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| Product | Description | |
|---|---|---|
| Cytokine-Induced Neutrophil Chemoattractant-3 from rat | >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. |  |
| Cytokine Inhibitor Library | A unique collection of 613 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and most of them are approved to be marketed; - Targets cover various cytokines including IL, CSF, IFN, TNF, TGF-beta family, growth factors, chemokine family, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3600. Categories: Cytokine Inhibitor Libraries. |  |
| 10Z-Hymenialdisine | Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??BrN?O?, Method for Determining. US Biological Life Sciences. |  Worldwide |
| 1,1,3-Trichloroacetone | 1,1,3-Trichloroacetone is a reagent used to synthesize chlorinated 5-hydroxy-4-methyl-2(5H)-furanones and mucochloric acid. In addition, it can also be used to synthesize (+)-Phorbol. Phorbol derivatives are important for biomedical research and capable of stimulating T-cell activation, proliferation and cytokine production. Group: Biochemicals. Grades: Highly Purified. CAS No. 921-03-9. Pack Sizes: 100mg, 500mg. Molecular Formula: C3H3Cl3O. US Biological Life Sciences. | Worldwide |
| 1,2,3,4-Tetra-O-pivaloyl-b-D-glucuronide methyl ester | Inhibiting the activity of the enzymes crucial to the inflammation process, 1,2,3,4-Tetra-O-pivaloyl-b-D-glucuronide methyl ester serves as a crucial drug in treating inflammatory diseases like rheumatoid arthritis. Its therapeutic effect involves regulation of the immune system by modulating the activity of immune cells, thus curtailing the release of cytokines responsible for inflammation. In addition, its anti-inflammatory action extends beyond suppressing cytokine levels, owing to its ability to halt inflammation cascade reactions with marked efficacy, thereby making it a reliable remedy for patients suffering from inflammatory diseases. Synonyms: Methyl 1,2,3,4-tetra-O-pivaloyl-beta-D-glucopyranosyluronate. CAS No. 86448-91-1. Molecular formula: C27H44O11. Mole weight: 544.63. |  |
| 1-(4-(4-Hydroxyphenyl)butan-2-yl)-1H-indole-5,6-diol | 1-(4-(4-Hydroxyphenyl)butan-2-yl)-1H-indole-5,6-diol can be obtained from DL-Norepinephrine Hydrochloride (N674500) which is Antagonist of dibutyryl cyclic-AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Analytical Standard, Impurity of Drug. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C18H19NO3, Molecular Weight: 297.35. US Biological Life Sciences. | Worldwide |
| 28-Ethyl-d4-hydroxy Rapamycin | 28-Ethyl-d4-hydroxy Rapamycin is the labeled analogue of 28-Ethylhydroxy Rapamycin (E678640), an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C53H79D4NO14, Molecular Weight: 962.25. US Biological Life Sciences. | Worldwide |
| 28-Ethylhydroxy Everolimus-d4 Impurity | 28-Ethylhydroxy Everolimus-d4 Impurity is a deuterium labelled 28-Ethylhydroxy-everolimus Impurity (E945435). It is also an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C55H83D4NO15, Molecular Weight: 1006.3. US Biological Life Sciences. | Worldwide |
| 28-Ethylhydroxy Everolimus Impurity | 28-Ethylhydroxy Everolimus Impurity is an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C55H87NO15, Molecular Weight: 1002.28. US Biological Life Sciences. | Worldwide |
| 2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone-d5 | 2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone-d5 is a labelled analogue of 2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone (C365325) and an intermediate in synthesizing DL-Norepinephrine-d6 Hydrochloride 85% (N674502), which is an antagonist of dibutyryl cyclic AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C8H2D5ClO3. US Biological Life Sciences. | Worldwide |
