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| Product | Description | |
|---|---|---|
| CRT | CRT, an iron peptide mimic, can bind to apo-transferrin ( apo-Tf ). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency [1]. Uses: Scientific research. Group: Peptides. CAS No. 2414254-70-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5533. |  |
| CRT0044876 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| CRT0066101 | CRT0066101 is a potent and orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM and 2 nM for PKD1 , PKD2 , and PKD3 , respectively [1]. CRT0066101 is also a potent PIM2 inhibitor with an IC 50 of ~135.7?nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956123-34-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-15698. | |
| CRT0066101 | CRT0066101 is a small-molecule protein kinase D (PKD) inhibitor that suppresses PDK1, PDK2 and PDK3 (PDK1: IC50 = 1 nM; PDK2: IC50 = 2.5 nM; PDK3: IC50 = 2 nM). Studies in vivo showed that CRT0066101 inhibited pancreatic cancer growth. Synonyms: Phenol, 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-, hydrochloride (1:2); (R)-2-(4-((2-Aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride; 2-(4-{[(2R)-2-Aminobutyl]amino}pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride; CRT 0066101; CRT-0066101; CRT0066101 dihydrochloride. Grades: ≥95%. CAS No. 1883545-60-5. Molecular formula: C18H22N6O.2HCl. Mole weight: 411.33. |  |
| CRT 0066101 | Potent inhibitor of protein kinase D (PKD); inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5nM for PKD1, PKD3 and PKD2 respectively). Exhibits selectivity for PKD against a panel of >90 protein kinases, including PKC-alpha, MEK, ERK, c-Raf and c- Src. Reduces proliferation and cell viability of pancreatic cancer cells expressing moderate levels of endogenous PKD1/2. Orally bioavailable. Group: Biochemicals. Alternative Names: 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride. Grades: Purified. CAS No. 1883545-60-5. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CRT0066101 dihydrochloride | CRT0066101 dihydrochloride is a potent and orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM and 2 nM for PKD1 , PKD2 , and PKD3 , respectively [1]. CRT0066101 dihydrochloride is also a potent PIM2 inhibitor with an IC 50 of ~135.7?nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883545-60-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15698A. | |
| CRT0066101 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CRT0066101 hydrochloride | CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively). It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl. Synonyms: Phenol, 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-, hydrochloride (1:3); (R)-2-(4-((2-Aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol trihydrochloride; 2-(4-{[(2R)-2-Aminobutyl]amino}pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol trihydrochloride. Grades: ≥95%. CAS No. 1781742-22-0. Molecular formula: C18H22N6O.3HCl. Mole weight: 447.79. | |
| CRT0066854 | CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCΙ , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1438881-19-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18713. | |
| CRT0066854 | CRT0066854 is a selective and ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM for full-length PKCζ, PKCΙ, respectively). CRT0066854 decreases colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. Synonyms: CRT0066854; CRT 0066854; CRT-0066854; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine. Grades: 99%. CAS No. 1438881-19-6. Molecular formula: C24H25N5S. Mole weight: 415.55. | |
| CRT 0066854 hydrochloride | The hydrochloride salt form of CRT 0066854, which has been found to be a PKC inhibitor. Synonyms: CRT 0066854 hydrochloride; CRT0066854 hydrochloride; CRT-0066854 hydrochloride; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C24H25N5S.2HCl. Mole weight: 488.48. | |
| CRT0066854 hydrochloride | CRT0066854 hydrochloride is a potent and selective atypical PKC s inhibitor. CRT0066854 is against full-length (FL) PKCΙ , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2250019-91-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18713A. | |
| CRT 0105950 | CRT 0105950 is a potent inhibitor of LIMK1/2 (IC50 = 0.3 and 1 nM at LIMK 1 and 2, respectively). It disrupts microtubule organization, inhibits phosphorylation of cofilin and increases α-tubulin acetylation in vitro. Synonyms: 4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol. Grades: ≥98% by HPLC. CAS No. 1661845-86-8. Molecular formula: C21H16ClN3OS. Mole weight: 393.89. | |
