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| Product | Description | |
|---|---|---|
| cytidine kinase | The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in a pathway for nucleoside degradation. The enzyme can also act on deoxycytidine and uridine, but unlike EC 2.7.1.48, uridine kinase, it is most active with cytidine. Group: Enzymes. Enzyme Commission Number: EC 2.7.1.213. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3049; cytidine kinase; EC 2.7.1.213. Cat No: EXWM-3049. |  |
| 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here). Group: Enzymes. Synonyms: CDP-ME kinase. Enzyme Commission Number: EC 2.7.1.148. CAS No. 263016-77-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2978; 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; EC 2.7.1.148; 263016-77-9; CDP-ME kinase. Cat No: EXWM-2978. | |
| deoxycytidine kinase | Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors. Group: Enzymes. Synonyms: deoxycytidine kinase (phosphorylating); 2'-deoxycytidine kinase; Ara-C kinase; arabinofuranosylcytosine kinase; deoxycytidine-cytidine kinase. Enzyme Commission Number: EC 2.7.1.74. CAS No. 9039-45-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3104; deoxycytidine kinase; EC 2.7.1.74; 9039-45-6; deoxycytidine kinase (phosphorylating); 2'-deoxycytidine kinase; Ara-C kinase; arabinofuranosylcytosine kinase; deoxycytidine-cytidine kinase. Cat No: EXWM-3104. | |
| 2'-AHC-cCMP-Agarose | 2'-AHC-cCMP-Agarose is the putative second messenger cCMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cCMP-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)cytidine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. |  |
| Cytidine 5'-diphosphate trisodium salt | Cytidine 5'-diphosphate trisodium salt (CDP) is produced by the transfer of phosphoryl group from ATP to cytidine monophosphate (CMP) catalyzed by uridine monophosphate kinase (UMPK). Cytidine 5-diphosphate can be used to produce Cytidine triphosphate (CTP) for synthesis of DNA and RNA [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: CDP. CAS No. 34393-59-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W008915. |  |
| Cytidine, N-?benzoyl-?3'-?deoxy-?3'-?[[ (4-?methoxyphenyl) ?diphenylmethyl]?amino]?-?2'-?O-?2-?propen-?1-?yl- | Cytidine, N-benzoyl-3'-deoxy-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-2'-O-2-propen-1-yl is a complex and formidable inhibitor of epidermal growth factor receptor kinase activity. With selectivity and potency, this compound is a key tool in the fight against various tumors, including non-small cell lung cancer, colorectal cancer, head and neck cancer, and pancreatic cancer. The power of this compound extends beyond the realm of tumors and into the world of infectious diseases, with significant efficacy against viruses such as hepatitis B and hepatitis C. CAS No. 2299283-60-4. Molecular formula: C39H38N4O6. Mole weight: 658.74. | |
| (d)CMP kinase | The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP), using ATP as the preferred phosphoryl donor. Unlike EC 2.7.4.14, a eukaryotic enzyme that phosphorylates UMP and CMP with similar efficiency, the prokaryotic enzyme phosphorylates UMP with very low rates, and this function is catalysed in prokaryotes by EC 2.7.4.22, UMP kinase. The enzyme phosphorylates dCMP nearly as well as it does CMP. Group: Enzymes. Synonyms: prokaryotic cytidylate kinase; deoxycytidylate kinase; dCMP kinase; deoxycytidine monophosphokinase. Enzyme Commission Number: EC 2.7.4.25. dCMP kinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3207; (d)CMP kinase; EC 2.7.4.25; prokaryotic cytidylate kinase; deoxycytidylate kinase; dCMP kinase; deoxycytidine monophosphokinase. Cat No: EXWM-3207. | |