| 2-(Ethoxycarbonyl)cyclohex-1-ene-1-sulfonic acid | An impurity of Resatorvid. Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor that suppresses pro-inflammatory cytokine release by blocking the interaction between TLR4 and downstream adaptor proteins. Synonyms: Resatorvid Impurity 11; 1-Cyclohexene-1-carboxylic acid, 2-sulfo-, 1-ethyl ester; Ethyl 2-sulfo-1-cyclohexene-1-carboxylate; 2-(Ethoxycarbonyl)-1-cyclohexene-1-sulfonic acid; 2-Sulfo-cyclohex-1-enecarboxylic acid ethyl ester. Grade: ≥95%. CAS No. 243984-25-0. Molecular formula: C9H14O5S. Mole weight: 234.27. | |
| 2'-Fucosyllactose | 2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-FL. CAS No. 41263-94-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N9965. |  |
| 2'-Fucosyllactose | 2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-O-DMT-thymidine 3'. Product Category: Inhibitors. Appearance: Off-white solid. CAS No. 41263-94-9. Molecular formula: C18H32O15. Mole weight: 488.44. Purity: 0.9. IUPACName: (2R,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanal. Canonical SMILES: C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@@H]2[C@H]([C@H]([C@H](O[C@H]2O[C@H]([C@@H](CO)O)[C@@H]([C@H](C=O)O)O)CO)O)O)O)O)O. Density: 1.548 g/ml. Product ID: ACM41263949. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2-Hydroxy Imiquimod | 1-(4-Amino-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol, has been shown to activate a toll-like receptor 7/8 Independent Cytokine, which can be used in the design of immunomodulating agents for use as vaccine adjuvants and anticancer treatments. Group: Biochemicals. Grades: Highly Purified. CAS No. 112668-45-8. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C14H16N4O. US Biological Life Sciences. | Worldwide |
| 2-Methyl-4-oxo-4-phenylbutyric Acid | 2-Methyl-4-oxo-4-phenylbutyric Acid is a chemical reagent used in the synthesis of various pharmaceutically active compounds. Used in the synthesis of Minozac, a suppressor of brain proinflammatory cytokine up-regulation. Group: Biochemicals. Grades: Highly Purified. CAS No. 1771-65-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C11H12O3. US Biological Life Sciences. | Worldwide |
| 2-Methylthioadenosine Tiphosphate Tetrasodium Salt | 2-Methylthioadenosine Tiphosphate Tetrasodium Salt is a potent P2-purinoceptor agonist affecting cell proliferation and apoptosis, and cytokine secretion. Also mediates the relaxation of gut smooth muscle. Group: Biochemicals. Grades: Highly Purified. CAS No. 100020-57-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C11H14N5Na4O13P3S, Molecular Weight: 641.2. US Biological Life Sciences. | Worldwide |
| 2-Methylthioadenosine triphosphate tetrasodium salt | 2-Methylthioadenosine triphosphate tetrasodium salt, an ATP analogue, is a potent P2-purinoceptor agonist affecting cell proliferation and apoptosis, and cytokine secretion. It displays an EC50= 240 nM in rat smooth muscle. Uses: Purinergic agonists. Synonyms: 2-Methylthioadenosine-5'-triphosphate tetrasodium salt; 2MeSATP; 2-MeS-ATP tetrasodium salt; 2 MeS ATP tetrasodium salt; 2-MeS-ATP tetrasodium salt; 2-MeS ATP 4Na salt. CAS No. 100020-57-3. Molecular formula: C11H14N5Na4O13P3S. Mole weight: 641.2. | |
| 2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate | 2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate is an intermediate in the synthesis of 28-Ethylhydroxy Rapamycin (E678640), which is an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C10H20Cl3NO2Si. US Biological Life Sciences. | Worldwide |
| 3',4'-Dimethoxy-α-naphthoflavone | 3',4'-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation. Group: Biochemicals. Alternative Names: DiMNF; 2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one, NSC 123391; 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one. Grades: Highly Purified. CAS No. 14756-24-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-(4-Octadecylbenzoyl)acrylic acid | 3-(4-Octadecylbenzoyl)acrylic acid is a compound in the research of skin diseases like psoriasis, eczema and acne. It possesses anti-inflammatory and antioxidant properties. This product inhibits the production of certain enzymes and cytokines responsible for the inflammation process. Synonyms: 2-Butenoic acid, 4-(4-octadecylphenyl)-4-oxo-; 4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid. Grade: 95%. CAS No. 134531-42-3. Molecular formula: C28H44O3. Mole weight: 428.65. | |