| CRT5 | CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively) in endothelial cells treated with VEGF. Synonyms: CRT0066051. Grades: ≥98%. CAS No. 1034297-58-9. Molecular formula: C28H30N4O2. Mole weight: 454.6. | |
| Anti-CRTH2 (GPR44) antibody produced in chicken | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-CRTH2 (GRP44) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| DP2 Antagonist I (CRTH2 Antagonist I, GPR44 Antagonist I, (4-Chloro-2- ( (2-methyl-5- (propylsulfonyl) phenyl) ethynyl) phenoxy) acetic Acid) | A cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 2.0 and 2.4nM against 1.5nM PGD2 for human & murine DP2 binding, respectively), exhibiting much reduced potency against DP1 (Ki = 1.58uM; IC50 = 10uM), PGE receptor EP2 (54% inhibition at 10uM), and little or no activity toward 49 other receptors and ion channels. Effectively inhibits PGD2-induced cellular activation (IC50 = 32 and 80nM, respectively, using CHO-CRTH2 or human whole blood) in vitro and is efficacious in alleviating airway eosinophil infiltration in OVA-sensitized mice (30mg/kg; p.o.) in vivo with good oral bioavailability. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??ClO?S. US Biological Life Sciences. | Worldwide |
| DP2 Antagonist II (CRTH2 Antagonist II, GPR44 Antagonist II, (R)-(5-Chloro-1'-(5-chloro-2-fluorobenzyl)-2,2',5'-trioxospiro(indole-3,3?-pyrrolidin)-1(2H)-yl)acetic Acid) | The (R) enantiomer of a cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 5.3 and 5.0nM against human & murine DP2, respectively), exhibiting much reduced potency against a panel of more than 50 other receptors and ion channels. Effectively inhibits DP2-dependent chemotaxis of primary human eosinophils (IC50 = 100nM). Exhibits higher Caco-2 permeability than DP2 Antagonist I, but less oral bioavailability in mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??Cl?FN?O?. US Biological Life Sciences. | Worldwide |
| iCRT 14 | iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling. It is thought to directly influence the interaction between β-catenin and TCF4. It also induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Synonyms: iCRT14; iCRT-14; iCRT 14; Wnt inhibitor; CHEMBL3589010; STK155594; 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione. Grades: >98%. CAS No. 677331-12-3. Molecular formula: C21H17N3O2S. Mole weight: 375.44. | |
| iCRT-14 | A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Group: Biochemicals. Alternative Names: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione; iCRT 14; iCRT14. Grades: Highly Purified. CAS No. 677331-12-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| iCRT5 | iCRT5 is a Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor (IC50 value of 18 nM for Wnt responsive STF16 luciferase). iCRT5 disrupts the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin. Synonyms: iCRT5; iCRT-5; iCRT 5; 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid; 4-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid; EN300-00774; AC1Q49FJ. Grades: 99%. CAS No. 18623-44-4. Molecular formula: C16H17NO5S2. Mole weight: 367.44. | |
| 13,14-Dihydro-15-keto-PGD2 | 13,14-Dihydro-15-keto-PGD2 is a metabolite of prostaglandin D2 and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 59894-07-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H32O5, Molecular Weight: 352.47. US Biological Life Sciences. | Worldwide |
| 1-(4-Fluorophenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid | 1-(4-Fluorophenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid is used as a reagent in the synthesis of a new class of 7-azaindole analogs of MK-7246 (M425045) as potent and selective CRTH2 antagonists for the treatment of respiratory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 915921-31-2. Pack Sizes: 50mg, 500mg. Molecular Formula: C12H13FO2, Molecular Weight: 208.23. US Biological Life Sciences. | Worldwide |
| 1- (4-Fluorophenyl) -N- [3- (1H-imidazol-1-yl) propyl ] -2, 2-di methyl -cyclopropane carboxamide | 1- (4-Fluorophenyl) -N- [3- (1H-imidazol-1-yl) propyl ] -2, 2-di methyl -cyclopropane carboxamide has therapeutic uses. It is synthesized from 1-(4-Fluorophenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid (F595430), which is used as a reagent in the synthesis of a new class of 7-azaindole analogs of MK-7246 (M425045) as potent and selective CRTH2 antagonists for the treatment of respiratory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1434927-54-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C18H22FN3O, Molecular Weight: 315.39. US Biological Life Sciences. | Worldwide |
| 15(R)-15-Methyl prostaglandin D2 | 15(R)-15-Methyl PGD2 is a selective, potent agonist for the CRTH2/DP2 receptor. Synonyms: 15(R)-15-methyl PGD2; 15(R)-15-methyl Prostaglandin D2. Grades: ≥95%. CAS No. 210978-26-0. Molecular formula: C21H34O5. Mole weight: 366.5. | |
