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| Product | Description | |
|---|---|---|
| cystathionine β-lyase | A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-homocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds. Possibly identical, in yeast, with EC 4.4.1.6 S-alkylcysteine lyase. Group: Enzymes. Synonyms: β-cystathionase; cystine lyase; cystathionine L-homocysteine-lyase (deaminating); L-cystathionine L-homocysteine-lyase (deaminating); CBL. Enzyme Commission Number: EC 4.4.1.8. CAS No. 9055-5-4. Cystathionine β-lyase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5341; cystathionine β-lyase; EC 4.4.1.8; 9055-05-4; β-cystathionase; cystine lyase; cystathionine L-homocysteine-lyase (deaminating); L-cystathionine L-homocysteine-lyase (deaminating); CBL. Cat No: EXWM-5341. |  |
| Cystathionine β-lyase, Recombinant | In enzymology, a cystathionine beta-lyase (EC 4.4.1.8) is an enzyme that catalyzes the chemical reaction: L-cystathionine + H2O ? L-homocysteine + NH3 + pyruvate. Thus, the two substrates of this enzyme are L-cystathionine and H2O, whereas its 3 products are L-homocysteine, NH3, and pyruvate. This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. Applications: This protein can be used for producing hcy in vitro diagnosis kit. Group: Enzymes. Synonyms: L-cystathionineL-homocysteine-lyase (deaminating; pyruvate-forming); beta-cystathionase; cystine lyase; cystathionine L-homocysteine-lyase (deaminating); L-cystathionineL-homoc. Enzyme Commission Number: EC 4.4.1.8. Purity: >90% (by SDS-PAGE). Mole weight: 43KD. Activity: >500U/mg. Appearance: Lyophilized powder. Storage: The lyophilized powder should be stored at -20°C where it is stable for up to several years. The solution could be stored at 4°C where it is stable for up to 1 year. Repeated freezing and thawing cycles of the reconstituted solution is not recommended. Form: Freeze dried powder. L-cystathionineL-homocysteine-lyase (deaminating; pyruvate-forming); beta-cystathionase; cystine lyase; cystathionine L-homocysteine-lyase (deaminating); L-cystathionineL-homocysteine-lyase (deaminating); Cystathionine β-lyase; EC 4.4.1.8. Cat No: NATE-1146. | |
| Cystathionine β-lyase, Recombinant Microorganisms | Cystathionine β-lyase, Recombinant Microorganisms (CBL) is an enzyme that catalyzes the breakdown of cystathionine to homocysteine, the penultimate step in methionine biosynthesis. Cystathionine β-lyase is important for bacterial virulence [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CBL. CAS No. 9055-5-4. Pack Sizes: 100 U; 500 U. Product ID: HY-E70079. |  |
| cystathionine γ-lyase | A multifunctional pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses the conversion of L-homoserine to 2-oxobutanoate and ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of L-cysteine to pyruvate, hydrogen sulfide and ammonia. Group: Enzymes. Synonyms: homoserine deaminase; homoserine dehydratase; cystine desulfhydrase; cysteine desulfhydrase; γ-cystathionase; cystathionase; homoserine deaminase-cystathionase; γ-CTL; cystalysin; cysteine lyase; L-cystathionine cysteine-. Enzyme Commission Number: EC 4.4.1.1. CAS No. 9012-96-8. CGL. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5312; cystathionine γ-lyase; EC 4.4.1.1; 9012-96-8; homoserine deaminase; homoserine dehydratase; cystine desulfhydrase; cysteine desulfhydrase; γ-cystathionase; cystathionase; homoserine deaminase-cystathionase; γ-CTL; cystalysin; cysteine lyase; L-cystathionine cysteine-lyase (deaminating); CGL. Cat No: EXWM-5312. | |
