Cytidine Deaminase Suppliers USA
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Product | Description | |
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2'-?Deoxy-?3'-?O-?[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?-?N, ?5-?dimethyl-cytidine Quick inquiry Where to buy Suppliers range | 2'-?Deoxy-?3'-?O-?[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?-?N, ?5-?dimethyl-cytidine is an intermediate in synthesizing N4,5-Dimethyldeoxycytidine (D468100), which has been shown to participate in cytidine deaminase inhibition. Group: Biochemicals. Grades: Highly Purified. CAS No. 1569273-35-3. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C17H31N3O4Si. US Biological Life Sciences. | Worldwide |
2'-?Deoxy-?3'-?O-?[(1,?1-?dimethylethyl)?dimethylsilyl]?-?N,?5-?dimethyl-cytidine Quick inquiry Where to buy Suppliers range | 2'-Deoxy-3'-O-[(1,?1-dimethylethyl)?dimethylsilyl]?-N,?5-dimethyl-cytidine is an intermediate in synthesizing N4,5-Dimethyldeoxycytidine, which has been shown to participate in cytidine deaminase inhibition. CAS No. 1569273-35-3. Molecular formula: C17H31N3O4Si. Mole weight: 369.53. | |
3,4,5,6-Tetrahydrouridine (THU) Quick inquiry Where to buy Suppliers range | 3,4,5,6-Tetrahydrouridine, a derivative of Uridine, is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. Group: Biochemicals. Alternative Names: Tetrahydro-4-hydroxy-1- β-D-ribofuranosyl-2(1H)-pyrimidinone; 1-( β-D-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone; NSC 112907; Tetrahydrouridine. Grades: Purified. CAS No. 18771-50-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C?H??N?O?. US Biological Life Sciences. | Worldwide |
3',5'-Bis-O-t-Butyldimethylsilyl N4,5-Dimethyldeoxycytidine Quick inquiry Where to buy Suppliers range | 3',5'-Bis-O-t-Butyldimethylsilyl N4,5-Dimethyldeoxycytidine is an intermediate in synthesizing N4,5-Dimethyldeoxycytidine, which has been shown to participate in cytidine deaminase inhibition. CAS No. 2062540-26-3. Molecular formula: C23H45N3O4Si2. Mole weight: 483.79. | |
5,6-Dihydrouridine Quick inquiry Where to buy Suppliers range | 5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%), which is a derivative of Uridine. Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. Synonyms: Dihydro-1-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione; Dihydrouridine; 1-β-D-Ribofuranosyl-hydrouracil; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(β-L-Ribofuranosyl)dihydro-2,4(1H,3H)-pyrimidinedione. Grades: ≥95%. CAS No. 5627-5-4. Molecular formula: C9H14N2O6. Mole weight: 246.22. | |
Elacytarabine Quick inquiry Where to buy Suppliers range | Elacytarabine (CP-4055) is the lipophilic 5'-elaidic acid ester of the deoxycytidine analog cytosine arabinoside (cytarabine; Ara-C) with potential antineoplastic activity. As a prodrug, CP-4055 is converted intracellularly into cytarabine triphosphate by deoxycytidine kinase and subsequently competes with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis. Compared to cytarabine, CP-4055 shows increased cellular uptake and retention, resulting in increased activation by deoxycytidine kinase to cytarabine triphosphate, decreased deamination and deactivation by deoxycytidine deaminase, and increased inhibition of DNA synthesis. This agent also inhibits RNA synthesis, an effect not seen with cytarabine. Synonyms: CP-4055; CP 4055; CP4055; 5'-O-(Elaidoyl) 1-beta-D-arabinofuranosylcytosine; 5'-Oleoyl cytarabine; (E)-((2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate. CAS No. 188181-42-2. Molecular formula: C27H45N3O6. Mole weight: 507.67. | |
SGI-110 Quick inquiry Where to buy Suppliers range | SGI-110 is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. Uses: Antineoplastic agents. Synonyms: Guadecitabine; SGI 110; SGI110; 2'-deoxy-5-azacytidylyl-(3'->5')-2'-deoxyguanosine; (2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl (((2R,3S,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) hydrogen phosphate. Grades: ≥95%. CAS No. 929901-49-5. Molecular formula: C18H24N9O10P. Mole weight: 557.41. | |
Tetrahydrouridine Quick inquiry Where to buy Suppliers range | Tetrahydrouridine, a derivative of Uridine, is a potent and reversible competitive inhibitor of cytidine deaminase (CDD) (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively). Tetrahydrouridine has the potential to treat tumors with highly expressed CDA as it inhibits cell proliferation through cell cycle regulation despite of cytidine deaminase expression levels deaminase (CDA). Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. Uses: Antimetabolites. Synonyms: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one; NSC 112907; Tetrahydrouridine, NSC 112907; NSC-112907; NSC112907. Grades: 95%. CAS No. 18771-50-1. Molecular formula: C9H16N2O6. Mole weight: 248.23. | |
Tezacitabine Quick inquiry Where to buy Suppliers range | Tezacitabine is a synthetic purine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, further compromising DNA replication. This agent is relatively resistant to metabolic deactivation by cytidine deaminase. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates necessary for DNA synthesis and is overexpressed in many tumor types. Uses: Enzyme inhibitors. Synonyms: MDL 101731; FMdC; KW 2331; MDL 101731; KW2331; MDL101731; Tezacitabine; MDL 101,731; FMdC. CAS No. 130306-02-4. Molecular formula: C10H12FN3O4. Mole weight: 257.221. | |
Zebularine Quick inquiry Where to buy Suppliers range | It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent. Group: Biochemicals. Alternative Names: 1- β-D-Ribofuranosyl-. Grades: Highly Purified. CAS No. 3690-10-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Zebularine Quick inquiry Where to buy Suppliers range | Zebularine is a nucleoside analogue of cytidine. It is a transition state analogue inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. It can inhibit DNA methylation and tumor growth in vitro and in vivo. Synonyms: 1-b-D-Ribofuranosyl-2-(1H)-pyrimidinone; 4-Deoxyuridine; NSC 309132; NSC309132; NSC-309132; Pyrimidin-2-one β-D-Ribofuranoside; 1-beta-D-ribofuranosylpyrimidin-2(1H)-one; 2-Pyrimidone-1-beta-D-riboside; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one. Grades: ≥95%. CAS No. 3690-10-6. Molecular formula: C9H12N2O5. Mole weight: 228.20. |