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| Product | Description | |
|---|---|---|
| Cucurbitacin | Cucurbitacin. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2222-7-3. Molecular Formula: C30H42O7. Mole Weight: 514.66. Catalog: APB2222073. |  |
| Cucurbitacin A | Cucurbitacin A. Group: Biochemicals. CAS No. 6040-19-3. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Cucurbitacin A | Cucurbitacin A is a triterpenoid sterol isolated from rhizomes of Hemsleya amabilis Diels. Synonyms: Cucurbitacin A; 6040-19-3; UNII-83859; MTO77NSC94743; CHEBI:3940. Grades: >98%. CAS No. 6040-19-3. Molecular formula: C32H46O9. Mole weight: 574.711. |  |
| Cucurbitacin B | Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 6199-67-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0416. |  |
| Cucurbitacin B | Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids; could repress cancer cell progression.IC50 value:Target: anticancer natural compoundin vitro: Cucurbitacin-B inhibited growth and modulated expression of cell-cycle regulators in SHSY5Y cells. At the molecular level, we found that Cucurbitacin-B inhibited AKT signaling activation through up-regulation of PTEN. CuB induced apoptosis of A549 cells in a -concentration-dependent manner, as determined by fluorescence microscopy, flow cytometry and transmission electron microscopy. CuB dose-dependently inhibited lung cancer cell proliferation, with cell cycle inhibition and cyclin B1 downregulation. Apoptosis induced by CuB was shown to be associated with cytochrome c release, B-cell lymphoma 2 downregulation and signal transducer and activator of transcription 3 pathway inhibition. CuB inhibited ITGA6 and ITGB4 (integrin α6 and integrin β4), which are overexpressed in breast cancer. Furthermore, CuB also induced the expression of major ITGB1and ITGB3, which are known to cause integrin-mediated cell death. Cuc B treatment caused DNA double-strand breaks (DSBs) without affecting the signal transducer and activator of transcription 3 (STAT3), the potential molecular target for Cuc B. Cuc B triggers ATM-activated Chk1-Cdc25C-Cdk1, which could be reversed by both ATM siRNA and Chk1 siRNA. Cuc B also triggers ATM-activated p53-14-3-3-σ pa |  |
| Cucurbitacin B | Cucurbitacin B. Group: Biochemicals. Alternative Names: Amarin. Grades: Plant Grade. CAS No. 6199-67-3. Pack Sizes: 20mg. Molecular Formula: C32H46O8, Molecular Weight: 558.703. US Biological Life Sciences. | Worldwide |
| Cucurbitacin C | Cucurbitacin C is a cucurbitacin. Grades: > 95%. CAS No. 5988-76-1. Molecular formula: C32H48O8. Mole weight: 560.72. | |
| Cucurbitacin D | Cucurbitacin D. Group: Biochemicals. CAS No. 3877-86-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Cucurbitacin D | Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis , exhibiting anti-tumor and anti-inflammatory effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 3877-86-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1986. | |
| Cucurbitacin D | Cucurbitacin D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 3877-86-9. Molecular Formula: C30H44O7. Mole Weight: 516.68. Catalog: APB3877869. | |
| Cucurbitacin D | Source from rhizomes of Hemsleya amabilis Diels. It might be a new therapeutic option for the treatment of endometrial and ovarian cancers, also may be a potential therapeutic agent for β-hemoglobinopathies, including sickle cell anemia and β-thalassemia. And it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. Uses: Antitumor, resistance to chemical carcinogens, protect liver. Synonyms: 17-[(3E)-1,5-Dihydroxy-1,5-dimethyl-2-oxohex-3-en-1-yl]-2,16-dihydroxy-4,4,9,14-tetramethylestr-5-ene-3,11-dione. Grades: >98%. CAS No. 3877-86-9. Molecular formula: C30H44O7. Mole weight: 516.67. | |
| cucurbitacin Δ23-reductase | Requires Mn2+. Fe2+ or Zn2+ can replace Mn2+ to some extent. Group: Enzymes. Synonyms: NAD(P)H: cucurbitacin B Δ23-oxidoreductase. Enzyme Commission Number: EC 1.3.1.5. CAS No. 37256-38-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1322; cucurbitacin Δ23-reductase; EC 1.3.1.5; 37256-38-5; NAD(P)H: cucurbitacin B Δ23-oxidoreductase. Cat No: EXWM-1322. |  |
| Cucurbitacin E | Cucurbitacin E. Group: Biochemicals. Alternative Names: Cucurbitacine E; NSC 106399; NSC 521775; α-Elaterin; α-Elaterine; 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9 β,10α-lanosta-1,5,23-triene-3,11,22-trione 25-Acetate. Grades: Highly Purified. CAS No. 18444-66-1. Pack Sizes: 1mg. Molecular Formula: C32H44O8, Molecular Weight: 556.69. US Biological Life Sciences. | Worldwide |