| 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase | The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the desaturation of the C-3,4 double bond in dihydroisopentenyldehydrorhodopin and the desaturation of the C-3',4' double bond in dihydrobisanhydrobacterioruberin. Group: Enzymes. Synonyms: crtD (gene name). Enzyme Commission Number: EC 1.3.99.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1437; 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase; EC 1.3.99.37; crtD (gene name). Cat No: EXWM-1437. |  |
| 1-hydroxycarotenoid 3,4-desaturase | The enzymes from Rubrivivax gelatinosus and Rhodobacter sphaeroides prefer the acyclic carotenoids (e.g. 1-hydroxy-1,2-dihydroneurosporene, 1-hydroxy-1,2-dihydrolycopene) as substrates. The conversion rate for the 3,4-desaturation of the monocyclic 1'-hydroxy-1',2'-dihydro-γ-carotene is lower. The enzyme from the marine bacterium strain P99-3 shows high activity with the monocyclic carotenoid 1'-hydroxy-1',2'-dihydro-γ-carotene. The enzyme from Rhodobacter sphaeroides utilizes molecular oxygen as the electron acceptor in vitro. However, oxygen is unlikely to be the natural electron acceptor under anaerobic conditions. Group: Enzymes. Synonyms: CrtD; hydroxyneurosporene desaturase; carotenoid 3,4-dehydrogenase; 1-hydroxy-carotenoid 3,4-dehydrogenase. Enzyme Commission Number: EC 1.3.99.27. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1429; 1-hydroxycarotenoid 3,4-desaturase; EC 1.3.99.27; CrtD; hydroxyneurosporene desaturase; carotenoid 3,4-dehydrogenase; 1-hydroxy-carotenoid 3,4-dehydrogenase. Cat No: EXWM-1429. | |
| 2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine ruthenium(II) carbonyl | 2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine ruthenium(II) carbonyl. Group: other materials. Alternative Names: Carbon monoxide; 2,3,7,8,12,13,17,18-octaethylporphyrin-22,24-diide; ruthenium(2+). CAS No. 41636-35-5. Product ID: carbon monoxide; 2,3,7,8,12,13,17,18-octaethyl-1,4,5,10,11,14,15,20,21,23-decahydroporphyrin-22,24-diide; ruthenium(2+). Molecular formula: 661.8. Mole weight: C37H44N4ORu. CCC1=C (C2=CC3=NC (=CC4=C (C (=C ([N-]4)C=C5C (=C (C (=N5)C=C1[N-]2)CC)CC)CC)CC)C (=C3CC)CC)CC. [C-]#[O+]. [Ru+2]. InChI=1S/C36H44N4. CO. Ru/c1-9-21-22 (10-2)30-18-32-25 (13-5)26 (14-6)34 (39-32)20-36-28 (16-8)27 (15-7)35 (40-36)19-33-24 (12-4)23 (11-3)31 (38-33)17-29 (21)37-30; 1-2; /h17-20H, 9-16H2, 1-8H3; /q-2; +2. CRTFSNIGJRIMPF-UHFFFAOYSA-N. |  |
| 2-Methyl-4-nitroindole | 2-Methyl-4-nitroindole is a useful synthetic intermediate in the synthesis of AZD1981, a CRTH2 receptor antagonist used in patients with moderate to severe COPD. 2-Methyl-4-nitroindole is also used as a reagent in the preparation of anti-angiogenic pyrroloazaflavones. Group: Biochemicals. Grades: Highly Purified. CAS No. 3484-10-4. Pack Sizes: 50mg, 250mg. Molecular Formula: C9H8N2O2, Molecular Weight: 176.17. US Biological Life Sciences. | Worldwide |
| 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming) | The enzyme catalyses four successive dehydrogenations, resulting in production of 4,4'-diapolycopene. While the enzyme from Staphylococcus aureus was only shown to produce 4,4'-diaponeurosporene in vivo, it is able to catalyse the last reaction in vitro. Group: Enzymes. Synonyms: dehydrosqualene desaturase (ambiguous); CrtN (ambiguous); 4,4'-diapophytoene:FAD oxidoreductase (ambiguous); 15-cis-4,4'-diapophytoene:FAD oxidoreductase; 4,4'-diapophytoene desaturase (ambiguous). Enzyme Commission Number: EC 1.3.8.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1409; 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming); EC 1.3.8.2; dehydrosqualene desaturase (ambiguous); CrtN (ambiguous); 4,4'-diapophytoene:FAD oxidoreductase (ambiguous); 15-cis-4,4'-diapophytoene:FAD oxidoreductase; 4,4'-diapophytoene desaturase (ambiguous). Cat No: EXWM-1409. | |
| 4,4'-diapophytoene synthase | Requires Mn2+. Typical of Staphylococcus aureus and some other bacteria such as Heliobacillus sp. Group: Enzymes. Synonyms: dehydrosqualene synthase; DAP synthase; C30 carotene synthase; CrtM. Enzyme Commission Number: EC 2.5.1.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2835; 4,4'-diapophytoene synthase; EC 2.5.1.96; dehydrosqualene synthase; DAP synthase; C30 carotene synthase; CrtM. Cat No: EXWM-2835. | |
| 7-Nitroindole-2-carboxylic acid | CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM. Synonyms: 1H-Indole-2-carboxylic acid, 7-nitro-; CRT0044876; CRT-0044876; CRT 0044876; NSC 69877; NSC-69877; NSC69877; 7-Nitro-2-indolecarboxylic Acid. Grades: ≥98%. CAS No. 6960-45-8. Molecular formula: C9H6N2O4. Mole weight: 206.15. | |