| Elacytarabine | Elacytarabine (CP-4055) is the lipophilic 5'-elaidic acid ester of the deoxycytidine analog cytosine arabinoside (cytarabine; Ara-C) with potential antineoplastic activity. As a prodrug, CP-4055 is converted intracellularly into cytarabine triphosphate by deoxycytidine kinase and subsequently competes with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis. Compared to cytarabine, CP-4055 shows increased cellular uptake and retention, resulting in increased activation by deoxycytidine kinase to cytarabine triphosphate, decreased deamination and deactivation by deoxycytidine deaminase, and increased inhibition of DNA synthesis. This agent also inhibits RNA synthesis, an effect not seen with cytarabine. Synonyms: CP-4055; CP 4055; CP4055; 5'-O-(Elaidoyl) 1-beta-D-arabinofuranosylcytosine; 5'-Oleoyl cytarabine; (E)-((2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate. CAS No. 188181-42-2. Molecular formula: C27H45N3O6. Mole weight: 507.67. | |
| Ethynylcytidine | Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. 3'-C-ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation, and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule. Synonyms: ECyd; TAS-106; TAS 106; TAS106; 3'-C-Ethynylcytidine; AIDS241582; AIDS 241582; AIDS-241582; SB-596168; SB596168; SB 596168; 3'-Ethynylcytidine. CAS No. 180300-43-0. Molecular formula: C11H13N3O5. Mole weight: 267.241. | |
| Fazarabine | Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. Synonyms: CCRIS 93; CCRIS-93; CCRIS93; NSC 281272; NSC-281272; NSC281272; Ara-AC; 5-Azacytosine arabinoside; 1-beta-D-Arabinofuranosyl-5-azacytosine. CAS No. 65886-71-7. Molecular formula: C8H12N4O5. Mole weight: 244.20. | |
| N-Benzoylcytidine | N-Benzoylcytidine is a substrate for uracil-cytidine kinase 1 (UCK1) and UCK2. N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 13089-48-0. Pack Sizes: 10 mM * 1 mL; 5 g; 25 g. Product ID: HY-78574. | |
| non-specific serine/threonine protein kinase | This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date. Group: Enzymes. Synonyms: A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; pr. Enzyme Commission Number: EC 2.7.11.1. STK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3128; non-specific serine/threonine protein kinase; EC 2.7.11.1; A-kinase; AP50 kinase; | |
| RX-3117 | RX-3117, also known as TV-1360 and fluorocyclopentenylcytosine, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX-3117 is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). This eventually leads to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway. Synonyms: RX3117; RX 3117; TV-1360; TV1360; TV 1360; fluorocyclopentenylcytosine. Grades: >98%. CAS No. 865838-26-2. Molecular formula: C10H12FN3O4. Mole weight: 257.221. | |
| Tezacitabine | Tezacitabine is a synthetic purine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, further compromising DNA replication. This agent is relatively resistant to metabolic deactivation by cytidine deaminase. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates necessary for DNA synthesis and is overexpressed in many tumor types. Uses: Enzyme inhibitors. Synonyms: MDL 101731; FMdC; KW 2331; MDL 101731; KW2331; MDL101731; Tezacitabine; MDL 101,731; FMdC. CAS No. 130306-02-4. Molecular formula: C10H12FN3O4. Mole weight: 257.221. | |
| UMP/CMP kinase | This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase. Group: Enzymes. Synonyms: cytidylate kinase; deoxycytidylate kinase; CTP:CMP phosphotransferase; dCMP kinase; deoxycytidine monophosphokinase; UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase. Enzyme Commission Number: EC 2.7.4.14. CAS No. 37278-21-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3195; UMP/CMP kinase; EC 2.7.4.14; 37278-21-0; cytidylate kinase; deoxycytidylate kinase; CTP:CMP phosphotransferase; dCMP kinase; deoxycytidine monophosphokinase; UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase. Cat No: EXWM-3195. | |
| uridine kinase | Cytidine can act as acceptor; GTP and ITP can act as donors. Group: Enzymes. Synonyms: pyrimidine ribonucleoside kinase; uridine-cytidine kinase; uridine kinase (phosphorylating); uridine phosphokinase. Enzyme Commission Number: EC 2.7.1.48. CAS No. 9026-39-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3078; uridine kinase; EC 2.7.1.48; 9026-39-5; pyrimidine ribonucleoside kinase; uridine-cytidine kinase; uridine kinase (phosphorylating); uridine phosphokinase. Cat No: EXWM-3078. | |
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