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| Product | Description | |
|---|---|---|
| Cyclooxygenase 1 from Human, Recombinant | COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. COX-1. Mole weight: ~70 kDa. Activity: >20,000 units/mg. Stability: > 6 months. Storage: -80°C (as supplied); avoid freeze/thaw cycles by aliquoting protein. Form: 80 mM Tris, pH 8.0, containing 0.1% polysorbate 20, 300 uM DDC, and 10% glycerol. Source: Sf21 cells. Species: Human. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-1237. |  |
| Cyclooxygenase 2 from Human, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. COX-2. Mole weight: 70 kDa. Activity: >8,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Human. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1238. | |
| Cyclooxygenase 2 from Ovine, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Purity: >80% estimated by SDS-PAGE. COX-2. Mole weight: ~70 kDa. Activity: >20,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Ovine. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1239. | |
| COX 2 Downstream Primer, 724bp amplimer (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2) | COX 2 Downstream Primer, 724bp amplimer (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2). Group: Molecular Biology. Pack Sizes: 50uM. US Biological Life Sciences. |  Worldwide |
| COX 2 Upstream Primer, 724bp amplimer (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2) | COX 2 Upstream Primer, 724bp amplimer (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2). Group: Molecular Biology. Pack Sizes: 50uM. US Biological Life Sciences. | Worldwide |
| Native Sheep Cyclooxygenase 1 | COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Enzyme Commission Number: EC 1.14.99.1. CAS No. 9055-65-6. Purity: > 95% (SDS-PAGE). COX-1. Mole weight: dimer subunit mol wt 70 kDa. Activity: > 40,000 units/mg protein. Storage: -70°C. Form: aqueous solution. Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN 20 and 300 μM diethyldithiocarbamate. Source: Sheep. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-0149. | |
| 1,1-Bis(p-isobutylphenyl)ethane | 1,1-Bis(p-isobutylphenyl)ethane (Ibuprofen EP Impurity R) is an impurity in the synthesis of Ibuprofen (I140000); a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Group: Biochemicals. Grades: Highly Purified. CAS No. 102120-87-6. Pack Sizes: 100mg, 1g. Molecular Formula: C22H30. US Biological Life Sciences. | Worldwide |
| 1,2,4-Triazol-4-amine | 1,2,4-Triazol-4-amine is an intermediate used to prepare potent, selective, and orally active cyclooxygenase-?2 inhibitors. It is also used to synthesize hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 584-13-4. Pack Sizes: 1g, 10 g. Molecular Formula: C2H4N4. US Biological Life Sciences. | Worldwide |
| 1-(2,6-Dichloro-4-hydroxphenyl)-1,3-dihydroindol-2-one-13C6 | 1-(2,6-Dichloro-4-hydroxphenyl)-1,3-dihydroindol-2-one-13C6 is an intermediate in synthesizing 4-Hydroxy Diclofenac-13C6, a labelled metabolite of Diclofenac, which is a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C813C6H9Cl2NO2. US Biological Life Sciences. | Worldwide |
| 1-(2-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester | 1-(2-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester is an intermediate used to prepare 4-Dechloro-2-chloroindomethacin (D226240), an impurity of Indomethacin (I641000) which inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). Group: Biochemicals. Grades: Highly Purified. CAS No. 1568-35-0. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H18ClNO4. US Biological Life Sciences. | Worldwide |
| 1-(2-Methylpropyl)-4-[(3RS)-3-[4(-2-methylpropyl)-phenyl]butyl]benzene | 1-(2-Methylpropyl)-4-[(3RS)-3-[4(-2-methylpropyl)-phenyl]butyl]benzene is an impurity in the synthesis of Ibuprofen (I140000); a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C24H34, Molecular Weight: 322.529999999999. US Biological Life Sciences. | Worldwide |