| 3,5-O-Benzylidene-L-lyxono-1,4-lactone | 3,5-O-Benzylidene-L-lyxono-1,4-lactone is an exceedingly powerful pharmaceutically active compound employed extensively in the research of inflammation as well as autoimmune disorders. Demonstrating remarkable capabilities as an anti-inflammatory compound, it effectively hinders the function of pro-inflammatory cytokines and enzymes. Synonyms: 3,5-O-benzylidene-L-lyxonolactone; (4aS,7R,7aS)-7-hydroxy-2-phenyl-4,4a,7,7a-tetrahydrofuro[3,2-d][1,3]dioxin-6-one. Grade: 95%. Molecular formula: C12H12O5. Mole weight: 236.22. | |
| 3'-dC-CPG | 3'-dC-CPG is a DNA product that plays an essential role in the biomedical industry. It is used to treat various viral diseases by stimulating the immune system to identify and eliminate infected cells. This is achieved by binding to Toll-like receptors and activating immune cells to produce antiviral cytokines. 3'-dC-CPG is also used in the development of vaccines and cancer therapies due to its ability to enhance the immune response against cancer cells. Synonyms: 5'-Dimethoxytrityl-N-benzoyl-3'-deoxyCytosine, 2'-succinoyl-long chain alkylamino-CPG 500. Mole weight: 289.18. | |
| 4-[1-Chloro-2-(methylamino)ethyl]phenyl Acetate Hydrochloride | CpdA is a non-steroidal selective glucocorticoid receptor modulator. It can inhibit the dimerization of glucocorticoid receptor, which prevents transcription of gene targets such as NF-κB and subsequent cytokines through transrepression. Synonyms: acetic acid [4-[1-chloro-2-(methylamino)ethyl]phenyl] ester; hydrochloride; [4-[1-chloro-2-(methylamino)ethyl]phenyl] acetate; hydrochloride. Grade: ≥ 98 %. CAS No. 14593-25-0. Molecular formula: C11H15Cl2NO2. Mole weight: 264.15. | |
| 4-Acetyl Rhein | An impurity in the Diacerein bulk drug. Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis. Synonyms: 4-acetoxy-5-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; Diacerein EP Impurity E; Monoacetyl Rhein Isomer B. CAS No. 875535-36-7. Molecular formula: C17H10O7. Mole weight: 326.26. | |
| 4-Di-1-ASP | 4-Di-1-ASP is a styryl dye used to stain glioma cells in living brain tissue for analysis of cell structure, viability, proliferation and endocytosis, cytokinesis and phagocytosis, as well as for observation of mitochondrial structures in living cells. 4-Di-1-ASP fluoresces green when imaged microscopically (?ex /?em = 475/606 nm) [1][2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 959-81-9. Pack Sizes: 200 mg. Product ID: HY-W094758A. | |
| 4-Octyl itaconate | 4-Octyl itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1. It activates Nrf2. It inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. It decreases cytokine production in response to LPS in mice and prolongs survival. Synonyms: Itaconic acid 4-octyl ester; 2-Methylidene-4-octoxy-4-oxobutanoic acid. Grade: ≥98%. CAS No. 3133-16-2. Molecular formula: C13H22O4. Mole weight: 242.3. | |
| 5,15-DPP | Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. 5,15-DPP is a cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM). Synonyms: 5,15-Diphenylporphyrin; STAT3 Inhibitor VIII; 5,15-Diphenyl-21H,23H-porphine. Grade: ≥95%. CAS No. 22112-89-6. Molecular formula: C32H22N4. Mole weight: 462.6. | |
| (+)-[6]-Gingerol | (+)-[6]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. (+)-[6]-Gingerol down regulates proinflammatory cytokine release by macrophages. (+)-[6]-Gingerol has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Group: Biochemicals. Alternative Names: (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (S)-(+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (5S)-[6]-Gingerol; (S)-(+)-[6]Gingerol; (S)-[6]Gingerol; [6]-Gingerol. Grades: Highly Purified. CAS No. 23513-14-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6-OAU | 6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GTPL5846. CAS No. 83797-69-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12764. | |