| all-trans-ζ-carotene desaturase | This enzyme is involved in carotenoid biosynthesis. Group: Enzymes. Synonyms: Crtlb; phytoene desaturase (ambiguous); 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous); CrtI (ambiguous). Enzyme Commission Number: EC 1.3.99.26. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1428; all-trans-ζ-carotene desaturase; EC 1.3.99.26; Crtlb; phytoene desaturase (ambiguous); 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous); CrtI (ambiguous). Cat No: EXWM-1428. | |
| AMG-009 | AMG-009 is an orally active, small molecule dual D prostanoid(DP) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. It was in preclinical development for the treatment of asthma and allergic rhinitis. It was developed by Amgen Inc. Uses: Amg-009 was in preclinical development for the treatment of asthma and allergic rhinitis. Synonyms: AMG-009; AMG 009; AMG009; 2-[4-[4- (Butylcarbamoyl) -2-[ (2, 4-dichlorophenyl) sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acid;AMG009;Benzeneacetic acid, 4- (4- ( (butylamino) carbonyl) -2- ( ( (2, 4-dichlorophenyl) sulfonyl) amino) phenoxy) -3-methoxy-. Grades: >98 %. CAS No. 1027847-67-1. Molecular formula: C26H26Cl2N2O7S. Mole weight: 581.46. | |
| AZ11665362 | AZ11665362 is a potent CRTH2 antagonist. It blocks the migration of eosinophils and basophils, and the rapid mobilization of eosinophils from bone marrow. It might be useful for the treatment of allergic diseases. Uses: Az11665362 might be useful for the treatment of allergic diseases. Synonyms: AZ-11665362; AZ 11665362; AZ11665362; (2,5-Dimethyl-3-(8-methyl-4-quinolinyl)-1H-indol-1-yl)acetic acid. Grades: 98%. CAS No. 629645-40-5. Molecular formula: C22H20N2O2. Mole weight: 344.41. | |
| AZD1981 | AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8. Uses: Scientific research. Group: Signaling pathways. CAS No. 802904-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15950. | |
| β-carotene 3-hydroxylase | Requires ferredoxin and Fe(II). Also acts on other carotenoids with a β-end group. In some species canthaxanthin is the preferred substrate. Group: Enzymes. Synonyms: β-carotene 3,3'-monooxygenase; CrtZ. Enzyme Commission Number: EC 1.14.13.129. CAS No. 133425-64-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0729; β-carotene 3-hydroxylase; EC 1.14.13.129; 133425-64-6; β-carotene 3,3'-monooxygenase; CrtZ. Cat No: EXWM-0729. | |
| BI671800 | BI671800 is a CRTH2 antagonist. It is used to treat patients with asthma. It is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on inhaled corticosteroid (ICS) therapy. Uses: Bi671800 is used to treat patients with asthma. Synonyms: AP-761; AP 761; AP761; 5-Pyrimidineacetic acid, 4, 6-bis (dimethylamino) -2-[[4-[[4- (trifluoromethyl) benzoyl]amino]phenyl]methyl]-; 2- (4, 6-Bis (dimethylamino) -2- (4- (4- (trifluoromethyl) benzamido) benzyl) pyrimidin-5-yl) acetic acid; BI-671800; BI 671800; BI671800. Grades: >98%. CAS No. 1093108-50-9. Molecular formula: C25H26F3N5O3. Mole weight: 501.51. | |
| carotenoid 1,2-hydratase | In Rubrivivax gelatinosus and Thiocapsa roseopersicina both products are formed, whereas Rhodobacter capsulatus only gives 1-hydroxy-1,2-dihydrolycopene. Also acts on neurosporene giving 1-hydroxy-1,2-dihydroneurosporene with both organism but 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene only with Rubrivivax gelatinosus. Group: Enzymes. Synonyms: CrtC. Enzyme Commission Number: EC 4.2.1.131. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4972; carotenoid 1,2-hydratase; EC 4.2.1.131; CrtC. Cat No: EXWM-4972. | |
| CAY10471 | CAY10471 is an analog of BAY-u3405, which contains modifications that increase both its potency and selectivity for the human CRTH2/DP2 receptor. CAY10471 binds to the human DP1 with Ki of 1200 nM and DP2 with Ki of 0.6 nM. It also show very high binding affinity with TP, which Ki can higher than 10,000 nM. Synonyms: CAY-10471; CAY 10471; TM-30089; TM 30089. Grades: ≥95%. CAS No. 627865-18-3. Molecular formula: C21H21FN2O4S. Mole weight: 416.5. | |
| CAY10595 | Chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) is a G-protein coupled receptor that binds to the ligand prostaglandin D2 (PGD2).The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. CAY10595 is a mixture of isomers which acts as a potent CRTH2/DP2 receptor antagonist with Ki of 10 nM. Synonyms: CAY 10595; CAY-10595. Grades: ≥97%. CAS No. 916047-16-0. Molecular formula: C20H13Cl2FN2O5. Mole weight: 451.2. | |
| CAY10597 | The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. Synonyms: CAY 10597; CAY-10597. Grades: ≥98%. CAS No. 916046-55-4. Molecular formula: C20H14ClFN2O5. Mole weight: 416.8. | |
