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| Product | Description | |
|---|---|---|
| Cyclic GMP | Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 7665-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113469. |  |
| cyclic GMP-AMP synthase | Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines. Group: Enzymes. Synonyms: cGAMP synthase; cGAS. Enzyme Commission Number: EC 2.7.7.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3299; cyclic GMP-AMP synthase; EC 2.7.7.86; cGAMP synthase; cGAS. Cat No: EXWM-3299. |  |
| Cyclic GMP sodium | Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 40732-48-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113469A. | |
| Cyclic GMP sodium salt | Cyclic GMP or cGMP is a second messenger and it is biosynthesized from GTP by guanylate cyclases. Nitric oxide and natriuretic peptides arw activators of guanylate cyclases. cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis. Synonyms: cGMP; Cyclic guanosine monophosphate; Guanosine 3'5'-cyclic monophosphate; Monosodium-GMP. Grades: ≥98%. CAS No. 40732-48-7. Molecular formula: C10H11N5O7P·Na. Mole weight: 367.2. |  |
| 3',5'-cyclic-GMP phosphodiesterase | This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. Group: Enzymes. Synonyms: guanosine cyclic 3',5'-phosphate phosphodiesterase; cyclic GMP phosphodiesterase; cyclic 3',5'-GMP phosphodiesterase; cyclic guanosine 3',5'-monophosphate phosphodiesterase; cyclic guanosine 3',5'-phosphate phosphodiesterase; cGMP phosphodiesterase; cGMP-PDE. Enzyme Commission Number: EC 3.1.4.35. CAS No. 9068-52-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3719; 3',5'-cyclic-GMP phosphodiesterase; EC 3.1.4.35; 9068-52-4; guanosine cyclic 3',5'-phosphate phosphodiesterase; cyclic GMP phosphodiesterase; cyclic 3',5'-GMP phosphodiesterase; cyclic guanosine 3',5'-monophosphate phosphodiesterase; cyclic guanosine 3',5'-phosphate phosphodiesterase; cGMP phosphodiesterase; cGMP-PDE. Cat No: EXWM-3719. | |
| Cyclic di-GMP sodium salt | Cyclic di-GMP is a second messenger in bacteria, which is involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. Cyclic di-GMP induces expression of IFN-β mRNA in vitro (EC50 = 537.8 nM) but less potently than 2'3'-cGAMP, 3'2'-cGAMP, 3'3'-cGAMP, and 2'2'-cGAMP. Synonyms: c-di-GMP; Cyclic diguanylate; 3',5'-Cyclic diguanylic acid. Grades: ≥95%. CAS No. 2222132-40-1. Molecular formula: C20H22N10Na2O14P2. Mole weight: 734.37. | |
| Rp-8-bromo-Cyclic GMPS sodium salt | Rp-8-bromo-Cyclic GMPS is a cell-permeable analog of cGMP and an inhibitor of cGMP-dependent protein kinase (cGK). Synonyms: 8-bromo-guanosinecyclic3',5'-[(R)-(hydrogenphosphorothioate)], monosodium salt; Rp-8-Br-cGMPS; Rp-8-bromo-cGMPS. Grades: ≥99%. CAS No. 208445-06-1. Molecular formula: C10H10BrN5O6PS·Na. Mole weight: 462.1. | |
| Rp-8-bromo-PET-Cyclic GMPS sodium salt | Rp-8-bromo-PET-Cyclic GMPS is an analog of cyclic GMP (cGMP) and an inhibitor of cGMP-dependent protein kinases (cGKs). Synonyms: Rp-8-Br-PET-cGMPS; Rp-8-bromo-PET-cGMPS. Grades: ≥99%. CAS No. 185246-32-6. Molecular formula: C18H14BrN5O6PS·Na. Mole weight: 562.27. | |
| 2',3'-cGAMP | 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-3'-cyclic GMP-AMP. CAS No. 1441190-66-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100564. | |
| 2',3'-cGAMP sodium | 2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-3'-cyclic GMP-AMP sodium. CAS No. 2734858-36-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-100564A. | |
| 2',3'-cGAMP sodium salt | 2',3'-cGAMP sodium is an endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-&beta. 2',3'-cGAMP is an effective adjuvant that boosts the production of antigen-specific antibodies and T cell responses in mice. Synonyms: Cyclic [G(2',5')pA(3',5')p] sodium; cyclic GMP-AMP sodium; 2',3'-cyclic GMP-AMP sodium; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt. Grades: 95%. CAS No. 2734858-36-5. Molecular formula: C20H22N10Na2O13P2. Mole weight: 718.38. | |
| 2'-GMP | 2'-GMP is a metabolite of guanosine-2',3'-cyclic monophosphate. Synonyms: Guanosine- 2'- O- monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 130-50-7. Molecular formula: C10H14N5O8P (free acid). Mole weight: 363.2 (free acid). | |