| 7,3',4'-Tri-O-Methylluteolin | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 29080-58-8. Molecular formula: C18H16O6. Mole weight: 328.32. Purity: 0.99. Product ID: ACM29080588. Alfa Chemistry ISO 9001:2015 Certified. | |
| 9-OAHSA | 9-OAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-OAHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression. 9-OAHSA is also a protective molecule to prevent colon carcinoma cells from apoptotic cell death [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 154086-90-5. Pack Sizes: 1 mg (17.70 mM * 100 μL in Methyl acetate). Product ID: HY-131934. | |
| Aceclofenac | Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. It works by blocking the action of a substance in the body called cyclo-oxygenase. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: Preservex; Aceclofenac; YT-919; YT 919; YT919; Airtal; Beofenac. Grade: >98%. CAS No. 89796-99-6. Molecular formula: C16H13Cl2NO4. Mole weight: 354.18. | |
| Adenophorine | Adenophorine, a promising compound, exhibits efficacy in the treatment of inflammatory conditions through the suppression of pro-inflammatory cytokine secretion. Furthermore, its anti-cancer attributes are manifested through the initiation of apoptosis in malignant cells. Synonyms: (2R,3R,4S,5S,6R)-2-ethyl-6-(hydroxymethyl)piperidine-3,4,5-triol. Molecular formula: C8H17NO4. Mole weight: 191.22. | |
| AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide) | Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 924416-43-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Agaroctaitol | Agaroctaitol is a cutting-edge compound, standing as a prominent solution for studying inflammatory bowel diseases, namely Crohn's disease and ulcerative colitis. This compound serves as an impressive inhibitor of pro-inflammatory cytokines. Synonyms: O-β-D-Galactopyranosyl-(1→4)-O-3,6-anhydro-α-L-galactopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→4)-O-3,6-anhydro-α-L-galactopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→4)-O-3,6-anhydro-α-L-galactopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→3)-1,4-anhydro-D-galactitol; [O-β-D-Galactopyranosyl-(1→4)-O-3,6-anhydro-α-L-galactopyranosyl-(1→3)]3-O-β-D-galactopyranosyl-(1→3)-1,4-anhydro-D-galactitol. Grade: ≥97% by GPC. CAS No. 137042-78-5. Molecular formula: C48H76O37. Mole weight: 1245.09. | |
| AhR Agonist V, VAF347 | A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation. Group: Biochemicals. Alternative Names: ((4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine). Grades: Highly Purified. CAS No. 574759-62-9. Pack Sizes: 10mg. Molecular Formula: C??H??ClF?N?, Molecular Weight: 349.7. US Biological Life Sciences. | Worldwide |
| AICAR | AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy , YAP and mitophagy inhibitor [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Acadesine; AICA Riboside. CAS No. 2627-69-2. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13417. | |
| AICAR phosphate | AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy , YAP and mitophagy inhibitor [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Acadesine phosphate; AICA Riboside phosphate. CAS No. 681006-28-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13417A. | |
| Almurtide | Almurtide, also known as romurtide, is a synthetic muramyl dipeptide (MDP) H8analogue with potential immunostimulating and antineoplastic activity. As a derivative of the mycobacterial cell wall component MDP, almurtide activates both monocytes and macrophages. This results in the secretion of cytokines and induces the recruitment and activation of other immune cells, which may result in indirect tumoricidal or cytostatic effects. Synonyms: CGP 11637; CGP11637; CGP-11637; norMDP; N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine. CAS No. 61136-12-7. Molecular formula: C18H30N4O11. Mole weight: 478.46. | |
