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| Product | Description | |
|---|---|---|
| [1(S)-Phenylethoxy]-Aprepitant | [1(S)-Phenylethoxy]-Aprepitant is a derivative of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Group: Biochemicals. Grades: Highly Purified. CAS No. 170902-81-5. Pack Sizes: 1mg, 10mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences. |  Worldwide |
| (2R,3R,1S)-Aprepitant | (2R,3R,1S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1242175-34-3. Pack Sizes: 1mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences. | Worldwide |
| (2S,3R,1R)-Aprepitant | (2S,3R,1R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1185502-97-9. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences. | Worldwide |
| (2S,3S,1R)-Aprepitant | (2S,3S,1R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs. Group: Biochemicals. Grades: Highly Purified. CAS No. 172822-28-5. Pack Sizes: 1mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences. | Worldwide |
| 4'-Hydroxy diclofenac | 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 64118-84-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15550. |  |
| 4-Hydroxytolbutamide | 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hydroxytolbutamide. CAS No. 5719-85-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-100641. | |
| Apigenin | Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a K i of 2 μM. Uses: Scientific research. Group: Natural products. Alternative Names: 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1. CAS No. 520-36-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N1201. | |
| Asebogenin | Asebogenin is extracted from the leaves of Pieris japonica. It can inhibit the proliferation of murine B cells. It displays antiplasmodial activities against both a resistant strain and a chloroquine-sensitive of Plasmodium falciparum. It also shows anti-bacterial activity. It inhibits methicillin-resistant S. aureus and S. aureus with IC50 values of 4.5 and 10 micrograms/ml respectively. It is a predicted metabolite generated by BioTransformer. It is generated through an o-dealkylation reaction, which occurs in humans and is generated by cyp1a2, cyp2c9 and cyp2c19 enzymes. Synonyms: 4'-O-Methylphloretin; 1-(2,6-Dihydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-1-propanone. Grade: 98%. CAS No. 520-42-3. Molecular formula: C16H16O5. Mole weight: 288.29. |  |
| Baicalein | Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. Baicalein is a natural compound and can be used in cosmestics material. Uses: Neuroprotective; anticancer. Synonyms: 5,6,7-Trihydroxyflavone; 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one; NSC 661431; Noroxylin; 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one. Grade: ≥98%. CAS No. 491-67-8. Molecular formula: C15H10O5. Mole weight: 270.24. | |
| Benzbromarone | Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM. Uses: Uricosuric agents. Synonyms: L2214; L 2214; L-2214; L2214-Labaz; MJ 10061; Narcaricin; Normurat; Benzbromarone. Grade: >98%. CAS No. 3562-84-3. Molecular formula: C17H12Br2O3. Mole weight: 424.08. | |
| Cedrol | Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, insecticidal, and anti-fungal activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cypress camphor. Product Category: Inhibitors. Appearance: Pale yellow to yellow green solid. CAS No. 77-53-2. Molecular formula: C15H26O. Mole weight: 222.37. Purity: 0.99. IUPACName: (1S,2R,5S,7R,8R)-2,6,6,8-Tetramethyltricyclo[5.3.1.01,5]undecan-8-ol. Canonical SMILES: CC1CCC2C13CCC(C(C3)C2(C)C)(C)O. Density: 0.9479 g/cm³. Product ID: ACM77532. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Cepharanthine | Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration ( IC 50 ) and 90% inhibitory concentration ( IC 90 ) values of 1.90 and 4.46?μM [1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model [2] [3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 481-49-2. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-N6972. | |
