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| Product | Description | |
|---|---|---|
| 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase | This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. Group: Enzymes. Synonyms: diphosphopyridine nucleosidase (ambiguous); CD38 (gene name); BST1 (gene name). Enzyme Commission Number: EC 2.4.99.20. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2705; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; EC 2.4.99.20; diphosphopyridine nucleosidase (ambiguous); CD38 (gene name); BST1 (gene name). Cat No: EXWM-2705. |  |
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | This multiunctional enzyme catalyses both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. cf. EC 3.2.2.5, NAD+ glycohydrolase. Group: Enzymes. Synonyms: NAD+ nucleosidase; NADase (ambiguous); DPNase (ambiguous); DPN hydrolase (ambiguous); NAD hydrolase (ambiguous); nicotinamide adenine dinucleotide nucleosidase (ambiguous); NAD glycohydrolase (misleading); NAD nucleosidase (ambiguous); nicotinamide adenine dinucleotide glycohydrolase (misleading); CD38 (. Enzyme Commission Number: EC 3.2.2.6. CAS No. 9032-65-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3988; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; EC 3.2.2.6; 9032-65-9; NAD+ nucleosidase; NADase (ambiguous); DPNase (ambiguous); DPN hydrolase (ambiguous); NAD hydrolase (ambiguous); nicotinamide adenine dinucleotide nucleosidase (ambiguous); NAD glycohydrolase (misleading); NAD nucleosidase (ambiguous); nicotinamide adenine dinucleotide glycohydrolase (misleading); CD38 (gene name); BST1 (gene name). Cat No: EXWM-3988. | |
| Adenosine5'-(trihydrogen diphosphate),1-b-D-ribofuranosyl-,intramol. p',5''-ester | Adenosine5'-(trihydrogen diphosphate),1-b-D-ribofuranosyl-,intramol. p',5''-ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: cyclic adenosine 5-diphosphoribose; Cyclic Adenosine Diphosphate Ribose; cADP-Ribose; Cyclic ADPR; cyclic ADP-D-ribose; E-NAD; Enzyme-activated NAD; cyclic adenosine 5-diphosphate ribose; cADPR; adenosine 5-cyclic-diphosphoribose. Product Category: Heterocyclic Organic Compound. Appearance: Lyophilized powder. CAS No. 119340-53-3. Molecular formula: C15H21N5O13P2. Mole weight: 541.3005. Purity: >94%. IUPACName: cyclic ADP-ribose. Density: 2.57 g/cm³. Product ID: ACM119340533. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ADP-ribose 1''-phosphate phosphatase | The enzyme is highly specific for ADP-D-ribose 1''-phosphate. Involved together with EC 3.1.4.37, 2',3'-cyclic-nucleotide 3'-phosphodiesterase, in the breakdown of adenosine diphosphate ribose 1'',2''-cyclic phosphate (Appr>p), a by-product of tRNA splicing. Group: Enzymes. Synonyms: POA1; Appr1p phosphatase; Poa1p; ADP-ribose 1''-phosphate phosphohydrolase. Enzyme Commission Number: EC 3.1.3.84. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3690; ADP-ribose 1''-phosphate phosphatase; EC 3.1.3.84; POA1; Appr1p phosphatase; Poa1p; ADP-ribose 1''-phosphate phosphohydrolase. Cat No: EXWM-3690. | |
| cADP-Ribose (cADPR) Ammonium Salt | Cyclic ADP-ribose ammonium is a potent calcium-mobilized second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and extracellular influx through the opening of TRPM2 channels. Synonyms: cADP-Ribose Ammonium Salt; cADPR Ammonium Salt; cyclic ADP-ribose ammonium salt; Cyclic Adenosine Diphosphate Ribose ammonium salt; Cyclic adenosine 5'-diphosphate ribose ammonium salt. Grade: 90%. Molecular formula: C15H21N5O13P2.x(NH3). Mole weight: 541.30 (free base). |  |
| Cyclic ADP-?ribose | Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor -mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: cADPR. CAS No. 119340-53-3. Pack Sizes: 500 μg. Product ID: HY-N7395. |  |
| Cyclic ADP-?ribose | Cyclic ADP-ribose is a potent calcium-mobilized second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and extracellular influx through the opening of TRPM2 channels. Synonyms: cADPR; Adenosine 5'-(trihydrogen diphosphate), 1-b-D-ribofuranosyl-, intramol, P',5''-ester; (2R,3R,4S,5R,13R,14S,15R,16R)-24-Imino-7,9,11,25,26-pentaoxa-1,17,19,22-tetraaza-8,10-diphosphapentacyclo[18.3.1.12,5.113,16.017,21]hexacosa-18,20,22-triene-3,4,8,10,14,15-hexol 8,10-dioxide; Cyclic adenosine 5'-diphosphate ribose; Cyclic adenosine diphosphate-ribose; Cyclic ADP-ribose. Grade: >94%. CAS No. 119340-53-3. Molecular formula: C15H21N5O13P2. Mole weight: 541.30. | |
| NADH disodium salt | NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, ?-oxidation and the tricarboxylic acid (TCA) cycle[1]. Uses: Scientific research. Group: Natural products. Alternative Names: Disodium NADH. CAS No. 606-68-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-F0001. | |
| Sulfo-ara-F-NMN | Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 ?M). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CZ-48. CAS No. 1374663-29-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129522. | |
| 2'-phosphotransferase | Catalyses the final step of tRNA splicing in the yeast Saccharomyces cerevisiae. The reaction takes place in two steps: in the first step, the 2'-phosphate on the RNA substrate is ADP-ribosylated, causing the relase of nicotinamide and the formation of the reaction intermediate, ADP-ribosylated tRNA. In the second step, dephosphorylated (mature) tRNA is formed along with ADP ribose 1''-2''-cyclic phosphate. Highly specific for oligonucleotide substrates bearing an internal 2'-phosphate. Oligonucleotides with only a terminal 5'- or 3'-phosphate are not substrates. Group: Enzymes. Synonyms: yeast 2'-phosphotransferase; Tpt1; Tpt1p; 2'-phospho-tRNA:NAD+ phosphotransferase. Enzyme Commission Number: EC 2.7.1.160. CAS No. 126905-00-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2990; 2'-phosphotransferase; EC 2.7.1.160; 126905-00-8; yeast 2'-phosphotransferase; Tpt1; Tpt1p; 2'-phospho-tRNA:NAD+ phosphotransferase. Cat No: EXWM-2990. | |
| adenylate cyclase | Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+-arginine ADP-ribosyltransferase. Group: Enzymes. Synonyms: adenylylcyclase; adenyl cyclase; 3',5'-cyclic AMP synthetase; ATP diphosphate-lyase (cyclizing). Enzyme Commission Number: EC 4.6.1.1. CAS No. 9012-42-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5348; adenylate cyclase; EC 4.6.1.1; 9012-42-4; adenylylcyclase; adenyl cyclase; 3',5'-cyclic AMP synthetase; ATP diphosphate-lyase (cyclizing). Cat No: EXWM-5348. | |
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