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| Product | Description | |
|---|---|---|
| CX-5461 | CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. Synonyms: CX-5461; CX 5461; CX5461. CAS No. 1138549-36-6. Molecular formula: C27H27N7O2S. Mole weight: 513.62. |  |
| CX-5461 | CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1138549-36-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13323. |  |
| CX-5461 dihydrochloride | CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ?25 ?M). Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13323A. | |
| CX-5461 dihydrochloride | CX-5461 dihydrochloride is a potent and orally bioavailable Pol I-mediated rRNA synthesis inhibitor, with IC50s of 142, 113 and 54 nM in HCT-116, A375 and MIA PaCa-2 cells, respectively. It shows little or no effect on Pol II (IC50 ≥25 μM). Synonyms: 5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-, hydrochloride (1:2). Grade: ≥98%. Molecular formula: C27H29Cl2N7O2S. Mole weight: 586.54. | |
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