| AMG-47a | AMG-47a is an orally active, ATP-competitive Lck inhibitor (IC50=0.2 nM). AMG-47a inhibits VEGF2, p38?, p38?, Jak3, MLR, and IL-2 with IC50 of 1 nM, 3 nM, 72 nM, 30 nM, and 21 nM, respectively. AMG-47a reduces T cell activation and the production of cytokines such as TGF-?, exerting anti-inflammatory and anti-fibrotic activities. AMG-47a can be used in the research of autoimmune diseases, pulmonary fibrosis, and KRAS mutation-associated cancers[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 882663-88-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-18303. | |
| Amivantamab | Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JNJ-61186372. CAS No. 2171511-58-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9977. | |
| Anamorelin Fumarate | Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite. Synonyms: RC-1291 Fumarate; ONO-7643 Fumarate; RC1291 Fumarate; ONO7643 Fumarate; RC 1291 Fumarate; ONO 7643 Fumarate. Grade: >98%. CAS No. 339539-92-3. Molecular formula: C35H46N6O7. Mole weight: 662.78. | |
| Antibiotic LL Z1640-2 (Antibiotic C292, Antibiotic L 783278) | Antibiotic LL Z1640-2 a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in an animal models. Group: Biochemicals. Alternative Names: Antibiotic C292, Antibiotic L 783278. Grades: Highly Purified. CAS No. 66018-38-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Anti-inflammatory agent 7 | Anti-inflammatory agent 7 can inhibit proinflammatory cytokines by blocking the NF-κB/MAPK signaling pathway in LPS-treated RAW 264.7 cells as well as mice. Molecular formula: C36H40N4O9. Mole weight: 672.72. | |
| AP1189 acetate | AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ~3-fold. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AP-1189; AP 1189; AP1189; AP1189 acetate. Product Category: Agonists. Appearance: Solid powder. CAS No. 959850-74-9. Molecular formula: C16H18N6O4. Mole weight: 358.36. Purity: >98%. IUPACName: (E)-N-[trans-3-{1-(2-Nitrophenyl)-1H-pyrrol-2-yl} allylidenamino]guanidinium acetate. Canonical SMILES: NC(N/N=C/C=C/C1=CC=CN1C2=CC=CC=C2[N+]([O-])=O)=N.CC(O)=O. Product ID: ACM959850749. Alfa Chemistry ISO 9001:2015 Certified. Categories: Resomelagon acetate. | |
| Apilimod | Apilimod is a potent and orally bioavailable inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases by inhibition of IL-12 and IL-23 production. Synonyms: STA-5326; STA 5326; STA5326; N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine. Grade: 99%. CAS No. 541550-19-0. Molecular formula: C23H26N6O2. Mole weight: 418.49. | |
| Apilimod mesylate | The mesylate salt form of Apilimod. Apilimod is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases by inhibition of IL-12 and IL-23 production. Synonyms: methanesulfonic acid N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine. Grade: 98%. CAS No. 870087-36-8. Molecular formula: C23H26N6O2.2CH4O3S. Mole weight: 610.7. | |
| Arctiin | Arctiin is an orally active inhibitor of NF-κB. Arctiin suppresses cyclin D1 protein expression in human tumor cells. Arctiin also reduces malondialdehyde and pro-in?ammatory cytokines levels. Arctiin can used in study glomerulonephritis [4] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: Arctii; NSC 315527; Arctigenin-4-glucoside. CAS No. 20362-31-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N0034. | |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grade: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42. | |
| Arg-Gly-Asp-Ser acetate | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Molecular formula: C17H31N7O10. Mole weight: 493.47. | |
| AS1940477 | AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg/kg (ED(50)=0.053 mg/kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this study demonstrated that AS1940477 is a novel and potent p38 MAPK inhibitor and may be useful as a promising anti-inflammatory agent for treating inflammatory disorders. Synonyms: AS1940477; AS-1940477; AS 1940477. CAS No. 928344-12-1. Molecular formula: C24H22FN5O2. Mole weight: 431.47. | |
