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| Product | Description | |
|---|---|---|
| Combretastatin A4 | Combretastatin A4. Group: Biochemicals. Grades: Purified. CAS No. 117048-59-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Combretastatin A4 | Combretastatin A4 is a microtubule -targeting agent that binds β-tubulin with K d of 0.4 μM. Uses: Scientific research. Group: Natural products. Alternative Names: CRC 87-09. CAS No. 117048-59-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2146. |  |
| Combretastatin A4 phosphate disodium salt | Combretastatin A4 phosphate disodium salt. Group: Biochemicals. Alternative Names: 2-Methoxy-5-[ (1Z) -2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol 1-(dihydrogen phosphate) sodium salt; CA 4P. Grades: Highly Purified. CAS No. 168555-66-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C18H19Na2O8P. US Biological Life Sciences. | Worldwide |
| Combretastatin A-4 ( (Z) -2-Methoxy-5-[2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol, 3,4,5-Trimethoxy-3-hydroxy-4-methoxy-(Z)-stilbene, CS-A4) | Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Inducer. Group: Biochemicals. Alternative Names: (Z) -2-Methoxy-5-[2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol, 3,4,5-Trimethoxy-3-hydroxy-4-methoxy-(Z)-stilbene, CS-A4. Grades: Highly Purified. CAS No. 117048-59-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Combretastatin A-4 Phosphate, Disodium Salt (CA 4P) | Phosphorylated, Combretastatin a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Indu. Group: Biochemicals. Alternative Names: CA 4P. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Fosbretabulin | Fosbretabulin, also called as CA4P, has antitumor activity against anaplastic thyroid cancer (ATC) cell lines. Fosbretabulin, a novel water-soluble vascular-disrupting agent, is a phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum). Synonyms: [2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate; 3,4,5-trimethoxy-3'-hydroxy-4'-methoxystilbene; CA4DP; combretastatin A-4; 168555-66-6 (fosbretabulin disodium); 82855-09-2 (combretastatin); 117048 -59-6 (combretastatin A4). Grades: >98%. CAS No. 222030-63-9. Molecular formula: C18H21O8P. Mole weight: 396.33. |  |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Synonyms: Combretastatin A-4 phosphate disodium, CA4P; CA4DP; Combretastatin A-4 phosphate. CAS No. 168555-66-6. Molecular formula: C18H19Na2O8P. Mole weight: 440.295. | |
| Ombrabulin | Ombrabulin is a synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. Synonyms: AVE8062; AVE 8062; AC-7700; AC 7700; AC7700; CS-39-L-Ser.HCl; AVE-8062A; AVE-8062; RPR-258062A; RPR 258062A. CAS No. 181816-48-8. Molecular formula: C21H26N2O6. Mole weight: 402.45. | |
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