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| Product | Description | |
|---|---|---|
| cytidine deaminase | Contains zinc. Catalyses the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Group: Enzymes. Synonyms: cytosine nucleoside deaminase; (deoxy)cytidine deaminase; cdd (gene name); CDA (gene name). Enzyme Commission Number: EC 3.5.4.5. CAS No. 9025-6-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4573; cytidine deaminase; EC 3.5.4.5; 9025-06-3; cytosine nucleoside deaminase; (deoxy)cytidine deaminase; cdd (gene name); CDA (gene name). Cat No: EXWM-4573. |  |
| Cytidine deaminase from Human, recombinant | CDA (Cytidine deaminase) is an enzyme that scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. This protein is one of several deaminases responsible for maintaining the cellular pyrimidine pool. The protein also catalyzes the deamination of chemotherapeutic cytosine nucleoside analogs such as Ara-C and 5-azacytidine, which results in the loss of their cytotoxic and antitumor function. It can form homotetramers and is mainly expressed in granulocytes. Recombinant human CDA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Group: Enzymes. Synonyms: CDA; CDD; Cytidine aminohydrolase; Cytosine nucleoside deaminase. Enzyme Commission Number: EC 3.5.4.5. Purity: > 90% by SDS-PAGE. Mole weight: 18.3 kDa (166 aa, 1-146 aa + His Tag). Activity: > 3.5 unit/mg. Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: E. coli. Species: Human. CDA; CDD; Cytidine aminohydrolase; Cytosine nucleoside deaminase; Cytidine deaminase. Cat No: NATE-1668. | |
| 2'-?Deoxy-?3'-?O-?[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?-?N, ?5-?dimethyl-cytidine | 2'-?Deoxy-?3'-?O-?[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?-?N, ?5-?dimethyl-cytidine is an intermediate in synthesizing N4,5-Dimethyldeoxycytidine (D468100), which has been shown to participate in cytidine deaminase inhibition. Group: Biochemicals. Grades: Highly Purified. CAS No. 1569273-35-3. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C17H31N3O4Si. US Biological Life Sciences. |  Worldwide |
| 2'-?Deoxy-?3'-?O-?[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?-?N, ?5-?dimethyl-cytidine | 2'-Deoxy-3'-O-[(1,?1-dimethylethyl)?dimethylsilyl]?-N,?5-dimethyl-cytidine is an intermediate in synthesizing N4,5-Dimethyldeoxycytidine, which has been shown to participate in cytidine deaminase inhibition. CAS No. 1569273-35-3. Molecular formula: C17H31N3O4Si. Mole weight: 369.53. |  |
| 3,4,5,6-Tetrahydrouridine (THU) | 3,4,5,6-Tetrahydrouridine, a derivative of Uridine, is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. Group: Biochemicals. Alternative Names: Tetrahydro-4-hydroxy-1- β-D-ribofuranosyl-2(1H)-pyrimidinone; 1-( β-D-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone; NSC 112907; Tetrahydrouridine. Grades: Purified. CAS No. 18771-50-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C?H??N?O?. US Biological Life Sciences. | Worldwide |
| 3',5'-Bis-O-t-Butyldimethylsilyl N4,5-Dimethyldeoxycytidine | 3',5'-Bis-O-t-Butyldimethylsilyl N4,5-Dimethyldeoxycytidine is an intermediate in synthesizing N4,5-Dimethyldeoxycytidine, which has been shown to participate in cytidine deaminase inhibition. CAS No. 2062540-26-3. Molecular formula: C23H45N3O4Si2. Mole weight: 483.79. | |
| 5,6-Dihydrouridine | 5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%), which is a derivative of Uridine. Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. Synonyms: Dihydro-1-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione; Dihydrouridine; 1-β-D-Ribofuranosyl-hydrouracil; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(β-L-Ribofuranosyl)dihydro-2,4(1H,3H)-pyrimidinedione. Grades: ≥95%. CAS No. 5627-5-4. Molecular formula: C9H14N2O6. Mole weight: 246.22. | |
| Cedazuridine | Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC 50 value of 0.4 μM. Cedazuridine can be used for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E7727. CAS No. 1141397-80-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109081. |  |
| Elacytarabine | Elacytarabine (CP-4055) is the lipophilic 5'-elaidic acid ester of the deoxycytidine analog cytosine arabinoside (cytarabine; Ara-C) with potential antineoplastic activity. As a prodrug, CP-4055 is converted intracellularly into cytarabine triphosphate by deoxycytidine kinase and subsequently competes with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis. Compared to cytarabine, CP-4055 shows increased cellular uptake and retention, resulting in increased activation by deoxycytidine kinase to cytarabine triphosphate, decreased deamination and deactivation by deoxycytidine deaminase, and increased inhibition of DNA synthesis. This agent also inhibits RNA synthesis, an effect not seen with cytarabine. Synonyms: CP-4055; CP 4055; CP4055; 5'-O-(Elaidoyl) 1-beta-D-arabinofuranosylcytosine; 5'-Oleoyl cytarabine; (E)-((2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate. CAS No. 188181-42-2. Molecular formula: C27H45N3O6. Mole weight: 507.67. | |