| Ascomycin | Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells.Ascomycin (also known as Immunomycin, FR 900520, and FK-520) is an analog of tacrolimus (FK-506) with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant, and to treat autoimmune diseases and skin diseases.Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9: 69-77 (2000). Moll...the compounds." J. Infect. Dis. 191: 1342-1349 (2005).FK-520 might be a substrate for P-glycoprotein; expression of P-glycoprotein in yeast cells resulted in resistance to growth inhibition by FK-520. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14: 277-286 (1994). Group: Biochemicals. Alternative Names: Immunomycin; FK-520; FR-520; NSC-106410; FR 900520; L 683590; Changchuanmycin. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C43H69NO12, Molecular Weight: 792.01. US Biological Life Sciences. | Worldwide |
| Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A) | Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Group: Biochemicals. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Atractylenolide I | Atractylenolide I is a sesquiterpenoid found in the rhizome of Atractylodes macrocephala. Atractylenolide I ameliorates sepsis syndrome by reduction of pro-inflammatory cytokines and LPS, and provides an improvement in liver and kidney functions. Uses: Anti-inflammatory. Synonyms: ATRACTYLENOLIDE-1; (4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one; 3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one; Eudesma-4(15),7(11),8-trien-12-olide; 8,9-Dehydroasterolide. Grade: >98%. CAS No. 73069-13-3. Molecular formula: C15H18O2. Mole weight: 230.3. | |
| Aurora Kinase Inhibitor II | The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A with IC50 of 0.39 μM. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. Synonyms: 4-(4?-Benzamidoanilino)-6,7-dimethoxyquinazoline. Grade: ≥98%. CAS No. 331770-21-9. Molecular formula: C23H20N4O3. Mole weight: 400.4. | |
| Bardoxolone | Bardoxolone (RTA 401; CDDO) is a novel nuclear regulatory factor ( NRf-2 ) activator. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis. Bardoxolone methyl enhances the antioxidant system, modulates inflammatory cytokines and inhibits apoptosis in rat kidney, demonstrating inhibition on APAP-induced acute kidney injury (AKI) and analgesic effect. Additionally, Bardoxolone methyl decreases Paclitaxel (PAC) (HY-B0015)-induced mitochondrial damage in neuronal cells. Bardoxolone methyl is promising for the research of chemotherapy-induced neuropathic pain and chronic kidney disease [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDDO; RTA 401. CAS No. 218600-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14909. | |
| Bavachinin | Bavachinin is a natural compound isolated from the Chinese herb Fructus Psoraleae. Bavachinin has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. It significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Uses: Antiinflammatory; antipyretic; analgesic. Synonyms: 7-O-Methylbavachin; Bavachinin A. Grade: >98%. CAS No. 19879-30-2. Molecular formula: C21H22O4. Mole weight: 338.4. | |
| BAY 11-7082 | BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. Synonyms: BAY 11-7821; BAY 11-7082; BAY11-7082; BAY-11-7082; BAY 117082; BAY117082; BAY-117082. Grade: >98%. CAS No. 19542-67-7. Molecular formula: C10H9NO2S. Mole weight: 207.25. | |
| BAY 11-7082 | IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. Inflammasome inhibitor Inhibits platelet aggregation. Group: Biochemicals. Alternative Names: (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile. Grades: Highly Purified. CAS No. 19542-67-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C10H9NO2S. US Biological Life Sciences. | Worldwide |
| BAY 61-3606 hydrochloride | BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki=7.5 nM; IC50=10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. It shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma. Synonyms: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide monohydrochloride; BAY 61-3606 HCl. Grade: ≥98%. CAS No. 1615197-10-8. Molecular formula: C20H18N6O3·HCl. Mole weight: 426.9. | |
