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| Product | Description | |
|---|---|---|
| CYC116 | CYC116 is an orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine/threonine protein kinases that are only expressed in actively dividing cells and are critical in division or mitosis. VEGFR2 is a receptor tyrosine kinase that appears to account for most of the mitogenic and chemotactic effects of vascular endothelial growth factor (VEGF) on adult endothelial cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CYC116; CYC 116; CYC-116. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 693228-63-6. Molecular formula: C18H20N6OS. Mole weight: 368.46. Purity: >98%. IUPACName: 4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine. Canonical SMILES: NC1=NC(C)=C(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)S1. Product ID: ACM693228636. Alfa Chemistry ISO 9001:2015 Certified. Categories: CFC-116. |  |
| CYC116 | CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1. Synonyms: CYC116; CYC 116; CYC-116. CAS No. 693228-63-6. Molecular formula: C18H20N6OS. Mole weight: 368.46. |  |
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