| 12(S)-HHTrE | 12(S)-HHTrE is a product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of human platelets. It is biosynthesized by thromboxane (TXA2) synthase from prostaglandin H2 (PGH2) concurrently with TXA2. Synonyms: 12(S)-HHT; 12-hydroxyheptadecatrienoic acid. Grades: ≥95%. CAS No. 54397-84-1. Molecular formula: C17H28O3. Mole weight: 280.4. |  |
| 1-(3,4-Dichlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester | 1-(3,4-Dichlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester is an intermediate used to prepare 3-Chloroindomethacin (C367395), an impurity of Indomethacin (I641000) which inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). Group: Biochemicals. Grades: Highly Purified. CAS No. 942431-82-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H17Cl2NO4, Molecular Weight: 406.26. US Biological Life Sciences. | Worldwide |
| 1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester | 1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester is an intermediate used to prepare 4-Dechloro-3-chloroindomethacin (D226245), an impurity of Indomethacin (I641000) which inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). Group: Biochemicals. Grades: Highly Purified. CAS No. 1568-36-1. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H18ClNO4. US Biological Life Sciences. | Worldwide |
| 1-(4-sec-Butylphenyl)ethanone | 1-(4-sec-Butylphenyl)ethanone is a useful synthetic intermediate in the synthesis of 2-(p-sec-Butylphenyl)propionic Acid (B692720); an impurity of Ibuprofen (I140000) which is a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Group: Biochemicals. Grades: Highly Purified. CAS No. 7645-81-0. Pack Sizes: 1g, 10g. Molecular Formula: C12H16O, Molecular Weight: 176.25. US Biological Life Sciences. | Worldwide |
| 15-Keto Prostaglandin E2 | 15-Keto Prostaglandin E2 is a lipid compound derived from arachidonic acid by the action of cyclooxygenases. Prostaglandins act locally as messenger molecules in a variety of physiological processes. Group: Biochemicals. Grades: Highly Purified. CAS No. 26441-05-4. Pack Sizes: 10mg, 25mg. Molecular Formula: C20H30O5, Molecular Weight: 350.45. US Biological Life Sciences. | Worldwide |
| 17-Phenyl-trinor-prostaglandin E2 | 17-Phenyl-trinor-prostaglandin E2 is a synthetic analog of PGE2 and an agonist at the EP1 and EP3 receptor (1). Prostaglandin E2(PGE2) regulates neuroinflammatory responses and is upregulated in brain injury by cyclooxygenase 2 (COX-?2) and membrane-bound PGE synthase. 17-Phenyl-trinor-prostaglandin E2 can be used to investigate inflammatory signaling pathways (2). Group: Biochemicals. Grades: Highly Purified. CAS No. 38315-43-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C23H30O5, Molecular Weight: 386.48. US Biological Life Sciences. | Worldwide |
| 1-?Bromononane | 1-?Bromononane is a useful synthetic intermediate. It is used in the synthesis of cyclooxygenase-2 (COX-2), a new class of selective COX-2 inactivators. It is also used to prepare alkylimidazoles by N-alkylation of imidazoles as antibacterial agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 693-58-3. Pack Sizes: 1g, 5g. Molecular Formula: C9H19Br. US Biological Life Sciences. | Worldwide |
| 1-Ethyl-1,3,4,9-tetrahydro-8-(1-methylethyl)pyrano[3,4-b]indole-1-ethanol | SDX-309 is a potent indole-pyran analogs of SDX-101 (R-etodolac, E933090) which has anti-tumor activity unrelated to cyclooxygenase-2 inhibition. Group: Biochemicals. Grades: Highly Purified. CAS No. 849630-33-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C18H25NO2, Molecular Weight: 287.399999999999. US Biological Life Sciences. | Worldwide |