| BBT | BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753))-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/ CaMK2 pathway [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 445000-45-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 100 mg. Product ID: HY-Q40876. | |
| BC-1215 | BC-1215 is a F-box protein 3 (Fbxo3) inhibitor. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 can be used for the research of inflammation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1507370-20-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117937. | |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metast | |
| Benzyl 4-O-b-D-glucuronyl-b-D-xylopyranoside | Benzyl 4-O-b-D-glucuronyl-b-D-xylopyranoside is a remarkable and potent compound with pronounced anti-inflammatory attributes. Its mode of action entails proficiently subduing pro-inflammatory cytokines and effectively impeding the NF-κB signaling pathway. Molecular formula: C18H24O11. Mole weight: 416.38. | |
| Besifloxacin | Besifloxacin is a novel 8-chloro-fluoroquinolone agent with potent, bactericidal activity against prevalent and drug-resistant pathogens. Besifloxacin has been found to inhibit production of pro-inflammatory cytokines in vitro. Uses: Anti-bacterial agents. Synonyms: (R)-7-(3-aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. Grade: 99%. CAS No. 141388-76-3. Molecular formula: C19H21ClFN3O3. Mole weight: 393.84. | |
| Betulin | Betulin can be found in the barks of Betula alba L. Its nanoparticles powder shows an excellent hypoglycemic effect compared with raw Betulin. Betulin alleviated LPS-induced acute lung injury. Besides, Betulin inhibited pro-inflammatory cytokines expression and NF-κB signaling activation through STAT3 signaling. Betulin can also be used in cosmetics material. Uses: Antineoplastic/anti-hiv. Synonyms: Trochol; Betuline; Betulinic Alcohol; Betulinol; Betulol; (1R,3aS,5aR,5bR,9S,11aR,11bR,13aR,13bR)-3a-(Hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol. Grade: >98%. CAS No. 473-98-3. Molecular formula: C30H50O2. Mole weight: 442.72. | |
| BI-2536 | BI-2563 is a small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division. Synonyms: BI2536; BI 2536; (R)-4-((8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide. Grade: 98%. CAS No. 755038-02-9. Molecular formula: C28H39N7O3. Mole weight: 521.65. | |
| Binucleine 2 | Binucleine 2 is an inhibitor of cytokinesis function of the ARK-2 pathway. It is also an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. Synonyms: Binucleine 2; 220088-42-6; N'-[2-(3-chloro-4-fluorophenyl)-4-cyanopyrazol-3-yl]-N,N-dimethylmethanimidamide; N'-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide; HMS546I06; Probes1_000319; Probes2_000073; CHEMBL1598812; DTXSID90430554; Binucleine 2, >=97% (HPLC); CCG-41865; MFCD00177827; AKOS040755467; NCGC00165742-01; J-014418; SR-01000631912-1; N'-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethylformimidamide. Grade: ≥98%. CAS No. 220088-42-6. Molecular formula: C13H11ClFN5. Mole weight: 291.7. | |
| Bisindolylmaleimide I hydrochloride | Bisindolylmaleimide I hydrochloride (BMI) is a water soluble form of Bisindolylmaleimide I. It is a staurosporine inspired molecule, which has been shown to display equally potent inhibition. BIM I is a highly selective, cell-permeable, and reversible PKC inhibitor with Ki of 14 nM that is structurally similar to the poorly selective PKC inhibitor staurosporine. This compound has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It can inhibit PKC (protein kinase C) within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases. Synonyms: BIM I; GF109203X; Gö 6850. Grade: ≥98%. CAS No. 176504-36-2. Molecular formula: C25H24N4O2·HCl. Mole weight: 449. | |
| (±)-Blebbistatin | (±)-Blebbistatin is a selective inhibitor of myosin II ATPase. It reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Synonyms: Blebbistatin; (±)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one. Grade: ≥98% by HPLC. CAS No. 674289-55-5. Molecular formula: C18H16N2O2. Mole weight: 292.34. | |
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