| mRNA(cytosine6666) deaminase | The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site. Group: Enzymes. Synonyms: APOBEC-1 (catalytic component of an RNA-editing complex); APOBEC1 (catalytic subunit); apolipoprotein B mRNA-editing enzyme 1 (catalytic component of an RNA-editing complex); apoB mRNA-editing enzyme catalytic polypeptide 1 (catalytic component of an RNA-editing complex); apoB mRNA editing complex; apolipoprotein B mRNA editing enzyme; REPR. Enzyme Commission Number: EC 3.5.4.36. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4564; mRNA(cytosine6666) deaminase; EC 3.5.4.36; APOBEC-1 (catalytic component of an RNA-editing complex); APOBEC1 (catalytic subunit); apolipoprotein B mRNA-editing enzyme 1 (catalytic component of an RNA-editing complex); apoB mRNA-editing enzyme catalytic polypeptide 1 (catalytic component of an RNA-editing complex); apoB mRNA editing complex; apolipoprotein B mRNA editing enzyme; REPR. Cat No: EXWM-4564. | |
| SGI-110 | SGI-110 is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. Uses: Antineoplastic agents. Synonyms: Guadecitabine; SGI 110; SGI110; 2'-deoxy-5-azacytidylyl-(3'->5')-2'-deoxyguanosine; (2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl (((2R,3S,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) hydrogen phosphate. Grades: ≥95%. CAS No. 929901-49-5. Molecular formula: C18H24N9O10P. Mole weight: 557.41. | |
| single-stranded DNA cytosine deaminase | The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G). The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences. Group: Enzymes. Synonyms: AID; activation-induced deaminase; AICDA (gene name); activation-induced cytidine deaminase. Enzyme Commission Number: EC 3.5.4.38. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4566; single-stranded DNA cytosine deaminase; EC 3.5.4.38; AID; activation-induced deaminase; AICDA (gene name); activation-induced cytidine deaminase. Cat No: EXWM-4566. | |
| Tetrahydrouridine | Tetrahydrouridine, a derivative of Uridine, is a potent and reversible competitive inhibitor of cytidine deaminase (CDD) (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively). Tetrahydrouridine has the potential to treat tumors with highly expressed CDA as it inhibits cell proliferation through cell cycle regulation despite of cytidine deaminase expression levels deaminase (CDA). Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. Uses: Antimetabolites. Synonyms: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one; NSC 112907; Tetrahydrouridine, NSC 112907; NSC-112907; NSC112907. Grades: 95%. CAS No. 18771-50-1. Molecular formula: C9H16N2O6. Mole weight: 248.23. | |
| Tetrahydrouridine | Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase ( CDA ), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: THU; NSC-112907. CAS No. 18771-50-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-15345A. | |
| Tezacitabine | Tezacitabine is a synthetic purine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, further compromising DNA replication. This agent is relatively resistant to metabolic deactivation by cytidine deaminase. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates necessary for DNA synthesis and is overexpressed in many tumor types. Uses: Enzyme inhibitors. Synonyms: MDL 101731; FMdC; KW 2331; MDL 101731; KW2331; MDL101731; Tezacitabine; MDL 101,731; FMdC. CAS No. 130306-02-4. Molecular formula: C10H12FN3O4. Mole weight: 257.221. | |
| Zebularine | It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent. Group: Biochemicals. Alternative Names: 1- β-D-Ribofuranosyl-. Grades: Highly Purified. CAS No. 3690-10-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Zebularine | Zebularine is a nucleoside analogue of cytidine. It is a transition state analogue inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. It can inhibit DNA methylation and tumor growth in vitro and in vivo. Synonyms: 1-b-D-Ribofuranosyl-2-(1H)-pyrimidinone; 4-Deoxyuridine; NSC 309132; NSC309132; NSC-309132; Pyrimidin-2-one β-D-Ribofuranoside; 1-beta-D-ribofuranosylpyrimidin-2(1H)-one; 2-Pyrimidone-1-beta-D-riboside; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one. Grades: ≥95%. CAS No. 3690-10-6. Molecular formula: C9H12N2O5. Mole weight: 228.20. | |
| Zebularine | Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor. Zebularine also inhibits cytidine deaminase with a K i of 0.95 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC309132; 4-Deoxyuridine. CAS No. 3690-10-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13420. | |
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