| Clothiapine | Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2058-52-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-117083. | |
| GMC 1-116 | GMC 1-116 is a metabolite of clozapine with weak 5-HT2 affinity and high M1 affinity (IC50 = 27 nM). Synonyms: 11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol; 8-Hydroxyclozapine; AC1L9SL1; 6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepin-3-ol. Grades: 99%. CAS No. 63687-94-5. Molecular formula: C18H20N4O. Mole weight: 308.38. | |
| GMC 1-165 | GMC 1-165 is an analogue of clozapine with 5-HT2A/2C and hM1 receptor affinities. Synonyms: 11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-2-ol; 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-8-ol. Grades: 99%. CAS No. 156632-07-4. Molecular formula: C18H20N4O. Mole weight: 308.38. | |
| GMC 61-39 | GMC 61-39 is a clozapine-like atypical antipsychotic. Uses: Atypical antipsychotic. Synonyms: [3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepin-8-yl] trifluoromethanesulfonate. Grades: 98%. CAS No. 234113-94-1. Molecular formula: C19H18ClF3N4O3S. Mole weight: 474.88. | |
| PNU 96415E | PNU 96415E, chemically unrelated to clozapine, exhibits high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki= 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). PNU-96415E has a profile of behavioral effects in rodents very similar to that of clozapine, including complete discriminative stimulus generalization. Synonyms: PNU 96415E; PNU96415E; PNU-96415E; 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 170856-41-4. Molecular formula: C21H25FN2O.2HCl. Mole weight: 413.36. | |
| Sonepiprazole | A selective D4 dopamine antagonist that exhibits low affinity at other monoamine receptors (Ki > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to Clozapine. Group: Biochemicals. Alternative Names: 4- [4- [2- [ (1S) -3, 4-Dihydro-1H-2-benzopyran-1-yl] ethyl] -1-piperazinyl] benzenesulfonamide; PNU 101387; U 101387; (S) -4- [4- [2- (3, 4-Dihydro-1H-2-benzopyran-1-yl) ethyl] -1-piperazinyl] benzenesulfonamide; PF-05191680. Grades: Highly Purified. CAS No. 170858-33-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Sonepiprazole | Sonepiprazole is a selective, brain penetrating and orally bioactive antagonist for the rat and human dopamine D4 receptor (Ki = 10 nM) with low affinity at other monoamine receptors (Ki > 2000 nM). Sonepiprazole was shown to induce c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine. Synonyms: 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 170858-33-0. Molecular formula: C21H27N3O3S. Mole weight: 401.52. | |
Our database is helping our users find suppliers everyday.