| 1-Hydroxy-o-carborane | 1-Hydroxy-o-carborane is a reactant used in the synthetic preparation of Asborin, which is the carbaborane analog of Aspirin, proved to be an active cyclooxygenase (COX) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 23987-99-7. Pack Sizes: 10mg, 20mg. Molecular Formula: C2H12B10O, Molecular Weight: 160.229999999999. US Biological Life Sciences. | Worldwide |
| 1-Isopropyl Etodolac | A derivative of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Synonyms: 8-Ethyl-1,3,4,9-tetrahydro-1-(1-methylethyl)-Pyrano[3,4-b]indole-1-acetic Acid. Grades: > 95%. CAS No. 849630-65-5. Molecular formula: C18H23NO3. Mole weight: 301.39. | |
| 1-Propyl Etodolac | A derivative of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Synonyms: 1-Ethyl-1,3,4,9-tetrahydro-8-(1-methylethyl)-Pyrano[3,4-b]indole-1-acetic Acid. Grades: > 95%. CAS No. 57816-83-8. Molecular formula: C18H23NO3. Mole weight: 301.39. | |
| 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid | 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid is a potent vasoconstrictor produced in vascular smooth muscle cells. Its EC50 value is < 10 nM. It is a cytochrome P450 metabolite. It induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop in kidney. It is involved in the regulation of sodium, potassium, and chloride transport in the renal tubules. It is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction in rat cerebral microvessels. It is excreted mainly as the glucuronide conjugate. It can be further metabolized by cyclooxygenase to 20-hydroxy PGG2 and 20-hydroxy PGH2. It regulates blood pressure in a complex way. It sensitizes smooth muscle cells to the constrictor stimuli and promotes the proliferation of endothelial cells. It has the ability to induce proinflammatory changes. It blocked the 70 pS K+ channel localized in the apical membrane in TALH cells. It was found to be a potent vasoconstrictor through activating the kinase pathways that contribute to the vascular tone regulation including MAPK, PKC, rho kinase and src-type tyrosine kinase. It may similarly regulate blood pressure and contribute to the development of stroke and heart attacks. Synonyms: 20-Hydroxyeicosatetraeonic acid; 20 Hydroxyeicosatetraeonic acid; 20Hydroxyeicosatetraeonic acid; 20HETE; 20 HETE; 20-HETE;(5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid;20-Hydroxyeicosatetraenoic acid;20-hydroxy-5,8,11,14-eicosatetraenoic acid. Grades:>98%. CAS No. 79551-86-3. Molecular formula: C20H32O3. Mole weight: 320.47. | |
| 2-[2- (2, 6-Dichloro-4-hydroxphenylamino) phenyl-d4]-N, N-dimethylacetamide | 2-[2- (2, 6-Dichloro-4-hydroxphenylamino) phenyl-d4]-N, N-dimethylacetamide is an intermediate in the synthesis of 4-Hydroxy Diclofenac-d4 (H825227), is an isotope labeled metabolite of Diclofenac, a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1382084-40-3. Pack Sizes: 500ug, 5mg. Molecular Formula: C16H12D4Cl2N2O2, Molecular Weight: 343.24. US Biological Life Sciences. | Worldwide |
| 2, ?2'-?[(3, ?3', ?5, ?5'-Tetrachloro[1, ?1'-?biphenyl]?-?4, ?4'-?diyl)?diimino]?bis-benzeneacetic Acid | 2, ?2'-?[(3, ?3', ?5, ?5'-Tetrachloro[1, ?1'-?biphenyl]?-?4, ?4'-?diyl)?diimino]?bis-benzeneacetic Acid is an impurity of Diclofenac (D436450), a nonsteroidal anti-inflammatory compound and a cyclooxygenase (COX) inhibitor (1,2,3). Diclofenac exhibits anti-inflammatory, analgesic, and antipyretic properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 1609187-32-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H20Cl4N2O4, Molecular Weight: 590.28. US Biological Life Sciences. | Worldwide |
| 2-?[ (2, ?6-Dichloro-?4-?oxo-?2, ?5-?cyclohexadien-?1-?ylidene) ?amino]?-benzeneacetic Acid | 2-?[ (2, ?6-Dichloro-?4-?oxo-?2, ?5-?cyclohexadien-?1-?ylidene) ?amino]?-benzeneacetic Acid is a related compound of Diclofenac (D436450), a nonsteroidal anti-inflammatory compound and a cyclooxygenase (COX) inhibitor (1,2,3). Diclofenac exhibits anti-inflammatory, analgesic, and antipyretic properties. 2-?[ (2, ?6-Dichloro-?4-?oxo-?2, ?5-?cyclohexadien-?1-?ylidene) ?amino]?-benzeneacetic Acid can be used to study cytochrome P 450 isoforms involved in the bioactivation of diclofenac to reactive p-benzoquinone imines (4). Group: Biochemicals. Grades: Highly Purified. CAS No. 928343-25-3. Pack Sizes: 500ug, 1mg. Molecular Formula: C14H9Cl2NO3, Molecular Weight: 310.13. US Biological Life Sciences. | Worldwide |