| demethylspheroidene O-methyltransferase | In Rhodopseudomonas capsulata and Rubrivivax gelatinosus the enzyme is involved in biosynthesis of spheroidene. In Rubrivivax gelatinosus the enzyme also catalyses the methylation of demethylspirilloxanthin to spirilloxanthin and the methylation of 3,4-didehydrorhodopin to anhydrorhodovibrin. Group: Enzymes. Synonyms: 1-hydroxycarotenoid O-methylase; 1-hydroxycarotenoid methylase; 1-HO-carotenoid methylase; CrtF. Enzyme Commission Number: EC 2.1.1.210. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1812; demethylspheroidene O-methyltransferase; EC 2.1.1.210; 1-hydroxycarotenoid O-methylase; 1-hydroxycarotenoid methylase; 1-HO-carotenoid methylase; CrtF. Cat No: EXWM-1812. | |
| diapolycopene oxygenase | Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes eachmethyl group to the hydroxymethyl and then a dihydroxymethyl group,followed by the spontaneous loss of water to give an aldehyde group. Group: Enzymes. Synonyms: crtP (ambiguous). Enzyme Commission Number: EC 1.14.99.44. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1054; diapolycopene oxygenase; EC 1.14.99.44; crtP (ambiguous). Cat No: EXWM-1054. | |
| Dysprosium | Dysprosium. Uses: There are not many uses for dysprosium. scientists continue to experiment with it as apossible alloy metal (it has a high melting point) to be mixed with steel to make control rodsthat absorb neutrons in nuclear reactors. there are only a few commercial uses for dysprosium,such as a laser material and as a fluorescence activator for the phosphors used to produce thecolors in the older tv and computer cathode ray tubes (crts). when combined with steelor nickel as an alloy, it makes strong magnets. Additional or Alternative Names: Dysprosium, plasma standard solution, Specpure(R), Dy 10,000microg/ml; Dysprosium, powder, 5g, max. particle size 500 micron, 99.9%; TRA-0193167; Dysprosium rod, 6.35mm (0.25in) dia; Dysprosium foil, 3N; Dysprosium, foil, thickness 0.2 mm, size 25 x 75 mm, purity 99%; Dysprosium, wire reel, 100mm, diameter 1.0mm, hard, 99.9%; Dysprosium, foil, thickness 0.50 mm, size 50 x 50 mm, tolerance 0.2; Dysprosium, foil, 100x100mm, thickness 0.125mm, as rolled, 99%; Dysprosium pieces, distilled dendritic. Product Category: Nanoparticles & Nanopowders. CAS No. 7429-91-6. Molecular formula: Dy. Mole weight: 162.5g/mol. IUPACName: dysprosium. Canonical SMILES: [Dy]. ECNumber: 231-073-9. Product ID: ACM7429916. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Fevipiprant | Fevipipran is a reversible competitive CRTh2 antagonist with IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood. Now it is in Phase III clinical trials for the treatment of asthma. Uses: Allergic asthma; atopic dermatitis. Synonyms: NVP-QAW039; NVP-QAW 039; NVP-QAW-039 QAW-039; QAW039; QAW 039; Fevipiprant; 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid. Grades: 98%. CAS No. 872365-14-5. Molecular formula: C19H17F3N2O4S. Mole weight: 426.41. | |
| IKK epsilon/TBK1 Inhibitor II, MRT67307 (TANK Binding Kinase 1/IKKinducible Inhibitor II, N- (3- (5-Cyclopropyl -2- (3- (morpholino methyl ) phenylamino) pyrimidin-4-ylamino) propyl ) cyclobutane carboxamide) | A cell-permeable BX795 analog that acts as a potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKK epsilon (IC50 = 19 and 160nM, respectively) with excellent selectivity over IKKalpha and IKKbeta (IC50 > 10uM). Interacts with the TBK1 kinase dimer interface and stabilizes the inactive DFG-out conformation. Also blocks the activity of MARK (microtubule- associated protein (MAP)-microtubule affinity regulating kinase) 1, 2, 3, and 4 (IC50 = 27, 52, 36, and 41nM, respectively), SIK2 (IC50 = 67nM) and Aurora B, JAK2, and MLK1,3 (> than 90% inhibition at 1uM) in a 108-kinase panel. Increases TNF-alpha-stimulated NF-kB-dependent gene transcription in wild-type macrophages and enhances CREB-dependent gene transcription by promoting dephosphorylation of CREB-regulated transcription coactivator (CRTC3). Shown to aid TLR-stimulated production of anti-Inflammatory cytokines in macrophages while suppressing the secretion of pro-inflammatory cytokines. In response to pro-inflamm Group: Biochemicals. Grades: Highly Purified. CAS No. 495-85-2. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| LAS191859 | LAS191859 is a potent antagonist of chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTh2), a G protein-coupled receptor most expressed on the leukocytes. LAS191859 is identified as a treatment of asthma and allergy. Synonyms: 1-[2-[[ (cyclopropylcarbonyl) ethylamino]methyl]-4- (trifluoromethyl) phenyl]-6-methyl-1H-pyrrolo[2, 3-b]pyridine-3-aceticacid. Grades: ≥98%. CAS No. 1420071-13-1. Molecular formula: C24H24F3N3O3. Mole weight: 459.5. | |