| 3',5'-cyclic-AMP phosphodiesterase | Requires Mg2+ or Mn2+ for activity. This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. Group: Enzymes. Synonyms: cAMP-specific phosphodiesterase; cAMP-specific PDE; PDE1; PDE2A; PDE2B; PDE4; PDE7; PDE8; PDEB1; PDEB2. Enzyme Commission Number: EC 3.1.4.53. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3736; 3',5'-cyclic-AMP phosphodiesterase; EC 3.1.4.53; cAMP-specific phosphodiesterase; cAMP-specific PDE; PDE1; PDE2A; PDE2B; PDE4; PDE7; PDE8; PDEB1; PDEB2. Cat No: EXWM-3736. | |
| 3',5'-cyclic-nucleotide phosphodiesterase | Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP. Group: Enzymes. Synonyms: cyclic 3',5'-mononucleotide phosphodiesterase; PDE; cyclic 3',5'-nucleotide phosphodiesterase; cyclic 3',5'-phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; 3',5'-cyclonucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase; 3', 5'-cyclic nucleoside monophosphate p. Enzyme Commission Number: EC 3.1.4.17. CAS No. 9040-59-9. PDE. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3716; 3',5'-cyclic-nucleotide phosphodiesterase; EC 3.1.4.17; 9040-59-9; cyclic 3',5'-mononucleotide phosphodiesterase; PDE; cyclic 3',5'-nucleotide phosphodiesterase; cyclic 3',5'-phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; 3',5'-cyclonucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase; 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP); cyclic 3',5-nucleotide monophosphate phosphodiesterase; nucleoside 3',5'-cyclic phosphate diesterase; nucleoside-3',5-monophosphate phosphodiesterase. Cat No: EXWM-3716. | |
| 3'-GMP | 3'-GMP is a metabolite of guanosine-2',3'-cyclic monophosphate. Synonyms: Guanosine- 3'- O- monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 6027-83-4. Molecular formula: C10H14N5O8P (free acid). Mole weight: 363.2 (free acid). | |
| 3-Methylxanthine | 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC 50 of 920 μM on guinea-pig isolated trachealis muscle. Uses: Scientific research. Group: Natural products. CAS No. 1076-22-8. Pack Sizes: 10 mM * 1 mL; 5 g; 25 g; 50 g. Product ID: HY-50723. | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-655 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-655, a fluorescent probe that selectively interacts with cyclic GMP, offers a unique opportunity to gain insights into the spatiotemporal regulation of this crucial second messenger in living cells. By illuminating the intricacies of cyclic GMP signaling, this probe promises to unlock the secrets of a wide range of diseases, from cardiovascular disorders to cancer. Witness the power of precision science with this cutting-edge technology. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 655, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 655 (free acid). Mole weight: 968.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-665 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-665 is a fluorescent-labeled nucleotide used in biomedicine to study guanosine cyclic monophosphate (cGMP)-related signaling pathways. It has been used in studies looking at nitric oxide (NO) signaling and the cyclic GMP-protein kinase G (PKG) pathway, which are involved in regulating smooth muscle relaxation. Additionally, it has potential therapeutic applications in treating cardiovascular diseases and pulmonary hypertension. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 665. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 665 (free acid). Mole weight: 1063.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GMP - 5/6-TAMRA | 8-[(6-Amino)hexyl]-amino-GMP - 5/6-TAMRA is an esteemed fluorescent probe which specializes in the detection and analysis of cell signaling pathways related to G proteins and cyclic nucleotides. Deployed across a range of biomedical industries for research on cancer, cardiovascular diseases, and neurological disorders, this fantastic product is the ideal instrument for unraveling the mysteries of cellular communication. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-monophosphate, labeled with 5/6-TAMRA. Grades: ≥ 95% by HPLC. Molecular formula: C41H48N9O16P (free acid). Mole weight: 889.85 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GMP - ATTO-550 | ATTO-550 - 8-[(6-Amino)hexyl]-amino-GMP is a highly sophisticated fluorescent probe that has been meticulously engineered to gauge cyclic GMP levels in the body. Its immense versatility and potency render it as indispensable in research for assessing G-protein coupled receptors. ATTO-550 - 8-[(6-Amino)hexyl]-amino-GMP is further utilized as a tracer in immunohistochemistry. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-monophosphate, labeled with ATTO 550, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H28N7O8P - ATTO 550 (free acid). Mole weight: 1052.41 (free acid). | |
