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| Product | Description | |
|---|---|---|
| 3',5'-cyclic-GMP phosphodiesterase | This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. Group: Enzymes. Synonyms: guanosine cyclic 3',5'-phosphate phosphodiesterase; cyclic GMP phosphodiesterase; cyclic 3',5'-GMP phosphodiesterase; cyclic guanosine 3',5'-monophosphate phosphodiesterase; cyclic guanosine 3',5'-phosphate phosphodiesterase; cGMP phosphodiesterase; cGMP-PDE. Enzyme Commission Number: EC 3.1.4.35. CAS No. 9068-52-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3719; 3',5'-cyclic-GMP phosphodiesterase; EC 3.1.4.35; 9068-52-4; guanosine cyclic 3',5'-phosphate phosphodiesterase; cyclic GMP phosphodiesterase; cyclic 3',5'-GMP phosphodiesterase; cyclic guanosine 3',5'-monophosphate phosphodiesterase; cyclic guanosine 3',5'-phosphate phosphodiesterase; cGMP phosphodiesterase; cGMP-PDE. Cat No: EXWM-3719. |  |
| 3',5'-cyclic-AMP phosphodiesterase | Requires Mg2+ or Mn2+ for activity. This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. Group: Enzymes. Synonyms: cAMP-specific phosphodiesterase; cAMP-specific PDE; PDE1; PDE2A; PDE2B; PDE4; PDE7; PDE8; PDEB1; PDEB2. Enzyme Commission Number: EC 3.1.4.53. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3736; 3',5'-cyclic-AMP phosphodiesterase; EC 3.1.4.53; cAMP-specific phosphodiesterase; cAMP-specific PDE; PDE1; PDE2A; PDE2B; PDE4; PDE7; PDE8; PDEB1; PDEB2. Cat No: EXWM-3736. | |
| 3',5'-cyclic-nucleotide phosphodiesterase | Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP. Group: Enzymes. Synonyms: cyclic 3',5'-mononucleotide phosphodiesterase; PDE; cyclic 3',5'-nucleotide phosphodiesterase; cyclic 3',5'-phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; 3',5'-cyclonucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase; 3', 5'-cyclic nucleoside monophosphate p. Enzyme Commission Number: EC 3.1.4.17. CAS No. 9040-59-9. PDE. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3716; 3',5'-cyclic-nucleotide phosphodiesterase; EC 3.1.4.17; 9040-59-9; cyclic 3',5'-mononucleotide phosphodiesterase; PDE; cyclic 3',5'-nucleotide phosphodiesterase; cyclic 3',5'-phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; 3',5'-cyclonucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase; 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP); cyclic 3',5-nucleotide monophosphate phosphodiesterase; nucleoside 3',5'-cyclic phosphate diesterase; nucleoside-3',5-monophosphate phosphodiesterase. Cat No: EXWM-3716. | |
| 8-CPT-Cyclic AMP sodium | 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 ?M. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC50 |  |
| 8-Methoxymethyl-1-methyl-3-(2-methylpropyl) Xanthine (8-Methoxymethyl-IBMX) | A specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase. Group: Biochemicals. Alternative Names: 8-Methoxymethyl-IBMX. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| 8-pCPT-PET-cGMP | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. |  |
| Calmodulin antagonist-1 | Calmodulin antagonist-1 is a calmodulin (CaM) antagonist that inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50 = 28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50 = 375 μM) in a competitive fashion with respect to cyclic GMP (Ki = 300 μM). Uses: Neoplasm inhibitor. Synonyms: N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride; W8 Hydrochloride; N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide Monohydrochloride. Grade: ≥95%. CAS No. 78957-84-3. Molecular formula: C14H18Cl2N2O2S. Mole weight: 349.28. | |
| CP 461 | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP 461; CP-461; CP461; OSI 461; UNII-68OJX9I7DT. N-benzyl-2-[6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide; hydrochloride; CAS: 227619-92-3 (CP-461 free base). Grade: >98%. CAS No. 227619-96-7. Molecular formula: C25H22ClFN2O. Mole weight: 420.91. | |
| CP-461 free base | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP-461 free base; CP 461 free base; CP461 free base; N-benzyl-2-[(3Z)-6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide; UNII-824ZMS3BGL; OSI-461 free base. Grade: >98%. CAS No. 227619-92-3. Molecular formula: C25H21FN2O. Mole weight: 384.45. | |
| cyclic-guanylate-specific phosphodiesterase | Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3,5-guanylate, the product of EC 2.7.7.65, diguanylate cyclase and an allosteric activator of EC 2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive. It is the balance between these two enzymes that determines the cellular level of c-di-GMP. Group: Enzymes. Synonyms: cyclic bis(3?5')diguanylate phosphodiesterase; c-di-GMP-specific phosphodiesterase; c-di-GMP phosphodiesterase; phosphodiesterase (misleading); phosphodiesterase A1; PDEA1; VieA. Enzyme Commission Number: EC 3.1.4.52. CAS No. 338732-46-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3735; cyclic-guanylate-specific phosphodiesterase; EC 3.1.4.52; 338732-46-0; cyclic bis(3?5')diguanylate phosphodiesterase; c-di-GMP-specific phosphodiesterase; c-di-GMP phosphodiesterase; phosphodiesterase (misleading); phosphodiesterase A1; PDEA1; VieA. Cat No: EXWM-3735. | |
| D(+)-Raffinose pentahydrate | D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA ( K d = 32 μM) and GtfC. D(+)-Raffinose pentahydrate reduces cyclic diguanylate (c-di-GMP) by increased activity of a c-di-GMP specific phosphodiesterase. D(+)-Raffinose pentahydrate interferes with GTF function. D(+)-Raffinose pentahydrate decreases IL-4 and IL-5 mRNA. D(+)-Raffinose pentahydrate exhibits biofilm-inhibitory activity against Pseudomonas aeruginosa and Streptococcus mutans and inhibits allergic airway eosinophilia [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: D-Raffinose pentahydrate. CAS No. 17629-30-0. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-N1938. | |
| Guanosine 3,5-Cyclic-13C,15N2 Monophosphate | Labeled Guanosine 3,5-Cyclic Monophosphate. Guanosine 3,5-Cyclic Monophosphate is a substituted Guanosine having cyclic phosphodiesterase activity. Group: Biochemicals. Alternative Names: Guanosine Cyclic-13C,15N2 3,5-(Hydrogen phosphate); Cyclic 3,5-Guanosine-13C,15N2 Monophosphate; Guanosine-13C,15N2 Monophosphate; GMP-13C,15N2. Grades: Highly Purified. CAS No. 40732-48-7-unlabeled. Pack Sizes: 500ug. Molecular Formula: C?¹³CH??N?¹?N?O?P, Molecular Weight: 348.18. US Biological Life Sciences. | Worldwide |
| Phosphodiesterase 5A1 from Human, Recombinant | PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis. N-terminal gst-tagged 126 kda full-length protein. Applications: Phosphodiesterase (pde) is an enzyme that is used to breaks phosphodiester bonds. pde5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. pde5 is used to find novel pde5 inhibitors. Group: Enzymes. Synonyms: CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1. Phosphodiesterase. Mole weight: 126 kDa. Storage: -70°C. Form: Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN 20 and 3 mM DTT. Source: Sf9 cells. Species: Human. CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1. Cat No: NATE-0527. | |
| Zaprinast (1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one) | A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of a. Group: Biochemicals. Alternative Names: 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one. Grades: Highly Purified. CAS No. 37762-06-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
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