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| Product | Description | |
|---|---|---|
| Cromakalim | Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL 34915. CAS No. 94470-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110011. |  |
| Cromakalim | Cromakalim is a prototypical Kir6 (KATP) channel opener. It is used as a potassium channel-opening vasodilator. It acts on ATP-sensitive potassium channels and causes membrane hyperpolarization. It displays cardioprotective and anti-ischemic effects in rat hearts. It can be used to treat hypertension because it will relax vascular smooth muscle to lower blood pressure. It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance. It is orally active in vivo. Synonyms: BRL 34915; BRL-34915; BRL34915; Cromakalim; (±)-Cromakalim; (±)-Cromakalim; (3R,4S)-rel-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile; trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile; (±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol. Grades: ≥99% by HPLC. CAS No. 94470-67-4. Molecular formula: C16H18N2O3. Mole weight: 286.33. |  |
| (+/-)-Cromakalim | (+/-)-Cromakalim. Group: Biochemicals. Alternative Names: [+/-]-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-[2-oxopyrrolidin-1-yl]-2H-1-benzopyran-3-ol; BRL 34915; (3R,4S)-rel-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile. Grades: Highly Purified. CAS No. 94470-67-4. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C16H18N2O3. US Biological Life Sciences. |  Worldwide |
| (+/-)-Cromakalim ([+/-]-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-[2-oxopyrrolidin-1-yl]-2H-1-benzopyran-3-ol) | Causes vasodilation by activation of potassim channels. Group: Biochemicals. Alternative Names: [+/-]-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-[2-oxopyrrolidin-1-yl]-2H-1-benzopyran-3-ol. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Levcromakalim | Levcromakalim ((-)-Cromakalim) is an ATP-sensitive K + channel (K ATP ) activator. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Cromakalim; BRL 38227. CAS No. 94535-50-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14255. | |
| Levcromakalim | LevCromakalim is an ATP-sensitive K+channel(KATP) activator used in the management of hypertension in diabetes mellitus. Synonyms: (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile; BRL 38226; BRL 38227; BRL-34915; BRL-38226; BRL-38227; BRL38226; BRL38227; Cromakalim; Cromakalim, (3R-cis)-Isomer; Cromakalim, (3R-trans)-Isomer; Cromakalim, (3S-cis)-Isomer; Cromakalim, (3S-trans)-Isomer; Cromakalim, (trans)-Isomer; Lemakalim; Levcromakalim. CAS No. 94535-50-9. Molecular formula: C16H18N2O3. Mole weight: 286.33. | |
| Glibornuride | Glibornuride is an anti-diabetic drug from the group of sulfonylureas. It has been shown to antagonize the relaxant response to the K+ channel opener cromakalim and produce airway smooth muscle relaxation. It is associated with lactic acidosis and hypoglycemia in patients with type 2 diabetes melitus. Uses: Anti-diabetic drug. Synonyms: 1-[(1S,2S,3R,4R)-3-hydroxy-4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]-3-(4-methylphenyl)sulfonylurea. Grades: > 98%. CAS No. 26944-48-9. Molecular formula: C18H26N2O4S. Mole weight: 366.476. | |
| U89232 | U89232, a cardioselective cyanoguanidine analog of cromakalim, appears to be a cardioselective KATP channel opener. Synonyms: 1-cyano-2-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-(2-methylbutan-2-yl)guanidine; Guanidine, N-cyano-N'-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-N''-(1,1-dimethylpropyl)-, trans-; trans-N-cyano-N'-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-N''-(1,1-dimethylpropyl)guanidine; U 89232; U-89232. CAS No. 134017-78-0. Molecular formula: C19H25N5O2. Mole weight: 355.43. | |
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