| 8-Methoxymethyl-1-methyl-3-(2-methylpropyl) Xanthine (8-Methoxymethyl-IBMX) | A specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase. Group: Biochemicals. Alternative Names: 8-Methoxymethyl-IBMX. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| 8-pCPT-PET-cGMP | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
| c-Di-GMP | c-diGMP is a bacterial second messenger and a STING ligand. Synonyms: 3'-Guanylic acid, guanylyl-(3'?5')-, cyclic nucleotide; 5GP-5GP; Cyclic di-3',5'-guanylate; Cyclic diguanylate; Cyclic diguanylate monophosphate; Cyclic-di-GMP. Grades: ≥95%. CAS No. 61093-23-0. Molecular formula: C20H24N10O14P2. Mole weight: 690.41. | |
| cGAMP | cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cyclic GMP-AMP; 3',3'-cGAMP. CAS No. 849214-04-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12512. | |
| cGAS-IN-2 | cGAS-IN-2 (compound 109) is a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), with IC 50 of 0.01512 μM for h-cGAS [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765273-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160546. | |
| cGMP-dependent protein kinase | CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase. Group: Enzymes. Synonyms: 3':5'-cyclic GMP-dependent protein kinase; cGMP-dependent protein kinase Iβ; guanosine 3':5'-cyclic monophosphate-dependent protein kinase; PKG; PKG 1α; PKG 1β; PKG II; STK23. Enzyme Commission Number: EC 2.7.11.12. CAS No. 141588-27-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3131; cGMP-dependent protein kinase; EC 2.7.11.12; 141588-27-4; 3':5'-cyclic GMP-dependent protein kinase; cGMP-dependent protein kinase Iβ; guanosine 3':5'-cyclic monophosphate-dependent protein kinase; PKG; PKG 1α; PKG 1β; PKG II; STK23. Cat No: EXWM-3131. | |
| CP 461 | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP 461; CP-461; CP461; OSI 461; UNII-68OJX9I7DT. N-benzyl-2-[6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide;hydrochloride; CAS: 227619-92-3 (CP-461 free base). Grades: >98%. CAS No. 227619-96-7. Molecular formula: C25H22ClFN2O. Mole weight: 420.91. | |
| CP-461 free base | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP-461 free base; CP 461 free base; CP461 free base; N-benzyl-2-[(3Z)-6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide; UNII-824ZMS3BGL; OSI-461 free base. Grades: >98%. CAS No. 227619-92-3. Molecular formula: C25H21FN2O. Mole weight: 384.45. | |
| Cyclic diguanosine monophosphate | Cyclic diguanosine monophosphate. Group: Biochemicals. Alternative Names: C-di-GMP; Cyclic-di-GMP; Cyclic bis (3',5') diguanylic acid; Cyclic diguanylate. Grades: Highly Purified. CAS No. 61093-23-0. Pack Sizes: 1mg, 2mg, 5mg. Molecular Formula: C20H24N10O14P2. US Biological Life Sciences. | Worldwide |
| cyclic-guanylate-specific phosphodiesterase | Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3,5-guanylate, the product of EC 2.7.7.65, diguanylate cyclase and an allosteric activator of EC 2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive. It is the balance between these two enzymes that determines the cellular level of c-di-GMP. Group: Enzymes. Synonyms: cyclic bis(3?5')diguanylate phosphodiesterase; c-di-GMP-specific phosphodiesterase; c-di-GMP phosphodiesterase; phosphodiesterase (misleading); phosphodiesterase A1; PDEA1; VieA. Enzyme Commission Number: EC 3.1.4.52. CAS No. 338732-46-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3735; cyclic-guanylate-specific phosphodiesterase; EC 3.1.4.52; 338732-46-0; cyclic bis(3?5')diguanylate phosphodiesterase; c-di-GMP-specific phosphodiesterase; c-di-GMP phosphodiesterase; phosphodiesterase (misleading); phosphodiesterase A1; PDEA1; VieA. Cat No: EXWM-3735. | |