| 2-(2,6-Dichlorophenoxy)-N-phenylacetamide | 2-(2,6-Dichlorophenoxy)-N-phenylacetamide is a related compound of Diclofenac (D436450), a nonsteroidal anti-inflammatory compound and a cyclooxygenase (COX) inhibitor (1,2,3). Diclofenac exhibits anti-inflammatory, analgesic, and antipyretic properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 146607-19-4. Pack Sizes: 25mg, 50mg. Molecular Formula: C14H11Cl2NO2. US Biological Life Sciences. | Worldwide |
| 2-[ (2, 6-Dichlorophenyl) amino]benzaldehyde (Diclofenac impurity) | 13C Labeled Diclofenac Sodium Salt is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Group: Biochemicals. Alternative Names: N- (2, 6-Dichlorophenyl) anthranilaldehyde; 2- (2, 6-Dichloroanilino) benzaldehyde; o- (2, 6-Dichloroanilino) benzaldehyde; Diclofenac Aldehyde. Grades: Highly Purified. CAS No. 22121-58-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2-[ (4-Acetylphenyl) methyl]cyclopentan-1-one | 2-[ (4-Acetylphenyl) methyl]cyclopentan-1-one is a possible metabolite of Loxoprofen (L472900, Na salt), a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. It becomes active after metabolism in the body and inhibits the activation of cyclooxygenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 96824-28-1. Pack Sizes: 5mg, 10mg. Molecular Formula: C14H16O2, Molecular Weight: 216.28. US Biological Life Sciences. | Worldwide |
| 2- (4-Isobutylphenyl) propanal | 2- (4-Isobutylphenyl) propanal is an impurity of the drug Ibuprofen (I140000), a selective cyclooxygenase inhibitor that also inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Group: Biochemicals. Grades: Highly Purified. CAS No. 51407-46-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C13H18O, Molecular Weight: 190.28. US Biological Life Sciences. | Worldwide |
| 2,5-Dimethyl Celecoxib | A non-cyclooxygenase-2 inhibitor analog of Celecoxib. The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib. Group: Biochemicals. Alternative Names: 4-[5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; DMC. Grades: Highly Purified. CAS No. 457639-26-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2-Amino-5-chloronicotinaldehyde | 2-Amino-5-chloronicotinaldehyde is an intermediate used to prepare benzopyrancarboxylates and quinolinecarboxylates as cyclooxygenase-2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 54856-61-0. Pack Sizes: 50mg, 100mg. Molecular Formula: C6H5ClN2O, Molecular Weight: 156.57. US Biological Life Sciences. | Worldwide |
| 2-Benzothiazolethiol | 2-Benzothiazolethiol is an intermediate used to synthesize benzothiazole derivatives as cyclooxygenase inhibitors. It is also used to prepare pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 149-30-4. Pack Sizes: 100mg, 5g. Molecular Formula: C7H5NS2. US Biological Life Sciences. | Worldwide |
| 2-Bromo-1-furan-2-yl-ethanone | 2-Bromo-1-furan-2-yl-ethanone is a reagent that is used in the preparation of diaryldi hydropyrrolizine derivatives and their activity as cyclooxygenase and lipoxygenase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 15109-94-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H5BrO2, Molecular Weight: 189.01. US Biological Life Sciences. | Worldwide |
| 2-Bromoethylcyclopropane | 2-Bromoethylcyclopropane is used as a reagent to synthesize 22-Hydroxycholesterol (H918010) derivatives, compounds that act as serum cholesterol lowering agents. 2-Bromoethylcyclopropane is also used to prepare pyridazinones, compounds that act as cyclooxygenase 2-inhibitors (they possess anti-inflammatory and antiangiogenic effects). Group: Biochemicals. Grades: Highly Purified. CAS No. 36982-56-6. Pack Sizes: 50mg, 100mg. Molecular Formula: C5H9Br. US Biological Life Sciences. | Worldwide |