| lycopene β-cyclase | The enzyme is a non-redox flavoprotein, containing FADH2 that is used for stabilization of a transition state. Lycopene has a ψ-end group at both ends. When acting on one end, the enzyme forms γ-carotene. When acting on both ends it forms β-carotene. It also acts on neurosporene to give β-zeacarotene. Group: Enzymes. Synonyms: CrtL; CrtL-b; CrtY; LCYb; carotenoid β-end group lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.19. CAS No. 220801-82-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5620; lycopene β-cyclase; EC 5.5.1.19; 220801-82-1; CrtL; CrtL-b; CrtY; LCYb; carotenoid β-end group lyase (decyclizing). Cat No: EXWM-5620. | |
| lycopene ε-cyclase | The carotenoid lycopene has the ψ-end group at both ends. When acting on one end, this enzyme forms Δ-carotene. When acting on both ends, it forms ε-carotene. Group: Enzymes. Synonyms: CrtL-e; LCYe; carotenoid ψ-end group lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.18. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5619; lycopene ε-cyclase; EC 5.5.1.18; CrtL-e; LCYe; carotenoid ψ-end group lyase (decyclizing). Cat No: EXWM-5619. | |
| Maropitant | Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 147116-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10053. | |
| Methyl Bromoacetate | Methyl Bromoacetate is an organic building block that has been used as a reactant in the preparation of isoquinolinone indole acetic acid derivatives as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. Group: Polymerization reagents. CAS No. 96-32-2. Product ID: methyl 2-bromoacetate. Molecular formula: 152.97g/mol. Mole weight: C3H5BrO2. COC(=O)CBr. InChI=1S/C3H5BrO2/c1-6-3(5)2-4/h2H2, 1H3. YDCHPLOFQATIDS-UHFFFAOYSA-N. | |
| MK-7246 | This active molecular is a selective chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist and is used for the treatment of respiratory tract disorders originated by Merck & Co. CRTH2 is a G protein-coupled receptor that has been reported to modulate inflammatory responses in animal models of asthma, allergic rhinitis and atopic dermatitis. No recent reports of development identified for phase-I development in Respiratory-tract-disorders in USA were published yet. Uses: Respiratory tract disorders. Synonyms: MK-7246; MK 7246; MK7246; (7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-acetic Acid. Grades: 98%. CAS No. 1218918-62-7. Molecular formula: C21H21FN2O4S. Mole weight: 416.47. | |
| Neodymium Fluoride | Neodymium Fluoride is mainly used for glass, crystal and capacitors, and is the main raw material for making Neodymium Metal and alloys. Neodymium has a strong absorption band centered at 580 nm, which is very close to the human eye's maximum level of sensitivity making it useful in protective lenses for welding goggles. It is also used in CRT displays to enhance contrast between reds and greens. It is hHighly valued in glass manufacturing for its attractive purple coloring to glass. Group: Optical coatings. Alternative Names: Neodymium trifluoride. CAS No. 13709-42-7. Product ID: Trifluoroneodymium. Molecular formula: 201.24. Mole weight: NdF3. F[Nd](F)F. InChI=1S/3FH.Nd/h3*1H;/q;+3/p-3. XRADHEAKQRNYQQ-UHFFFAOYSA-K. 99%+. | |
| Neodymium(III) chloride | Neodymium(III) chloride. Uses: Neodymium chloride mainly used for glass, crystal and capacitors. colours glass delicate shades ranging from pure violet through wine-red and warm gray. light transmitted through such glass shows unusually sharp absorption bands. it is useful in protective lenses for welding goggles. it is also used in crt displays to enhance contrast between reds and greens. it is highly valued in glass manufacturing for its attractive purple coloring to glass. Group: Electrolytes. Alternative Names: Neodymium trichloride; NEODYMIUM(III) CHLORIDE; NEODYMIUM CHLORIDE; NdCl3; Neodymium chloride (NdCl3); neodymiumchloride(ndcl3); Neodymium (III) chloride, anhydrous; NEODYMIUM(III) CHLORIDEANHYDROUSBEA. CAS No. 10024-93-8. Molecular formula: 250.60. Mole weight: NdCl3. | |
| Neodymium(III) hydroxide | Neodymium(III) hydroxide. Uses: Neodymium hydroxide, mainly used for catalyst, glass, crystal and capacitors. colours glass delicate shades ranging from pure violet through wine-red and warm gray. light transmitted through such glass shows unusually sharp absorption bands. it is also used in crt displays to enhance contrast between reds and greens. it is highly valued in glass manufacturing for its attractive purple coloring to glass. Group: Electrolytes. Alternative Names: NEODYMIUM HYDROXIDE; NEODYMIUM (III) HYDROXIDE; NEODYMIUM(III) HYDROXIDE HYDRATE; neodymium trihydroxide; NEODYMIUM(III) HYDROXIDE HYDRATE, 99.99&; neodymiumhydroxide99.9%; Neodymium(III) hydroxide hydrate (REO); Neodymium(III) hydroxide hydrate, 99% (REO). CAS No. 16469-17-3. Product ID: neodymium(3+); trihydroxide. Molecular formula: 195.26g/mol. Mole weight: Nd(OH)3;H3NdO3. [OH-].[OH-].[OH-].[Nd+3]. InChI=1S/Nd.3H2O/h;3*1H2/q+3;;;/p-3. ZBAQHMBLDSQPHC-UHFFFAOYSA-K. | |
