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| Product | Description | |
|---|---|---|
| CUDC-907 | CUDC-907 is a dual PI3K and HDAC inhibitor. Studies have shown CUDC-907 is able to enhance antitumor activity when combined with standard of care agents in multiple myeloma and B cell lymphoma xenograft models. Group: Biochemicals. Alternative Names: N-Hydroxy-2-[[[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]methylamino]-5-pyrimidinecarboxamide; N-Hydroxy-2-[[[2- (6-methoxypyridin-3-yl) -4- (morpholin-4-yl) thieno[3, 2-d]pyrimidin-6-yl]methyl] (methyl) amino]pyrimidine-5-carboxamide. Grades: Highly Purified. CAS No. 1339928-25-4. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| CUDC-907 | CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. Synonyms: CUDC907; CUDC 907; CUDC-907. CAS No. 1339928-25-4. Molecular formula: C23H24N8O4S. Mole weight: 508.557. |  |
| CUDC-907-d3 | CUDC-907-d3. Group: Biochemicals. Alternative Names: N-Hydroxy-2-[[[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]methylamino]-5-pyrimidinecarboxamide-d3; N-Hydroxy-2-[[[2- (6-methoxypyridin-3-yl) -4- (morpholin-4-yl) thieno[3, 2-d]pyrimidin-6-yl]methyl] (methyl) amino]pyrimidine-5-carboxamide-d3. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C23H21D3N8O4S, Molecular Weight: 511.57. US Biological Life Sciences. | Worldwide |
| Fimepinostat | Fimepinostat (CUDC-907) potently inhibits class I PI3K s as well as classes I and II HDAC enzymes with an IC 50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CUDC-907. CAS No. 1339928-25-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13522. |  |
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