| DMU2139 | DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively. DMU2139 showed a very high level of selectivity towards CYP1B1 with respect to the IC50 values obtained with CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2C9 and CYP2C19 Sacchrosomes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DMU2139; DMU-2139; DMU 2139. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1821143-80-9. Molecular formula: C19H15NO2. Mole weight: 289.33. Purity: >98%. IUPACName: (E)-1-(6-methoxynaphthalen-2-yl)-3-(pyridin-3-yl)prop-2-en-1-one. Canonical SMILES: O=C(C1=CC=C2C=C(OC)C=CC2=C1)/C=C/C3=CC=CN=C3. Product ID: ACM1821143809. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fenofibrate | Fenofibrate is a selective PPARα agonist with an EC 50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC 50 s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19 , CYP2B6 , CYP2C9 , CYP2C8 , and CYP3A4 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 49562-28-9. Pack Sizes: 10 mM * 1 mL; 200 mg; 5 g; 10 g. Product ID: HY-17356. | |
| Fenofibrate (Standard) | Fenofibrate (Standard) is the analytical standard of Fenofibrate. This product is intended for research and analytical applications. Fenofibrate is a selective PPARα agonist with an EC 50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC 50 s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19 , CYP2B6 , CYP2C9 , CYP2C8 , and CYP3A4 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 49562-28-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-17356R. | |
| Gemfibrozil | Gemfibrozil is an activator of PPAR-α , used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with K i values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-719. CAS No. 25812-30-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0258. | |
| Ginsenoside C-K | Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 ?M and 63.6±4.2 ?M, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Ginsenoside compound K; Ginsenoside K. CAS No. 39262-14-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0904. | |
| Ginsenoside Rd | Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC 50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca 2+ influx. Ginsenoside Rd inhibits CYP2D6 , CYP1A2 , CYP3A4 , and CYP2C9 , with IC 50 s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Gypenoside VIII. CAS No. 52705-93-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0043. | |
| Hyperforin DCHA | Key constituent of St. John's wort. Shows properties of potential pharmacological interest, including anti-bacterial, anti-malarial, anti-inflammatory, anti-cancer and anti-angiogenic effects. Anti-depressant and anxiolytic compound. Specific activator of TRPC6 channels. Inhibits the re-uptake of neurotransmitters in synapses (serotonin, norepinephrine, dopamine, GABA, glutamate). Activator of the pregnane X receptor (PXR). Regulates expression of the cytochrome P450 CYP3A4 and CYP2C9 and hepatic drugs metabolism. Potential anti-Alzheimer compound. Potent SIRT1 (sirtuin 1) and SIRT2 (sirtuin 2) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 238074-03-8. Pack Sizes: 500ug, 1mg. Molecular Formula: C35H51O4 C12H24N. US Biological Life Sciences. | Worldwide |
| Hyperforin DCHA (5-hydroxy-6R-methyl-1R, 3, 7S-tris(3-methyl-2-butenyl)-5S-(2-methyl-1-oxopropyl)-6R-(4-methyl-3-pentenyl)-bicyclo[3.3.1]non-3-ene-2,9-dione, DHCA) | Displays a variety of biological activities including anti-bacterial, anti-inflammatory, anticancer and anti-angiogenic effects. Also acts as an antidepressant and anxiolytic agent. Regulates expression of the cytochrome P450 CYP3A4 and CYP2C9 and hepatic drugs metabolism. Inhibits the re-uptake of neurotransmitters in synapses (serotonin, norepinephrine, dopamine, GABA, glutamate). Also acts as a potent SIRT1 and SIRT2 inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 238074-03-8. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| IDO1-IN-19 | IDO1-IN-19 (Compound 17) is an orally active IDO1 inhibitor with an IC 50 of CYP2C9 of 8.64 μM. IDO1-IN-19 also acts funciton on cardiac channels, with IC 50 s of 12 μM ( IKr ), 40 μM ( INa ), 8.3 μM ( ICa ), respectively. IDO1-IN-19 has the potential to study cancer diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2328099-11-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144652. | |
| N-Hydroxy-N- (4-butyl-2-methylphenyl) formamidine (HET-0016) | HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other CYPs: CYP2C9-3.3uM, CYP2D6=83. Group: Biochemicals. Alternative Names: HET-0016. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Pioglitazone hydrochloride | Pioglitazone hydrochloride, a thiazolidinedione antidiabetic drug, is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor with Kis of 1.7, 11.8 and 32.1 μM for CYP2C8, CYP3A4 and CYP2C9, respectively. It is an agonist of the peroxisome proliferator-activated receptor γ. Uses: Hypoglycemic agents. Synonyms: 5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione Hydrochloride; AD-4833; Actos; U-72107A; 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride; NSC 758876; 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-, monohydrochloride. Grade: >98%. CAS No. 112529-15-4. Molecular formula: C19H20N2O3S.HCl. Mole weight: 392.90. | |
