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| Product | Description | |
|---|---|---|
| Cyclothiazide | Cyclothiazide, a positive allosteric modulator of AMPA receptors , is used frequently to block the desensitization of both native and heterologously expressed AMPA receptors. Cyclothiazide is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2259-96-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101165. |  |
| Cyclothiazide | Cyclothiazide has been found to be a subunit-specific inhibitor of GABAC receptors and could be used as a diuretic agent as well as antihypertensive agent. Uses: Antihypertensive agents; diuretics, thiazide. Synonyms: 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide. Grades: ≥98% by HPLC. CAS No. 2259-96-3. Molecular formula: C14H16ClN3O4S2. Mole weight: 389.87. |  |
| Cyclothiazide | Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors. Group: Biochemicals. Alternative Names: 3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide; Anhydron; Aquirel; Doburil; Fluidil; Lilly 35483; MDi 193; Renazide; Valmiran. Grades: Highly Purified. CAS No. 2259-96-3. Pack Sizes: 50mg. Molecular Formula: C??H??ClN?O?S?, Molecular Weight: 389.88. US Biological Life Sciences. |  Worldwide |
| 2-Amino-5-chloro Benzene sulfonamide | 2-Amino-5-chloro Benzene sulfonamide is a metabolite of IDRA-21 (I232500), which inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960). Group: Biochemicals. Grades: Highly Purified. CAS No. 5790-69-2. Pack Sizes: 500mg, 2.5g. Molecular Formula: C6H7ClN2O2S, Molecular Weight: 206.65. US Biological Life Sciences. | Worldwide |
| AMPA Agonist, CMPA (AMPA Activator, N,N-(2,2-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide) | A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45nM and 63nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10uM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 376.5. US Biological Life Sciences. | Worldwide |
| IDRA-21 | IDRA-21, an analog of cyclothiazide, inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. Synonyms: 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide; IDRA-21; IDRA 21; IDRA21. CAS No. 22503-72-6. Molecular formula: C8H9ClN2O2S. Mole weight: 232.68. | |
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