| D(+)-Raffinose pentahydrate | D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA ( K d = 32 μM) and GtfC. D(+)-Raffinose pentahydrate reduces cyclic diguanylate (c-di-GMP) by increased activity of a c-di-GMP specific phosphodiesterase. D(+)-Raffinose pentahydrate interferes with GTF function. D(+)-Raffinose pentahydrate decreases IL-4 and IL-5 mRNA. D(+)-Raffinose pentahydrate exhibits biofilm-inhibitory activity against Pseudomonas aeruginosa and Streptococcus mutans and inhibits allergic airway eosinophilia [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: D-Raffinose pentahydrate. CAS No. 17629-30-0. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-N1938. | |
| G150 | G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC 50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2369751-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128583. | |
| Guanosine 3,5-Cyclic-13C,15N2 Monophosphate | Labeled Guanosine 3,5-Cyclic Monophosphate. Guanosine 3,5-Cyclic Monophosphate is a substituted Guanosine having cyclic phosphodiesterase activity. Group: Biochemicals. Alternative Names: Guanosine Cyclic-13C,15N2 3,5-(Hydrogen phosphate); Cyclic 3,5-Guanosine-13C,15N2 Monophosphate; Guanosine-13C,15N2 Monophosphate; GMP-13C,15N2. Grades: Highly Purified. CAS No. 40732-48-7-unlabeled. Pack Sizes: 500ug. Molecular Formula: C?¹³CH??N?¹?N?O?P, Molecular Weight: 348.18. US Biological Life Sciences. | Worldwide |
| Guanosine 3',5'-cyclic monophosphate | Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'-and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. 3',5'-cyclic GMP is a 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine. It has a role as a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a guanyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic GMP(1-). Synonyms: D-Guanosine 3',5'-cyclic monophosphate; 3',5'-cyclic GMP; 2-Amino-6-oxo-6,9-dihydro-1H-purine 3-oxide; guanine-3-N-oxide; 2-Amino-1,7-dihydro-6H-purin-6-one 3-oxide; Cyclic guanosine monophosphate; 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-1H-purin-6-one. Grades: ≥ 95%. CAS No. 7665-99-8. Molecular formula: C10H12N5O7P. Mole weight: 345.21. | |
| Guanosine 3:5-cyclic monophosphate sodium salt | Guanosine 3:5-cyclic monophosphate sodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: guanosine-3',5'-cyclicmonophosphate(cgmp),sodiumsalt;CGMP SODIUM SALT;CGMP NA;CYCLIC GMP SODIUM SALT;GUANOSINE 3,5-CYCLOPHOSPHATE MONOSODIUM SALT;GUANOSINE 3,5-MONOPHOSPHATE MONOSODIUM SALT;GUANOSINE 3:5-CYCLIC MONOPHOSPHATE SODIUM SALT;GUANOSINE-3,5-CYCLIC MONOPHOSPHATE SODIUM SALT. Appearance: powder. CAS No. 40732-48-7. Molecular formula: C10H11N5NaO7P. Mole weight: 367.19. Purity: 0.99. IUPACName: Guanosine 3,5-Cyclic Monophosphate Sodium Salt. Product ID: ACM40732487. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Guanosine 3',5'-cyclic monophosphate sodium salt | Guanosine 3',5'-cyclic monophosphate sodium salt. Group: Biochemicals. Alternative Names: cyclic GMP. Grades: Highly Purified. CAS No. 40732-48-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C10H11N5NaO7P. US Biological Life Sciences. | Worldwide |
| Guanylyl-3'-5'-adenosine triethylammonium salt | Guanylyl-3'-5'-adenosine triethylammonium salt is a versatile biomedical compound employed extensively within the pharmaceutical sector, emerging as a pivotal substrate for the esteemed guanylyl cyclase enzymes. This quintessential compound finds widespread utilization in an array of fundamental biochemical and pharmacological investigations, encompassing the study of cyclic GMP signaling cascade, neuropeptide release and the inducement of smooth muscle relaxation. Synonyms: GpA. Molecular formula: C20H25N10O11P·xC6H15N. Mole weight: 612.45 (free acid). | |
| Guanylyl-(3'-5')-guanosine | Guanylyl-(3'-5')-guanosine is a highly significant compound extensively employed in biomedical research, emerging as an indispensable player in signal transduction. Its pivotal role lies in its capacity to function as a second messenger molecule, especially in the modulation of cyclic GMP levels. Diverse cellular phenomena, encompassing vasodilation, neurotransmission and immune responses is are meticulously investigated utilizing this molecule to scrutinize the cGMP-dependent pathways. Synonyms: GpG RNA Dinucleotide (5'-3'). Grades: ≥95% by AX-HPLC. CAS No. 3353-33-1. Molecular formula: C20H25N10O12P. Mole weight: 628.40. | |
