Cyclic Gmp Phosphodiesterase Suppliers USA
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Product | Description | |
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8-Methoxymethyl-1-methyl-3-(2-methylpropyl) Xanthine (8-Methoxymethyl-IBMX) Quick inquiry Where to buy Suppliers range | A specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase. Group: Biochemicals. Alternative Names: 8-Methoxymethyl-IBMX. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
8-pCPT-PET-cGMP Quick inquiry Where to buy Suppliers range | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
CP 461 Quick inquiry Where to buy Suppliers range | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP 461; CP-461; CP461; OSI 461; UNII-68OJX9I7DT. N-benzyl-2-[6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide;hydrochloride; CAS: 227619-92-3 (CP-461 free base). Grades: >98%. CAS No. 227619-96-7. Molecular formula: C25H22ClFN2O. Mole weight: 420.91. | |
CP-461 free base Quick inquiry Where to buy Suppliers range | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP-461 free base; CP 461 free base; CP461 free base; N-benzyl-2-[(3Z)-6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide; UNII-824ZMS3BGL; OSI-461 free base. Grades: >98%. CAS No. 227619-92-3. Molecular formula: C25H21FN2O. Mole weight: 384.45. | |
Guanosine 3,5-Cyclic-13C,15N2 Monophosphate Quick inquiry Where to buy Suppliers range | Labeled Guanosine 3,5-Cyclic Monophosphate. Guanosine 3,5-Cyclic Monophosphate is a substituted Guanosine having cyclic phosphodiesterase activity. Group: Biochemicals. Alternative Names: Guanosine Cyclic-13C,15N2 3,5-(Hydrogen phosphate); Cyclic 3,5-Guanosine-13C,15N2 Monophosphate; Guanosine-13C,15N2 Monophosphate; GMP-13C,15N2. Grades: Highly Purified. CAS No. 40732-48-7-unlabeled. Pack Sizes: 500ug. Molecular Formula: C?¹³CH??N?¹?N?O?P, Molecular Weight: 348.18. US Biological Life Sciences. | Worldwide |
MMPX Quick inquiry Where to buy Suppliers range | MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC50 = 5.2 μM). It causes an increase in cGMP but not cAMP, prolonging signal transduction for cGMP-dependent pathways. Synonyms: 8-Methoxymethyl-3-isobutyl-1-methylxanthine; MMPX; 8-METHOXYMETHYL-1-METHYL-3-(2-METHYLPROPYL)XANTHINE; 8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE; 8-METHOXYMETHYL-3-ISOBUTYRYL-1-METHYLXANTHINE; 8-METHOXYMETHYL-IBMX. CAS No. 78033-08-6. Molecular formula: C12H18N4O3. Mole weight: 266.3. | |
MY-5445 Quick inquiry Where to buy Suppliers range | MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. Synonyms: MY 5445; MY5445; MY-5445; 1-(3-Chlorophenylamino)-4-phenylphthalazine. CAS No. 78351-75-4. Molecular formula: C20H14ClN3. Mole weight: 331.8. | |
Sp-8-Br-PET-cGMPS Quick inquiry Where to buy Suppliers range | Sp-8-Br-PET-cGMPS is an inhibitor of the retinal type cGMP-gated ion channel (cGMP antagonist) as well as a stimulator of cyclic GMP-dependent protein kinase I α and I ß (cGMP agonist), which is used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Bromo- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 172806-21-2. Molecular formula: C18H14BrN5O6PS · Na. Mole weight: 562.3. | |
Sp-8-pCPT-PET-cGMPS Quick inquiry Where to buy Suppliers range | Sp-8-pCPT-PET-cGMPS is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Sp-8-Br-PET-cGMPS, Sp-8-pCPT-PET-cGMPS is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)-β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 1262749-63-2. Molecular formula: C24H18ClN5O6PS2 · Na. Mole weight: 626. | |
Win-62005 Quick inquiry Where to buy Suppliers range | Win-62005 competitively and selectively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta (Kis= 25 and 26 nM for rat heart and canine aorta, respectively). Synonyms: 5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one; WIN 62005; WIN62005; WIN-62005. CAS No. 152633-54-0. Molecular formula: C12H10N4O. Mole weight: 226.23. | |
Zaprinast Quick inquiry Where to buy Suppliers range | Zaprinast is a cyclic-GMP phosphodiesterase inhibitor with selectivity for PDE6, 5, 11 and 9 (IC50 = 0.15, 0.76, 12.0 and 29.0 μM, respectively). C-GMP acts as a mediator of signal transduction that relaxes vascular smooth muscles and increases blood flow. Therefore zaprinast exhibits vasodilating, relaxant, and diuretic effects. Zaprinast also acts as a putative GPR35 agonist. Synonyms: 2-(2-Propyloxyphenyl)-8-azapurin-6-one; 5-(2-propoxyphenyl)-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one. Grades: ≥99% by HPLC. CAS No. 37762-06-4. Molecular formula: C13H13N5O2. Mole weight: 271.28. | |
Zaprinast (1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one) Quick inquiry Where to buy Suppliers range | A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of a. Group: Biochemicals. Alternative Names: 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one. Grades: Highly Purified. CAS No. 37762-06-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |