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| Product | Description | |
|---|---|---|
| CP-724714 | CP-724714 is An orally bioavailable quinazoline with potential antineoplastic activity. CP-724,714 selectively binds to the intracellular domain of HER2, reversibly inhibiting its tyrosine kinase activity and resulting in suppression of tumor cell growth. HER2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in many adenocarcinomas, particularly breast cancers. Synonyms: CP-724714; CP 724714; CP724714. CAS No. 383432-38-0. Molecular formula: C27H27N5O3. Mole weight: 469.545. |  |
| CP-724714 | CP-724714 is a potent, selective and orally active ErbB2 (HER2) tyrosine kinase inhibitor, with an IC 50 of 10 nM. CP-724714 displays a marked selectivity against EGFR kinase (IC 50 =6400 nM). CP-724714 potently inhibits ErbB2 receptor autophosphorylation in intact cells. Antitumor activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 383432-38-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14674. |  |
| (E/Z)-CP-724714 | (E/Z)-CP-724714 is a racemic compound of (E)-CP-724714 and (Z)-CP-724714 isomers. CP-724714 is a potent, selective and orally active ErbB2 (HER2) inhibitor with IC50 of 10 nM, and shows >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc. Synonyms: 2-Methoxy-N-{3-[4-({3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl}amino)-6-quinazolinyl]-2-propen-1-yl}acetamide; Acetamide, 2-methoxy-N-[3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-. Grade: >98%. CAS No. 537705-08-1. Molecular formula: C27H27N5O3. Mole weight: 469.53. | |
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