| 2-Bromomethyl-6-nitrobenzoic Acid Methyl Ester | 2-Bromomethyl-6-nitrobenzoic Acid Methyl Ester is a potential cyclooxygenase inhibitor derived from thalidomide (T338850), an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma. Group: Biochemicals. Alternative Names: Methyl 2-(2-Bromomethyl)-6-nitrobenzoate; Methyl 2-(Bromomethyl)-6-nitrobenzoate. Grades: Highly Purified. CAS No. 61940-21-4. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 2-Chloro-6- (trifluoromethyl) aniline | 2-Chloro-6- (trifluoromethyl) aniline is a molecular determinant for the selective inhibition of cyclooxygenase-2 by lumiracoxib. Group: Biochemicals. Grades: Highly Purified. CAS No. 433-94-3. Pack Sizes: 1g, 5g. Molecular Formula: C7H5ClF3N, Molecular Weight: 195.57. US Biological Life Sciences. | Worldwide |
| 2-Ethoxyphenol | 2-Ethoxyphenol is used in the studies on the inhibition of oral bacteria by phenolic compounds. Studies on the prostagladins cyclooxygenase inhibition by phenolic compounds. Reagent for the stereoselective preparation of (arylthiomethyl) morpholines as selective norepinephrine reuptake inhibitors and dual serotonin / norepinephrine reuptake inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 94-71-3. Pack Sizes: 5g, 25g. Molecular Formula: C8H10O2, Molecular Weight: 138.16. US Biological Life Sciences. | Worldwide |
| 2-Hydroxyacetophenone | 2-Hydroxyacetophenone is a useful reactant for synthesis of diarylpyrazoles as cyclooxygenase 2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 582-24-1. Pack Sizes: 5g, 25g. Molecular Formula: C8H8O2, Molecular Weight: 136.15. US Biological Life Sciences. | Worldwide |
| 2-Iodobenzotrifluoride | 2-Iodobenzotrifluoride acts as a reagent in the preparation, cyclooxygenase-1 inhibitory activity, and docking studies of aminoalkoxyphenyl benzamide s. Prepartion and SAR of tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 444-29-1. Pack Sizes: 1g, 5g. Molecular Formula: C7H4F3I, Molecular Weight: 272.01. US Biological Life Sciences. | Worldwide |
| 2-Methyl-Celecoxib | 2-Methyl-Celecoxib is an analog of the anti-inflammatory drug Celecoxib (C251000). Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 170570-09-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C18H16F3N3O2S, Molecular Weight: 395.4. US Biological Life Sciences. | Worldwide |
| 2-Oleoyl glycerol | 2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol, is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. Synonyms: 2-Monoolein; 2-OG; 2-Monooleoylglycerol; 2-Glyceryl monooleate; Glyceryl 2-oleate; 2-(9Z-octadecenoyl)-sn-glycerol. Grades: >99%. CAS No. 3443-84-3. Molecular formula: C21H40O4. Mole weight: 356.54. | |
| 2-(p-sec-Butylphenyl)propionic Acid | 2-(p-sec-Butylphenyl)propionic Acid (Ibuprofen EP Impurity O) is an impurity of Ibuprofen (I140000); a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Group: Biochemicals. Grades: Highly Purified. CAS No. 64451-76-9. Pack Sizes: 250mg, 2.5g. Molecular Formula: C13H18O2, Molecular Weight: 206.28. US Biological Life Sciences. | Worldwide |
| 2-(p-sec-Butylphenyl)propionic Acid-d3 | 2-(p-sec-Butylphenyl)propionic Acid-d3 is the isotope labelled analog of 2-(p-sec-Butylphenyl)propionic Acid (B692720); an impurity of Ibuprofen (I140000) which is a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C13H15D3O2, Molecular Weight: 209.3. US Biological Life Sciences. | Worldwide |
| 3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazole | An impurity of Celecoxib, a cyclooxygenase 2 inhibitor. Synonyms: 3-(4-methylphenyl)-5-(trifluoromethyl)pyrazole; 3-(Trifluoromethyl)-5-p-tolyl-1H-pyrazole; 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole. Grades: 95 %. CAS No. 219986-64-8. Molecular formula: C11H9F3N2. Mole weight: 226.2. | |
