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| Product | Description | |
|---|---|---|
| Cucurbitacin B | Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 6199-67-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0416. |  |
| Cucurbitacin B | Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids; could repress cancer cell progression.IC50 value:Target: anticancer natural compoundin vitro: Cucurbitacin-B inhibited growth and modulated expression of cell-cycle regulators in SHSY5Y cells. At the molecular level, we found that Cucurbitacin-B inhibited AKT signaling activation through up-regulation of PTEN. CuB induced apoptosis of A549 cells in a -concentration-dependent manner, as determined by fluorescence microscopy, flow cytometry and transmission electron microscopy. CuB dose-dependently inhibited lung cancer cell proliferation, with cell cycle inhibition and cyclin B1 downregulation. Apoptosis induced by CuB was shown to be associated with cytochrome c release, B-cell lymphoma 2 downregulation and signal transducer and activator of transcription 3 pathway inhibition. CuB inhibited ITGA6 and ITGB4 (integrin α6 and integrin β4), which are overexpressed in breast cancer. Furthermore, CuB also induced the expression of major ITGB1and ITGB3, which are known to cause integrin-mediated cell death. Cuc B treatment caused DNA double-strand breaks (DSBs) without affecting the signal transducer and activator of transcription 3 (STAT3), the potential molecular target for Cuc B. Cuc B triggers ATM-activated Chk1-Cdc25C-Cdk1, which could be reversed by both ATM siRNA and Chk1 siRNA. Cuc B also triggers ATM-activated p53-14-3-3-σ pa |  |
| Cucurbitacin B | Cucurbitacin B. Group: Biochemicals. Alternative Names: Amarin. Grades: Plant Grade. CAS No. 6199-67-3. Pack Sizes: 20mg. Molecular Formula: C32H46O8, Molecular Weight: 558.703. US Biological Life Sciences. |  Worldwide |
| Cucurbitacin B hydrate | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Cucurbitacin A | Cucurbitacin A. Group: Biochemicals. CAS No. 6040-19-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Cucurbitacin A | Cucurbitacin A is a triterpenoid sterol isolated from rhizomes of Hemsleya amabilis Diels. Synonyms: Cucurbitacin A; 6040-19-3; UNII-83859; MTO77NSC94743; CHEBI:3940. Grade: >98%. CAS No. 6040-19-3. Molecular formula: C32H46O9. Mole weight: 574.711. |  |
| Cucurbitacin D | Cucurbitacin D. Group: Biochemicals. CAS No. 3877-86-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| cucurbitacin Δ23-reductase | Requires Mn2+. Fe2+ or Zn2+ can replace Mn2+ to some extent. Group: Enzymes. Synonyms: NAD(P)H: cucurbitacin B Δ23-oxidoreductase. Enzyme Commission Number: EC 1.3.1.5. CAS No. 37256-38-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1322; cucurbitacin Δ23-reductase; EC 1.3.1.5; 37256-38-5; NAD(P)H: cucurbitacin B Δ23-oxidoreductase. Cat No: EXWM-1322. |  |
| Cucurbitacin E | Cucurbitacin E. Group: Biochemicals. Alternative Names: Cucurbitacine E; NSC 106399; NSC 521775; α-Elaterin; α-Elaterine; 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9 β,10α-lanosta-1,5,23-triene-3,11,22-trione 25-Acetate. Grades: Highly Purified. CAS No. 18444-66-1. Pack Sizes: 1mg. Molecular Formula: C32H44O8, Molecular Weight: 556.69. US Biological Life Sciences. | Worldwide |
| Cucurbitacin E | Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 18444-66-1. Molecular formula: C32H44O8. Mole weight: 556.67. Purity: 0.98. IUPACName: [(E,6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate. Canonical SMILES: CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3C=C(C(=O)C4(C)C)O)C)C)C)O)O. Product ID: ACM18444661. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cucurbitacin I | Cucurbitacin I. Group: Biochemicals. Grades: Purified. CAS No. 2222-7-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cucurbitacin I | Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity. Uses: Scientific research. Group: Natural products. Alternative Names: Elatericin B; JSI-124; NSC-521777. CAS No. 2222-7-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1405. | |
| Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 | A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. Group: Fluorescence/luminescence spectroscopy. | |
| Cucurbitacin IIb | Cucurbitacin IIb. Group: Biochemicals. Alternative Names: 23,24-Dihydrocucurbitacin F. Grades: Plant Grade. CAS No. 50298-90-3. Pack Sizes: 10mg. Molecular Formula: C30H48O7, Molecular Weight: 520.698. US Biological Life Sciences. | Worldwide |
| Cucurbitacin S | Botanical Source: Group: Biochemicals. Grades: Plant Grade. CAS No. 60137-06-6. Pack Sizes: 10mg, 20mg. US Biological Life Sciences. | Worldwide |
| Dihydrocucurbitacin F | Cucurbitacin IIb (CuIIb) is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. Synonyms: Cucurbitacin Iib; 23,24-Dihydrocucurbitacin F. Grade: >98%. CAS No. 50298-90-3. Molecular formula: C30H48O7. Mole weight: 520.7. | |
| Hemslecin A (Cucurbitacin IIa) | Hemslecin A (Cucurbitacin IIa). Group: Biochemicals. Alternative Names: Cucurbitacin IIa. Grades: Plant Grade. CAS No. 58546-34-2. Pack Sizes: 20mg. Molecular Formula: C32H50O8, Molecular Weight: 562.735. US Biological Life Sciences. | Worldwide |
| Momordicoside K | Momordicoside K is a cucurbitacin found in Momordica charantia (bitter melon). Synonyms: 19-Norlanosta-5,23-diene-9-carboxaldehyde, 7-(β-D-glucopyranosyloxy)-3-hydroxy-25-methoxy-, (3β,7β,9β,10α,23E)-; (1S,4R,7S,9β,23E)-9-Formyl-1-hydroxy-25-methoxy-10,14-dimethyl-4,9-cyclo-9,10-secocholesta-5,23-dien-7-yl β-D-glucopyranoside. Grade: ≥95%. CAS No. 81348-84-7. Molecular formula: C37H60O9. Mole weight: 648.88. | |
| Momordicoside L | Momordicoside L is a cucurbitacin found in Momordica charantia (bitter melon). Synonyms: 19-Norlanosta-5,23-diene-9-carboxaldehyde, 7-(β-D-glucopyranosyloxy)-3,25-dihydroxy-, (3β,7β,9β,10α,23E)-; (1S,4R,7S,9β,23E)-9-Formyl-1,25-dihydroxy-10,14-dimethyl-4,9-cyclo-9,10-secocholesta-5,23-dien-7-yl β-D-glucopyranoside; (3β,7β,9β,10α,17β)-7-(β-D-glucopyranosyloxy)-3-hydroxy-17-[(3E)-5-hydroxy-1,5-dimethylhex-3-en-1-yl]-4,4,14-trimethylestr-5-ene-9-carboxaldehyde. Grade: ≥95%. CAS No. 81348-83-6. Molecular formula: C36H58O9. Mole weight: 634.85. | |
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