| Neodymium Oxalate | Neodymium Oxalate, mainly used for catalyst, glass, crystal and capacitors. Colours glass delicate shades ranging from pure violet through wine-red and warm gray. LHight transmitted through such glass shows unusually sharp absorption bands. It is useful in protective lenses for welding goggles. It is also used in CRT displays to enhance contrast between reds and greens. It is hHighly valued in glass manufacturing for its attractive purple coloring to glass. Uses: Mainly used for catalyst, glass, crystal and capacitors. colours glass delicate shades ranging from pure violet through wine-red and warm gray. light transmitted through such glass shows unusually sharp absorption bands. Additional or Alternative Names: [mu-[ethanedioato(2-)-o,o''':o',o'']]bis[ethanedioato(2-)-o,o']di-neodymiu;NEODYMIUM OXALATE;tris[oxalato(2-)]dineodymium;neodymium(III) oxalate;Neodymiem oxalate;neodymium(3+). Product Category: Heterocyclic Organic Compound. Appearance: Light purple powder. CAS No. 1186-50-1. Molecular formula: Nd2(C2O4)3.xH2O. Mole weight: 553g/mol. Product ID: ACM1186501. Alfa Chemistry ISO 9001:2015 Certified. | |
| Neodymium Sulfate | Neodymium Sulfate, also Neodymium Sulphate, mainly used for catalyst, glass, crystal and capacitors. Colours glass delicate shades ranging from pure violet through wine-red and warm gray. LHight transmitted through such glass shows unusually sharp absorption bands. The glass is used in astronomical work to produce sharp bands by which spectral lines may be calibrated. It is also used in CRT displays to enhance contrast between reds and greens. It is hHighly valued in glass manufacturing for its attractive purple coloring to glass. Uses: Neodymium sulphate, mainly used for catalyst, glass, crystal and capacitors. colours glass delicate shades ranging from pure violet through wine-red and warm gray. light transmitted through such glass shows unusually sharp absorption bands. Product Category: Heterocyclic Organic Compound. Appearance: Rose crystalline. CAS No. 13477-91-3. Molecular formula: Nd2(SO4)3.8H2O. Mole weight: 721g/mol. Density: g/cm³. Product ID: ACM13477913. Alfa Chemistry ISO 9001:2015 Certified. | |
| NVP-QAV680 | NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM by 3H-PGD2 filtration binding assay. Synonyms: QAV-690 free acid; QAV690 free acid; QAV 690 free acid; NVP-QAV680; NVP ; NVPQAV680; NVP-QAV-680. Grades: >98%. CAS No. 872365-16-7. Molecular formula: C18H18N2O4S. Mole weight: 358.41. | |
| phytoene desaturase (lycopene-forming) | Requires FAD. The enzyme is involved in carotenoid biosynthesis and catalyses up to four desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.29 [phytoene desaturase (ζ-carotene-forming)] and EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)]). Group: Enzymes. Synonyms: 4-step phytoene desaturase; four-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous). Enzyme Commission Number: EC 1.3.99.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1433; phytoene desaturase (lycopene-forming); EC 1.3.99.31; 4-step phytoene desaturase; four-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous). Cat No: EXWM-1433. | |
| phytoene desaturase (neurosporene-forming) | This enzyme is involved in carotenoid biosynthesis and catalyses up to three desaturation steps (cf. EC 1.3.99.29 [phytoene desaturase (ζ-carotene-forming)], EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)], EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]). The enzyme is activated by FAD. NAD+, NADP+ or ATP show no activating effect. Group: Enzymes. Synonyms: 3-step phytoene desaturase; three-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous). Enzyme Commission Number: EC 1.3.99.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1430; phytoene desaturase (neurosporene-forming); EC 1.3.99.28; 3-step phytoene desaturase; three-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous). Cat No: EXWM-1430. | |
| phytoene desaturase (ζ-carotene-forming) | The enzyme is involved in carotenoid biosynthesis and catalyses up to two desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)] and EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]). Group: Enzymes. Synonyms: CrtIa; 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous). Enzyme Commission Number: EC 1.3.99.29. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1431; phytoene desaturase (ζ-carotene-forming); EC 1.3.99.29; CrtIa; 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous). Cat No: EXWM-1431. | |