| HA-1004 | HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium , that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 91742-10-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-123468. | |
| MMPX | MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC50 = 5.2 μM). It causes an increase in cGMP but not cAMP, prolonging signal transduction for cGMP-dependent pathways. Synonyms: 8-Methoxymethyl-3-isobutyl-1-methylxanthine; MMPX; 8-METHOXYMETHYL-1-METHYL-3-(2-METHYLPROPYL)XANTHINE; 8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE; 8-METHOXYMETHYL-3-ISOBUTYRYL-1-METHYLXANTHINE; 8-METHOXYMETHYL-IBMX. CAS No. 78033-08-6. Molecular formula: C12H18N4O3. Mole weight: 266.3. | |
| MY-5445 | MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. Synonyms: MY 5445; MY5445; MY-5445; 1-(3-Chlorophenylamino)-4-phenylphthalazine. CAS No. 78351-75-4. Molecular formula: C20H14ClN3. Mole weight: 331.8. | |
| Native Aspergillus oryzae Ribonuclease T1 | Ribonuclease T1 (RNase T1) from Aspergillus oryzae is an endoribonuclease that hydrolyzes after G residues. Cleavage occurs between the 3-phosphate group of a guanidine ribonucleotide and 5-hydroxyl of the adjacent nucleotide. The initial product is a 2:3 cyclic phosphate nucleoside that is hydrolyzed to the corresponding 3-nucleoside phosphate. It differs from Pancreatic RNase in that it attacks the guanine sites specifically to yield 3'-GMP and oligonucleotides with a 3'-GMP terminal group. Applications: Ribonuclease t1 (rnase t1) from aspergillus oryzae is used to digest denatured rna prior to sequencing and is used for protein folding studies. Group: Enzymes. Synonyms: Ribonuclease T1; EC 3.1.27.3; g. Enzyme Commission Number: EC 3.1.27.3. CAS No. 9026-12-4. Rnase. Activity: 300,000-600,000 units/mg protein. Storage: -20°C. Form: ammonium sulfate suspension; Suspension in 2.8 M (NH4)2SO4 solution. Source: Aspergillus oryzae. Ribonuclease T1; EC 3.1.27.3; guanyloribonuclease; Aspergillus oryzae ribonuclease; RNase N1; RNase N2; ribonuclease N3; ribonuclease U1; ribonuclease F1; ribonuclease Ch; ribonuclease PP1; ribonuclease SA; RNase F1; ribonuclease C2; binase; RNase Sa; guanyl-specific RNase; RNase G; RNase T1; ribonuclease guaninenucleotido-2'-transferase (cyclizing); ribonuclease N3; ribonuclease N1; 9026-12-4. Cat No: NATE-0658. | |
| NG-amino-L-arginine hydrochloride | NG-amino-L-arginine is a nitric oxide synthase (NOS) inhibitor that inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 μM, respectively. It caused concentration-dependent, competitive, and stereoselective antagonism of acetylcholine-elicited relaxation and cyclic GMP accumulation. Synonyms: L-NAA; Nomega-amino-L-arginine hydrochloride; (2S) -2-amino-5-[[amino (hydrazinyl) methylidene]amino]pentanoic acid hydrochloride. Grades: ≥97%. CAS No. 1031799-40-2. Molecular formula: C6H15N5O2·HCl. Mole weight: 225.7. | |
| Phosphodiesterase 5A1 from Human, Recombinant | PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis. N-terminal gst-tagged 126 kda full-length protein. Applications: Phosphodiesterase (pde) is an enzyme that is used to breaks phosphodiester bonds. pde5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. pde5 is used to find novel pde5 inhibitors. Group: Enzymes. Synonyms: CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1. Phosphodiesterase. Mole weight: 126 kDa. Storage: -70°C. Form: Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN 20 and 3 mM DTT. Source: Sf9 cells. Species: Human. CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1. Cat No: NATE-0527. | |
| Prepro-Atrial Natriuretic Factor (26-55) (human) | Prepro-Atrial Natriuretic Factor (26-55) (human) is a polypeptide that increases renal cortical and medullary cyclic GMP levels. Prepro-Atrial Natriuretic Factor (26-55) (human) increases renal guanylate cyclase activity [1]. Uses: Scientific research. Group: Peptides. CAS No. 112160-82-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4811. | |
