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| Product | Description | |
|---|---|---|
| cyclic GMP-AMP synthase | Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines. Group: Enzymes. Synonyms: cGAMP synthase; cGAS. Enzyme Commission Number: EC 2.7.7.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3299; cyclic GMP-AMP synthase; EC 2.7.7.86; cGAMP synthase; cGAS. Cat No: EXWM-3299. |  |
| 2',3'-cGAMP | 2',3'-cGAMP was considered to be the metazoan second messenger which is produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. It can activate innate immunity by directly binding the endoplasmic reticulum-resident receptor STING (stimulator of interferon genes). Synonyms: Cyclic [G(2',5')pA(3',5')p]; 2'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide; 2',3'-Cyclic guanosine adenosine monophosphate; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate; 2'-3'-cyclic GMP-AMP; cGAMP(2'→5'); c[G(2',5')pA(3',5')p]; Cyclic Gp(2'→5')Ap(3'→5'). Grade: ≥95%. CAS No. 1441190-66-4. Molecular formula: C20H24N10O13P2. Mole weight: 674.41. |  |
| cGAS-IN-2 | cGAS-IN-2 (compound 109) is a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), with IC 50 of 0.01512 μM for h-cGAS [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765273-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160546. |  |
| CU-32 | CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (IC50 = 0.45 μM). Synonyms: methyl 4-amino-6-((4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate. Grade: 95%. CAS No. 2400954-16-5. Molecular formula: C11H10IN5O2. Mole weight: 371.13. | |
| CU-76 | An inhibitor of cyclic GMP-AMP synthase (IC50 = 0.24 μM). Synonyms: Methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate. Grade: 95%. CAS No. 2400954-58-5. Molecular formula: C11H8F2IN5O2. Mole weight: 407.11. | |
| G140 | G140 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor, with IC50s of 14.0?nM and 442?nM for h-cGAS and m-cGAS, respectively. It has anti-inflammatory activity. Synonyms: 1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone; Ethanone, 1-[6,7-dichloro-1,3,4,5-tetrahydro-9-(1-methyl-1H-pyrazol-3-yl)-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy-; 1-[6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone. Grade: ≥98%. CAS No. 2369751-07-3. Molecular formula: C17H16Cl2N4O2. Mole weight: 379.24. | |
| G140 | G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0?nM and 442?nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2369751-07-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133916. | |
| G150 | G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC 50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2369751-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128583. | |
| G150 | G150 is a potent and selective inhibitor of human cyclic GMP-AMP synthase (cGAS) with IC50 of 10.2 nM. CAS No. 2369751-30-2. Molecular formula: C18H16Cl2N4O2. Mole weight: 391.25. | |
| PF-06928215 | PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 ??. PF-06928215 has a high binding affinity of 0.2 ?M (Kd)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2378173-15-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114182. | |
| RU.521 | RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC 50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RU320521. CAS No. 2262452-06-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114180. | |
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