| Cystathionine gamma-lyase, Recombinant | Cystathionine gamma-lyase (CGL),or cystathionase (CSE, EC 4.4.1.1) , the enzyme participating in the synthesis of cysteine, catalyzes cystathionine deamination action, and form cysteine, alpha ketone butyric acid and NH3. In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide. Hydrogen sulfide is one of a few gases that was recently discovered to have arole in cell signaling in the body. As a new gaseous signal molecular, h2s has the similar but different mechanisms with carbon monoxide (co), nitric oxide (no) in diastolic function forblood vessels, which has several function such as the proliferation of vascular smooth muscle...e; CGL; cystathionase; CSE; EC 4.4.1.1; homoserine deaminase; homoserine dehydratase; cystine desulfhydrase; cysteine desulfhydrase; γ-cystathionase; cystathionase; homoserine deaminase-cystathionase; γ-CTL; cystalysin; cysteine lyase; L-cystathionine cysteine-lyase (deaminating); cystathionine γ-lyase. Enzyme Commission Number: EC 4.4.1.1. Purity: >90% (SDS-PAGE test). Mole weight: About 44kDa (SDS-PAGE detection). Activity: 11.25 KU/mg protein. Appearance: Yellowish liquid (or lyophilized powder). Storage: 4°C, store at -20°C for long-term preservation. Form: Freeze dried powder. Cystathionine gamma-lyase; CGL; cystathionase; CSE; EC 4.4.1.1; homoserine | |
| 7-Azido-4-methylcoumarin (AzMC) | Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4- methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex=365nm and lambdaem=450nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). Probe to monitor the enzymatic production of H2S in vitro and to visualize H2S in living cells. Tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)). Tool to identify novel cystathionine beta-synthase (CBS) inhibitors and activators. Suitable for high-throughput screening. Use of this product with DTT, TCEP and/or biological thiols at concentrations of >25mM should be avoided for maximum efficiency. Group: Biochemicals. Grades: Highly Purified. CAS No. 95633-27-5. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. |  Worldwide |
| Aminoethoxyvinyl glycine Hydrochloride (ABG 3168) | Ethylene, an important plant regulator, is synthesized from S-adenosyl-L-methionine by the sequential action of 1-amino-cyclopropane-carboxylate (ACC) synthases (ACSs) and ACC oxidases (ACOs). Aminoethoxyvinyl glycine is an inhibitor of ethylene biosynthesis that, at 1uM, blocks the activity of both ACSs and ACOs.1 Through this action, it reduces ethylene-mediated changes in plant growth and development.2,3,4 Aminoethoxyvinyl glycine also inhibits cystathionine γ-lyase (Ki = 10.5uM) with slow- and tight-binding characteristics.5. Group: Biochemicals. Alternative Names: (2S,3E)-2-Amino-4-(2-aminoethoxy)-3-butenoic Acid Monohydrochloride; [S-(E)]-2-Amino-4-(2-aminoethoxy)-3-butenoic Acid Monohydrochloride; (S)-trans-2-Amino-4-(2-aminoethoxy)-3-butenoic Acid Hydrochloride; ABG 3168 Hydrochloride; L-2-Amino-4-(2'-aminoethoxy)-trans-3-butenoic Acid Hydrochloride; ReTain Hydrochloride; ReTain (plant growth regulator) Hydrochloride. Grades: Highly Purified. CAS No. 55720-26-8. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C?H??ClN?O?, Molecular Weight: 196.63. US Biological Life Sciences. | Worldwide |
| Aurintricarboxylic acid | Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs , with IC 50 s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively [1]. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase [2]. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis [3]. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway [4]. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC 50 of 0.6 μM [5]. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC 50 of 0.47 μM [6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4431-00-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-122575. | |
| Aurintricarboxylic Acid | Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 μM. Group: Inhibitors. Alternative Names: Ata. CAS No. 4431-00-9. Molecular formula: C22H14O9. Mole weight: 422.34. Appearance: Powder. Purity: 0.85. Canonical SMILES: C1=CC (=C (C=C1C (=C2C=CC (=O)C (=C2)C (=O)O)C3=CC (=C (C=C3)O)C (=O)O)C (=O)O)O. Catalog: ACM4431009. |  |