| Protein Kinase G II from rat, Recombinant | Protein Kinase G II (cGK-II) is a membrane-associated cGMP-dependent protein kinase found in rat intestine. This product is a recombinant rat isoform isolated from baculovirus-infected Sf 9 cells. >90% (sds-page), recombinant, expressed in baculovirus infected sf9 cells, solution. Group: Enzymes. Synonyms: cGK-II; 3':5'-Cyclic GMP dependent Protein Kinase; cGMP-dependent Protein Kinase II; Protein Kinase G II; PRKG2; protein kinase, cGMP-dependent, type II; cGMP-dependent protein kinase 2; PKG2. Purity: >90% (SDS-PAGE). PKG. Activity: ~0.7 U/mg. Form: solution. Source: baculovirus infected Sf9 cells. Species: Rat. cGK-II; 3':5'-Cyclic GMP dependent Protein Kinase; cGMP-dependent Protein Kinase II; Protein Kinase G II; PRKG2; protein kinase, cGMP-dependent, type II; cGMP-dependent protein kinase 2; PKG2. Cat No: NATE-0581. | |
| RU.521 | RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC 50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RU320521. CAS No. 2262452-06-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114180. | |
| Somatostatin-28 (sheep) | Somatostatin-28 (sheep) is derived from posttranslational cleavage of prosomatostatin, which in turn is derived from a larger precursor, preprosomatostatin. S-28 is an octacosapeptide first isolated from the duodenum of pigs. Unlike S-14, S-28 increases amylase secretion, cellular cyclic GMP and Ca2+ outfluxes in the guinea pig pancreatic acini. Synonyms: H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bridge: Cys17-Cys28); Somatostatin 1-28; L-seryl-L-alanyl-L-asparagyl-L-seryl-L-asparagyl-L-prolyl-L-alanyl-L-methionyl-L-alanyl-L-prolyl-L-arginyl-L-alpha-glutamyl-L-arginyl-L-lysyl-L-alanyl-glycyl-L-cysteinyl-L-lysyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine (17->28)-disulfide; 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontane, cyclic peptide deriv.; Cyclic somatostatin-28; Human somatostatin-28; Somatostatin-28 (human); Somatostatin-28 (pig); Somatostatin-28 (rat); Somatostatin-28 (sheep reduced), cyclic (17?28)-disulfide. Grades: ≥95% by HPLC. CAS No. 73032-94-7. Molecular formula: C137H207N41O39S3. Mole weight: 3148.56. | |
| Sp-8-Br-PET-cGMPS | Sp-8-Br-PET-cGMPS is an inhibitor of the retinal type cGMP-gated ion channel (cGMP antagonist) as well as a stimulator of cyclic GMP-dependent protein kinase I α and I ß (cGMP agonist), which is used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Bromo- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 172806-21-2. Molecular formula: C18H14BrN5O6PS · Na. Mole weight: 562.3. | |
| Sp-8-pCPT-PET-cGMPS | Sp-8-pCPT-PET-cGMPS is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Sp-8-Br-PET-cGMPS, Sp-8-pCPT-PET-cGMPS is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)-β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 1262749-63-2. Molecular formula: C24H18ClN5O6PS2 · Na. Mole weight: 626. | |
| Win-62005 | Win-62005 competitively and selectively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta (Kis= 25 and 26 nM for rat heart and canine aorta, respectively). Synonyms: 5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one; WIN 62005; WIN62005; WIN-62005. CAS No. 152633-54-0. Molecular formula: C12H10N4O. Mole weight: 226.23. | |
| Zaprinast | Zaprinast is a cyclic-GMP phosphodiesterase inhibitor with selectivity for PDE6, 5, 11 and 9 (IC50 = 0.15, 0.76, 12.0 and 29.0 μM, respectively). C-GMP acts as a mediator of signal transduction that relaxes vascular smooth muscles and increases blood flow. Therefore zaprinast exhibits vasodilating, relaxant, and diuretic effects. Zaprinast also acts as a putative GPR35 agonist. Synonyms: 2-(2-Propyloxyphenyl)-8-azapurin-6-one; 5-(2-propoxyphenyl)-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one. Grades: ≥99% by HPLC. CAS No. 37762-06-4. Molecular formula: C13H13N5O2. Mole weight: 271.28. | |
| Zaprinast (1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one) | A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of a. Group: Biochemicals. Alternative Names: 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one. Grades: Highly Purified. CAS No. 37762-06-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
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