| Cucurbitacin E | Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 18444-66-1. Molecular formula: C32H44O8. Mole weight: 556.67. Purity: 0.98. IUPACName: [(E,6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate. Canonical SMILES: CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3C=C(C(=O)C4(C)C)O)C)C)C)O)O. Product ID: ACM18444661. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cucurbitacin E 2-O-glucoside | Cucurbitacin E 2-O-glucoside. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1398-78-3. Molecular Formula: C38H54O13. Mole Weight: 718.84. Catalog: APB1398783. | |
| Cucurbitacin I | Cucurbitacin I. Group: Biochemicals. Grades: Purified. CAS No. 2222-7-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cucurbitacin I | Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cucurbitacin I. Product Category: Inhibitors. Appearance: White solid. CAS No. 2222-7-3. Molecular formula: C30H42O7. Mole weight: 514.65. Purity: 0.98. Density: 1.26g/cm³. Product ID: ACM2222073. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cucurbitacin I | Cucurbitacin I is a triterpenoid compound which is extracted from some Cucurbitaceae related plants. It was found to be a potential selective inhibitor of JAK2 / STAT3 showing various of possible Pharmacological activities.(IC50 = 500 nM when suppresses l. Uses: Cucurbitacin i is a triterpenoid compound and has been found to be a potential selective inhibitor of jak2 / stat3. Synonyms: Cucurbitacin I; Elatericin B; Cucurbitacine (I); 1,2-Dehydroelatericin A; CHEBI:3947. Grades: ≥95%. CAS No. 2222-7-3. Molecular formula: C30H42O7. Mole weight: 514.65. | |
| Cucurbitacin Iia | Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 58546-34-2. Molecular formula: C32H50O8. Mole weight: 562.73. Purity: 0.98. IUPACName: [(6R)-6-hydroxy-2-methyl-5-oxo-6-[(2S,3S,8S,9R,10R,13R,14S,16R,17R)-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]heptan-2-yl] acetate. Canonical SMILES: CC(=O)OC(C)(C)CCC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(C4(C)C)O)O)C)C)C)O)O. Product ID: ACM58546342. Alfa Chemistry ISO 9001:2015 Certified. Categories: Hemslecin A. | |
| Cucurbitacin IIa | Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin , reduces phospho-Histone H3 and increases cleaved PARP in cancer cells [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Hemslecin A. CAS No. 58546-34-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N1988. | |
| Cucurbitacin IIb | Cucurbitacin IIb. Group: Biochemicals. Alternative Names: 23,24-Dihydrocucurbitacin F. Grades: Plant Grade. CAS No. 50298-90-3. Pack Sizes: 10mg. Molecular Formula: C30H48O7, Molecular Weight: 520.698. US Biological Life Sciences. | Worldwide |
| Cucurbitacin impurity 1 | Cucurbitacin impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 17278-28-3. Molecular Formula: C32H46O8. Mole Weight: 558.71. Catalog: APB17278283. | |
| Cucurbitacin impurity 2 | Cucurbitacin impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 65247-27-0. Molecular Formula: C38H56O13. Mole Weight: 720.85. Catalog: APB65247270. | |
| Cucurbitacin impurity 3 | Cucurbitacin impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1110-02-7. Molecular Formula: C30H44O7. Mole Weight: 516.68. Catalog: APB1110027. | |
| Cucurbitacin Q1 | Cucurbitacin Q1 is a terpenoid isolated from hemsleya amabilis. Synonyms: 25-acetylcucurbitacin F; 25-O-Acetylcucurbitacin F. Grades: 0.98. CAS No. 99530-82-2. Molecular formula: C32H48O8. Mole weight: 560.7. | |
| Cucurbitacin S | Botanical Source: Group: Biochemicals. Grades: Plant Grade. CAS No. 60137-06-6. Pack Sizes: 10mg, 20mg. US Biological Life Sciences. | Worldwide |
| 2-O-b-D-Glucopyranosylcucurbitacin E | 2-O-b-D-Glucopyranosylcucurbitacin E, a naturally occurring compound extensively implemented within the biomedicine industry, is recognized for its remarkable potential in combatting several forms of cancer including breast, colon, and liver cancer. The compound has demonstrated a considerable ability to impede tumor growth by provoking apoptosis and obstructing essential cellular processes. Furthermore, the scientific community has recently commenced researching the prospective application of this compound as an anti-inflammatory agent, as well as a method of decreasing blood glucose levels in patients with diabetes. Synonyms: (9β,10α,16α,23E)-25-(Acetyloxy)-2-(β-D-glucopyranosyloxy)-16,20-dihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione Coloside A Cucurbitacin E 2-O-b-D-glucopyranoside Gratiotoxin. CAS No. 1398-78-3. Molecular formula: C38H54O13. Mole weight: 718.83. | |
| Hemslecin A (Cucurbitacin IIa) | Hemslecin A (Cucurbitacin IIa). Group: Biochemicals. Alternative Names: Cucurbitacin IIa. Grades: Plant Grade. CAS No. 58546-34-2. Pack Sizes: 20mg. Molecular Formula: C32H50O8, Molecular Weight: 562.735. US Biological Life Sciences. | Worldwide |
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