| cystathionine β-synthase | A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses β-replacement reactions between L-serine, L-cysteine, cysteine thioethers, or some other β-substituted α-L-amino acids, and a variety of mercaptans. Group: Enzymes. Synonyms: serine sulfhydrase; β-thionase; methylcysteine synthase; cysteine synthase (incorrect); serine sulfhydrylase; L-serine hydro-lyase (adding homocysteine). Enzyme Commission Number: EC 4.2.1.22. CAS No. 9023-99-8. CBS. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5015; cystathionine β-synthase; EC 4.2.1.22; 9023-99-8; serine sulfhydrase; β-thionase; methylcysteine synthase; cysteine synthase (incorrect); serine sulfhydrylase; L-serine hydro-lyase (adding homocysteine). Cat No: EXWM-5015. | |
| Cystathionine β Synthase from Human, recombinant | Cystathionine-β-synthase, also known as CBS, is an enzyme (EC 4.2.1.22) that in humans is encoded by the CBS gene. CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet). This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds. CBS is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The CBS gene is the most common locus for mutations associated with homocystinuria. Group: Enzymes. Synonyms: Cystathionine-β-synthase; CBS; EC 4.2.1.22; 9023-99-8; Cystathionine β-synthase; Beta-thionase; methylcysteine synthase; serine sulfhydrase. Enzyme Commission Number: EC 4.2.1.22. Purity: > 90% by SDS-PAGE. CBS. Mole weight: 61.9 kDa (1-551 aa, NT His Tag). Activity: 100 U/mg. Stability: Stable for at least 1 year as supplied. Avoid repeated freeze and thaw cycles. Storage: Store at -20°C. Form: Liquid. Source: E. coli. Species: Human. Cystathionine-β-synthase; CBS; EC 4.2.1.22; 9023-99-8; Cystathionine β-synthase; Cystathionine β synthase; Beta-thionase; methylcysteine synthase; serine sulfhydrase. Cat No: NATE-1667. | |
| Cystathionine-β-synthase, Recombinant | Cystathionine-β-synthase, also known as CBS, is an enzyme (EC 4.2.1.22) that in humans is encoded by the CBS gene. CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet). This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds. CBS is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The CBS gene is the most common locus for mutations associated with homocystinuria. Applications: This protein can be used for producing hcy in vitro diagnosis kit. Group: Enzymes. Synonyms: Cystathionine-β-synthase; CBS; EC 4.2.1.22; 9023-99-8. Enzyme Commission Number: EC 4.2.1.22. CAS No. 9023-99-8. Purity: >90% (by SDS-PAGE). CBS. Mole weight: 56 KD. Appearance: Lyophilized powder. Storage: The lyophilized powder should be stored at -20°C where it is stable for up to several years. The solution could be stored at 4°C where it is stable for up to 1 year. Repeated freezing and thawing cycles of the reconstituted solution is not recommended. Cystathionine-β-synthase; CBS; EC 4.2.1.22; 9023-99-8. Cat No: DIA-293. | |
| cystathionine γ-synthase | A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse β,γ-elimination to form 2-oxobutanoate, succinate and ammonia. Group: Enzymes. Synonyms: O-succinyl-L-homoserine succinate-lyase (adding cysteine); O-succinylhomoserine (thiol)-lyase; homoserine O-transsuccinylase; O-succinylhomoserine synthase; O-succinylhomoserine synthetase; cystathionine synthase; cystathionine synthetase; homoserine transsuccinylase; 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase. Enzyme Commission Number: EC 2.5.1.48. CAS No. 9030-70-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2784; cystathionine γ-synthase; EC 2.5.1.48; 9030-70-0; O-succinyl-L-homoserine succinate-lyase (adding cysteine); O-succinylhomoserine (thiol)-lyase; homoserine O-transsuccinylase; O-succinylhomoserine synthase; O-succinylhomoserine synthetase; cystathionine synthase; cystathionine synthetase; homoserine transsuccinylase; 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase. Cat No: EXWM-2784. | |