| 3-(7-Ethyl-3-(2-hydroxyethyl)-1H-indol-2-yl)pent-2-enoic Acid | 3-(7-Ethyl-3-(2-hydroxyethyl)-1H-indol-2-yl)pent-2-enoic Acid is a a double bond isomer of Etodolac Impurity L which is an impurity of Etodolac (racemic, E933100), a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2). Etodolac displays anti-inflammatory effects in both adjuvant arthritic and normal rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C17H21NO3, Molecular Weight: 287.35. US Biological Life Sciences. | Worldwide |
| 4-(2-Aminoanilino)pyridine | An intermediate used to prepare Timiperone as well as cyclooxygenase-2 inhibitors and adrenergic agents. Group: Biochemicals. Alternative Names: N1-4-Pyridinyl-1,2-benzenediamine; NSC 155702. Grades: Highly Purified. CAS No. 65053-26-1. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 4-(2-Aminoanilino)pyridine-d4 | An intermediate used to prepare labeled Timiperone as well as cyclooxygenase-2 inhibitors and adrenergic agents. Group: Biochemicals. Alternative Names: N1-4-Pyridinyl-1,2-benzenediamine-d4; NSC 155702-d4. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 4-Desmethyl-3-methyl Celecoxib | A meta positional isomer of Celecoxib with selective inhibitory activity against human cyclooxygenase-2. Group: Biochemicals. Alternative Names: 4-[5-(3-Methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide. Grades: Highly Purified. CAS No. 170570-01-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 4-Hydroxy Diclofenac | A metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound an cyclooxygenase (COX) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 64118-84-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 4-Hydroxy Diclofenac-13C6 (contain 3% unlabeled) | 13C Labeled Diclofenac Sodium Salt is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Group: Biochemicals. Alternative Names: 2-[ (2, 6-Dichloro-4-hydroxyphenyl)amino] (benzene-13C6)acetic Acid. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 4-(NITROOXY)BUTYL (2S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOATE | Naproxcinod, a nitro compound, has been found to be a nitric oxide donor as well as a cyclooxygenase inhibitor that was once studied aginast duchenne muscular dystrophy. Uses: Nitric oxide donors. Synonyms: Naproxcinod; Nitronaproxen; HCT 3012; HCT3012; HCT-3012; AZD 3582; AZD3582; AZD-3582; Naproxen-n-butyl nitrate; 4-nitrooxybutyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate. Grades: 98%. CAS No. 163133-43-5. Molecular formula: C18H21NO6. Mole weight: 347.36. | |
| 5-Hydroxy Diclofenac | A metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound an cyclooxygenase (COX) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 69002-84-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 5-Methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol | An intermediate for the preparation of Valdecoxib. Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis, rheumatoid arthritis, etc. Valdecoxib exhibits a selectively inhibitory effect of cyclooxygenase-2. Uses: Intermediate for the preparation of valdecoxib. Synonyms: 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol. CAS No. 181696-73-1. Molecular formula: C16H15NO2. Mole weight: 253.30. | |
| 6-Cyano-2-methylpyridine | Intermediate in the preparation of selective cyclooxygenase-2 inhibitors and calcium antagonists. Group: Biochemicals. Alternative Names: 6-Methyl-2-pyridinecarbonitrile; 2-Methyl-6-cyanopyridine; 6-Cyano-2-methylpyridine; 6-Methyl-2-cyanopyridine; 6-Methyl-2-pyridinecarbonitrile; 6-Methylpicolinonitrile; NSC 26022. Grades: Highly Purified. CAS No. 1620-75-3. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 6-Hydroxy Etodolac | A derivative of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Synonyms: 1,8-Diethyl-1,3,4,9-tetrahydro-6-hydroxypyrano[3,4-b]indole-1-acetic Acid. Grades: > 95%. CAS No. 101901-06-8. Molecular formula: C17H21NO4. Mole weight: 303.36. | |
