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| Product | Description | |
|---|---|---|
| Cuspin-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Cuspin-1 | Cuspin-1 is an upregulator of the Survival of Motor Neuron protein (SMN; EC50 value 18 μM in SMA patient fibroblast cells). Increased phosphorylation of ERK initiates Ras-Raf-MEK signaling, upregulating SMN protein levels in spinal muscular atrophy (SMA) patient fibroblasts. Synonyms: 3-bromo-5-(4-methylbenzoyl)pyridine; (5-bromopyridin-3-yl)-(4-methylphenyl)methanone. Grades: 99%. CAS No. 337932-29-3. Molecular formula: C13H10BrNO. Mole weight: 276.13. |  |
| Cuspin-1 ( (5-Bromo-3-pyridinyl) (4-methylphenyl) methanone, Survival Motor Neuron Protein Upregulator, Cuspin-1) | A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48h; 5ug/ml), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (tmax = 24h; 10ug/ml), indicative of Ras-Raf-MEK signaling pathway activation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??BrNO. US Biological Life Sciences. |  Worldwide |
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