| DL-Propargyl glycine hydrochloride | DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 μM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock. Synonyms: PAG; 2-Aminopent-4-ynoic acid hydrochloride; AK323755; AK110719. Grades: ≥95%. CAS No. 16900-57-5. Molecular formula: C5H7NO2·HCl. Mole weight: 149.6. |  |
| L-cysteine desulfidase | The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster and is specific for L-cysteine (cf. EC 4.4.1.1, cystathionine γ-lyase). It cleaves a carbon-sulfur bond releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The same reaction can also be catalysed by some pyridoxal-phosphate proteins (cf. EC 4.4.1.1, cystathionine γ-lyase). Group: Enzymes. Synonyms: L-cysteine desulfhydrase. Enzyme Commission Number: EC 4.4.1.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5330; L-cysteine desulfidase; EC 4.4.1.28; L-cysteine desulfhydrase. Cat No: EXWM-5330. | |
| L-Propargylglycine | It is produced by the strain of Streptomyces sp. It can inactivate many vitamin B6-enzymes, such as Cystathionine γ-synthase, Methionone γ-lyase and L-alanine aminotransferase. Synonyms: (S)-2-Aminopent-4-ynoic acid; (S)-2-Amino-4-pentynoic acid; L-2-Propynylglycine; (S)-Propargylglycine; (S)-2-Propargylglycine; L-Pra-OH; L-Propargyl-Gly-OH; 4-Pentynoic acid, 2-amino-, (2S)-; (2S)-2-Amino-4-pentynoic acid; 4-Pentynoic acid, 2-amino-, (S)-; 4-Pentynoic acid, 2-amino-, L-; (2S)-2-Azaniumylpent-4-ynoate; (S)-α-Propargylglycine; L-2-Amino-4-pentynoic acid. Grades: ≥95%. CAS No. 23235-01-0. Molecular formula: C5H7NO2. Mole weight: 113.11. | |
| Native Cystathionine-β-synthase | Cystathionine-β-synthase, also known as CBS, is an enzyme (EC 4.2.1.22) that in humans is encoded by the CBS gene. CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet). This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds. CBS is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The CBS gene is the most common locus for mutations associated with homocystinuria. Human cbs performs a crucial step in the biosynthetic pathway of cysteine by providing a regulatory control po...nates methyl groups to a variety of substrates, e.g., neurotransmitters, proteins, and nucleic acids. in mammals, cbs is a highly regulated enzyme, which contains a heme cofactor that functions as a redox sensor, that can modulate its activity in response to changes in the redox potential. if the resting form of cbs in the cell has ferrous heme, the potential exists for activating the enzyme under oxidizing conditions by conversion to the ferric state. Group: Enzymes. Synonyms: Cystathionine-β-synthase; CBS; EC 4.2.1.22; 9023-99-8. Enzyme Commission Number: EC 4.2.1.22. CAS No. 9023-99-8. CBS. Cystathionine-β-synthase; CBS; EC 4.2.1.22; 9023-99-8. Cat No: DIA-272. | |
| S-alkylcysteine lyase | A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing an alkyl thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Possibly identical, in yeast, with EC 4.4.1.8 cystathionine β-lyase. Group: Enzymes. Synonyms: S-alkylcysteinase; alkylcysteine lyase; S-alkyl-L-cysteine sulfoxide lyase; S-alkyl-L-cysteine lyase; S-alkyl-L-cysteinase; alkyl cysteine lyase; S-alkyl-L-cysteine alkylthiol-lyase (deaminating). Enzyme Commission Number: EC 4.4.1.6. CAS No. 62213-27-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5340; S-alkylcysteine lyase; EC 4.4.1.6; 62213-27-8; S-alkylcysteinase; alkylcysteine lyase; S-alkyl-L-cysteine sulfoxide lyase; S-alkyl-L-cysteine lyase; S-alkyl-L-cysteinase; alkyl cysteine lyase; S-alkyl-L-cysteine alkylthiol-lyase (deaminating). Cat No: EXWM-5340. | |
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