| Ranitidine | Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC 50 of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of CYP2C19 and CYP2C9 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66357-35-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0693. | |
| Ranitidine-d6 hydrochloride | Ranitidine-d 6 (hydrochloride) is the deuterium labeled Ranitidine hydrochloride. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1185238-09-8. Pack Sizes: 1 mg. Product ID: HY-B0281AS. | |
| Ranitidine hydrochloride | Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC 50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66357-59-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0281A. | |
| Sulfaphenazole | Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial. Uses: Designed for use in research and industrial production. Additional or Alternative Names: LABOTEST-BB LT00772280;4-AMINO-N-(1-PHENYL-1H-PYRAZOL-5-YL)BENZENESULFONAMIDE;1-Phenyl-5-sulfanilamidopyrazole;3-(p-Aminobenzenesulfonamido)-2-pheny-2H-lpyrazole;3-(p-aminobenzenesulfonamido)-2-phenylpyrazole;4-amino-n-(1-phenyl-1h-pyrazol-5-yl)-benzenesulfonamid;5-Sulfanilamido-1-phenylpyrazole;Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-. Product Category: Inhibitors. Appearance: Solid. CAS No. 526-08-9. Molecular formula: C15H14N4O2S. Mole weight: 314.36. Purity: 0.9983. Canonical SMILES: O=S(C1=CC=C(N)C=C1)(NC2=CC=NN2C3=CC=CC=C3)=O. Density: 1.39. Product ID: ACM526089. Alfa Chemistry ISO 9001:2015 Certified. | |
| Sulfaphenazole-[13C6] | Sulfaphenazole-[13C6] is the labelled analogue of Sulfaphenazole, which is an inhibitor of CYP2C9 with antibacterial and antimicrobial activity. Synonyms: Sulfaphenazole-13C6; Depocid-13C6; 4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-benzene-13C6-sulfonamide; Sulfaphenazole-(sulfanilamide ring-13C6); 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide-13C6; N1-(1-Phenylpyrazol-5-yl)sulfanilamidopyrazole-13C6; 2-Phenyl-3-sulfanilamidopyrazole-13C6; 3-(p-Aminobenzenesulfonamido)-2-phenylpyrazole-13C6; 5-Sulfanilamido-1-phenylpyrazole-13C6. Grade: 95% by HPLC; 98% atom 13C. CAS No. 1420043-53-3. Molecular formula: C9[13C]6H14N4O2S. Mole weight: 320.32. | |
| Tankyrase1/2 Inhibitor III (TNKS1/2 Inhibitor III, Wnt Pathway Inhibitor XIV, 3-(4-Methoxyphenyl)-5-((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-ylthio)methyl)-1,2,4-oxadiazole) | A cell-permeable triazolylthiomethyl-oxadiazole compound that binds TNKS1/PARP5a and TNKS2/PARP5b with high affinity (=79 and 28nM, respectively), and acts as a potent and reversible TNKS1/2 dual inhibitor (IC50=33nM TNKS2 in an auto-PARsylation assay). Shown to interact with the adenosine diphosphate linker portion of the NAD+ donor site, and display excellent selectivity over PARP1 and PARP2 activities (IC50>19uM); stabilize Axin2 levels (EC50=709nM in SW480 cells), and antagonize Wnt signaling (IC50=215nM in HEK293-SuperTopFlash assay). Exhibits minimal activity towards cytochrome P450 enzymes (IC50=21 and 5.7uM for CYP2C9 and CYP3A4) and hERG ion channel (IC50>30uM), and adequate microsomal stability. Group: Biochemicals. Grades: Highly Purified. CAS No. 865565-29-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Tetrahydrocurcumin | Tetrahydrocurcumin is a Curcuminoid found in turmeric ( Curcuma longa ) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4. Uses: Scientific research. Group: Natural products. Alternative Names: HZIV 81-2. CAS No. 36062-04-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0893. | |
| Tetrahydrocurcumin (Standard) | Tetrahydrocurcumin (Standard) is the analytical standard of Tetrahydrocurcumin. This product is intended for research and analytical applications. Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4. Uses: Scientific research. Group: Natural products. CAS No. 36062-04-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0893R. | |
| Ticlopidine | Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCR 5332. CAS No. 55142-85-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100386. | |
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