| PKC Activator VII, CGK062 (Protein Kinase C Activator VII) | A cell permeable coumarin-containing compound that is shown to activate PKCalpha activity and induce cellular PKCalpha membrane translocation (Effective conc. 12.5 to 50uM) as well as PKCalpha-mediated signaling events. Effectively affects the viability of CRT-dependent cancer cells (IC50 = 1.62 to 18.6uM; 48h) in vitro and suppresses PC3-derived tumor expansion in mice (50 & 100mg/kg/day; i.p) in vivo, while exhibiting little cytotoxicity toward WI38 normal fibroblasts. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??O?, Primary Target IC50: 12.2uM. US Biological Life Sciences. | Worldwide |
| prolycopene isomerase | Requires FADH2. The enzyme is involved in carotenoid biosynthesis. Group: Enzymes. Synonyms: CRTISO; carotene cis-trans isomerase; ZEBRA2 (gene name); carotene isomerase; carotenoid isomerase. Enzyme Commission Number: EC 5.2.1.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5444; prolycopene isomerase; EC 5.2.1.13; CRTISO; carotene cis-trans isomerase; ZEBRA2 (gene name); carotene isomerase; carotenoid isomerase. Cat No: EXWM-5444. | |
| Prostaglandin A1 | Prostaglandin A1 can inhibit HIV-1 replication in various cell types. It can also activate pro-inflammatory PGD2 receptor CRTH2 initiating the anti-inflammatory response. Uses: Antiviral agents. Synonyms: 2-(3-Hydroxy-1-octenyl)-5-oxo-3-cyclopentene-1-heptanoic Acid; 15-Hydroxy-9-oxoprosta-10,13-dienoic Acid; 15α-Hydroxy-9-ketoprosta-10,13-dienoic Acid; 15α-Hydroxy-9-oxo-10,13E-prostadienoic Acid; PGA1; Prostaglandin A1; Prostaglandin E1-217. Grades: > 95%. CAS No. 14152-28-4. Molecular formula: C20H32O4. Mole weight: 336.48. | |
| Ramatroban | Ramatroban is a selective thromboxane A 2 ( TxA 2 , IC 50 =14 nM) antagonist, which also antagonizes CRTH2 ( IC 50 =113 nM) by inhibiting PGD 2 binding. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY u3405. CAS No. 116649-85-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0745. | |
| Setipiprant | Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC 50 value of 6 nM. Setipiprant inhibits prostanoid receptors h DP 1 and h EP 2 with IC 50 values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-129968; KYTH-105. CAS No. 866460-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16635. | |
| Setipiprant | Setipiprant is a potent, orally available and selective CRTH2 antagonist, which is a G protein-coupled receptor for PGD2. It may be a promising target for the treatment of allergic disorders. It was well tolerated and reduced both the allergen-induced LAR and the associated AHR in allergic asthmatics at multiple oral doses. It is a drug originally developed by Actelion, but it failed to show sufficient advantages and was discontinued from further development in this application. Later it was developed as a novel treatment for baldness by Kythera. Uses: Setipiprant may be a promising target for the treatment of allergic disorders. Synonyms: ACT-129968; ACT 129968; ACT129968; 2-(2-(1-naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid;ACT129968;2-[8-fluoro-2-(naphthalene-1-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid;8-Fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid; KYTH-105; KYTH105; KYTH 105. Grades: >98 %. CAS No. 866460-33-5. Molecular formula: C24H19FN2O3. Mole weight: 402.42. | |
| short-chain-enoyl-CoA hydratase | The enzyme from the bacterium Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents. It is specific for short, C4-C6, chain length substrates and exhibits an extremely high turnover number for crotonyl-CoA. cf. EC 4.2.1.17, enoyl-CoA hydratase and EC 4.2.1.74, long-chain-enoyl-CoA hydratase. Group: Enzymes. Synonyms: 3-hydroxybutyryl-CoA dehydratase; crotonase; crt (gene name). Enzyme Commission Number: EC 4.2.1.150. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4991; short-chain-enoyl-CoA hydratase; EC 4.2.1.150; 3-hydroxybutyryl-CoA dehydratase; crotonase; crt (gene name). Cat No: EXWM-4991. | |
| spheroidene monooxygenase | The enzyme is involved in spheroidenone biosynthesis and in 2,2'-dioxospirilloxanthin biosynthesis. The enzyme from Rhodobacter sphaeroides contains heme at its active site. Group: Enzymes. Synonyms: CrtA; acyclic carotenoid 2-ketolase; spirilloxanthin monooxygenase; 2-oxo-spirilloxanthin monooxygenase. Enzyme Commission Number: EC 1.14.15.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0952; spheroidene monooxygenase; EC 1.14.15.9; CrtA; acyclic carotenoid 2-ketolase; spirilloxanthin monooxygenase; 2-oxo-spirilloxanthin monooxygenase. Cat No: EXWM-0952. | |
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