| 7,3',4'-Tri-O-Methylluteolin | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 29080-58-8. Molecular formula: C18H16O6. Mole weight: 328.32. Purity: 0.99. Product ID: ACM29080588. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 8-Isopropyl Etodolac | A derivative of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Synonyms: 1-Ethyl-1,3,4,9-tetrahydro-8-(1-methylethyl)-pyrano[3,4-b]indole-1-acetic Acid. Grades: > 95%. CAS No. 57917-63-2. Molecular formula: C18H23NO3. Mole weight: 301.39. | |
| 8-Propyl Etodolac | A derivative of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Synonyms: 1-Ethyl-1,3,4,9-tetrahydro-8-propyl-pyrano[3,4-b]indole-1-acetic Acid. Grades: > 95%. CAS No. 57817-27-3. Molecular formula: C18H23NO3. Mole weight: 301.39. | |
| Acemetacin | Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TVX 1322. CAS No. 53164-05-9. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-B0482. |  |
| Acetaminophen | Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 ( COX-2 ) inhibitor with an IC 50 of 25.8 μM; is a widely used antipyretic and analgesic agent. [1] [2] [3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [4]. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide. CAS No. 103-90-2. Pack Sizes: 500 mg; 5 g; 10 g. Product ID: HY-66005. | |
| Acetaminophen glucuronide | Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) [1] [2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: APAP-glu. CAS No. 16110-10-4. Pack Sizes: 5 mg. Product ID: HY-113083. | |
| Acetaminophen (Standard) | Acetaminophen (Standard) is the analytical standard of Acetaminophen. This product is intended for research and analytical applications. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 ( COX-2 ) inhibitor with an IC 50 of 25.8 μM; is a widely used antipyretic and analgesic agent [1] [2] [3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Paracetamol (Standard); 4-Acetamidophenol (Standard); 4'-Hydroxyacetanilide (Standard). CAS No. 103-90-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-66005R. | |
| Acetylsalicylic Acid Impurity E | Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several pro inflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein. Synonyms: NSC-49171. Grades: >98%. CAS No. 552-94-3. Molecular formula: C14H10O5. Mole weight: 258.23. | |
| AKR1C3 Inhibitor (3- (4- (Trifluoromethyl) phenylamino) benzoic Acid) | A cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17b-hydroxysteroid dehydrogenase) (IC50 = 60nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50uM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100uM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Ampiroxicam | Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP 65703. CAS No. 99464-64-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17484. | |
| Ampiroxicam | Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Synonyms: CP 65703; CP65703; CP-65703. Grades: >98%. CAS No. 99464-64-9. Molecular formula: C20H21N3O7S. Mole weight: 447.46. | |
| Apricoxib | Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. Synonyms: CS-701; CS 701; CS701; TG01; TG 01; TG-01; R-109339, R 109339; R109339; Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-. CAS No. 197904-84-0. Molecular formula: C19H20N2O3S. Mole weight: 356.44. | |
| Asiaticoside | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
| Aspirin | Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2 , with IC 50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase , and can prevent coronary artery and cerebrovascular thrombosis [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetylsalicylic Acid; ASA. CAS No. 50-78-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-14654. | |
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