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| Product | Description | |
|---|---|---|
| CPI-455 | CPI-455 is a specific, pan- KDM5 inhibitor with an IC 50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628208-23-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100421. |  |
| CPI-455 hydrochloride | CPI-455 is a specific inhibitor of KDM5 with IC50 of 10 ± 1 nM for full-length KDM5A in enzymatic assays. Synonyms: 7-oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride. Grades: ≥99%. CAS No. 2095432-28-1. Molecular formula: C16H15ClN4O. Mole weight: 314.77. |  |
| CPI 455 | CPI 455 is a selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation (H3K4me3) in vitro and reduces survival of drug-tolerant cancer cells. Uses: Antitumor agent for drug-tolerant cancer. Synonyms: CPI-455; CPI-455; CPI-455; 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grades: 99%. CAS No. 1628208-23-0. Molecular formula: C16H14N4O. Mole weight: 278.31. | |
| KDM5-inhibitor | KDM5-inhibitor is an analog of CPI-455, a selective KDM5 inhibitor. CPI-455 increases levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell lines treated with standard chemotherapy or targeted agents. It reduces survival of drug-tolerant cancer cells. Synonyms: KDM5 inhibitor; 7-oxo-5-phenyl-6-propyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Molecular formula: C16H14N4O. Mole weight: 278.315. | |
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