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| Product | Description | |
|---|---|---|
| CzC | CzC. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(4-tert-Butylphenyl)-3,6-ditrityl-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 956373-04-9. Molecular formula: C60H49N. Mole weight: 784.04 g/mol. Product ID: ACM956373049. Alfa Chemistry ISO 9001:2015 Certified. Categories: xanthosine 5'-(trihydrogen diphosphate), Czchów. |  |
| CZC24832 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| CZC24832 | CZC24832 is the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation. Extensive target- and cell-based profiling of CZC24832 revealed regulation of interleukin-17-producing T helper cell (T(H)17) differentiation by PI3Kγ, thus reinforcing selective inhibition of PI3Kγ as a potential treatment for inflammatory and autoimmune diseases. Synonyms: CZC24832; CZC-24832; CZC 24832. Grade: 0.98. CAS No. 1159824-67-5. Molecular formula: C15H17FN6O2S. Mole weight: 364.399. |  |
| CZC 24832 (5-(2-Amino-8-fluoro[1,2,4]triazolo[ 1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridi nesulfonamide) | Selective inhibitor of PI 3-Kinase gamma (IC50 = 1.0um in a PI 3-Kgamma-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 1159824-67-5. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CZC-25146 | CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons. Synonyms: CZC25146; CZC 25146. Grade: >98%. CAS No. 1191911-26-8. Molecular formula: C22H25FN6O4S. Mole weight: 488.54. | |
| CZC-25146 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CZC-25146 hydrochloride | CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons's disease, and is ATP-competitive. Synonyms: CZC25146 hydrochloride; CZC 25146 hydrochloride. Grade: 0.98. CAS No. 1330003-04-7. Molecular formula: C22H26ClFN6O4S. Mole weight: 524.996. | |
| CZC-54252 | Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Synonyms: CZC-54252; CZC 54252; CZC54252. Grade: >98%. CAS No. 1191911-27-9. Molecular formula: C22H25ClN6O4S. Mole weight: 504.99. | |
| CZC-54252 HCl | CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively. CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CZC-54252 HCl; CZC-54252 hydrochloride; CZC-54252; CZC 54252; CZC54252. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45. Purity: >98%. IUPACName: N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride. Canonical SMILES: CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl. Product ID: ACM1784253059. Alfa Chemistry ISO 9001:2015 Certified. | |
| CZC 54252 hydrochloride | CZC 54252 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1191911-27-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CZC-54252 hydrochloride | CZC-54252 hydrochloride is a potent and selective inhibitor of LRRK2 with IC50s of 1.28 and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM. It has a neuroprotective activity. Synonyms: Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1); N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride. Grade: ≥95%. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45. | |
| CZC-8004 | CZC-8004 is an aminopyrimidine which is a pan-kinase inhibitor that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. Synonyms: Dianilinopyrimidine-01; CZC-00008004. Grade: ≥98%. CAS No. 916603-07-1. Molecular formula: C17H16FN5. Mole weight: 309.3. | |
| LRRK2 Inhibitor II, CZC-25146 (N- (2- (5-Fluoro-2- (2-methoxy-4-morpholinophenylamino) pyrimidin-4-ylamino) phenyl) methanesulfonamide, HCl, N- (2- (2- (2-Methoxy-4-morpholinophenylamino) -5-fluoropyrimidin-4-ylamino) phenyl) methanesulfonamide, HCl) | An orally bioavailable fluoro-diaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of LRRK2 activity (IC50=4.76 and 6.87nM for hr-wt-LRRK2 and G2019S-LRRK2 mutant, respectively) with selectivity over PLK4, GAK, TNK1, CAMKK2, and PIP4K2C (IC50 <300nM) in a 185-kinase panel. Does neither exert cytotoxicity nor block neuronal development of human or rat cortical neurons at 1uM. Shown to prevent GS-LRRK2-induced neuronal injury (EC50 ~4nM) and G2019S- or R1441C-LRRK2-mediated neuronal death in both rat and human cortical neurons (EC50 ~100nM). Even though exhibits favorable pharmacokinetic profile and metabolic stability, and yet suffers from limited blood brain barrier penetration (~4%). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| LRRK2 Inhibitor III, HG-10-102-01 (Leucine-Rich Repeat Kinase 2 Inhibitor III, Mixed-Lineage Kinase 1 Inhibitor I, MLK1 Inhibitor I, MNK Inhibitor III, (4- (5-Chloro-4- (methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl) (morpholino)methanone) | A cell-permeable 2,4-diaminopyrimidinyl compound that acts as a potent, ATP-competitive LRRK2-selective inhibitor (IC5050 = 20.3, 3.2, 153.7 and 95.9nM, respectively,against human wt LRRK2 and G2019S, A2016T, G2019S/A2016T LRRK2 mutant; [ATP] = 100uM), displaying much reduced potency against MNK2 and MLK1 (IC50 = 0.6 and 2.1uM, respectively; [ATP] = 100uM) and little activity toward a panel of 136 other kinases. Although both HG-10-102-01 and LRRK2-In-1 inhibit cellular wt and G20195 LRRK2 phosphorylation (Optimal conc. 1 to 3uM), only HG-10-102-01 is effective against cellular A2016T and G2019S/A2016T LRRK2 phosphorylations (IC50 <3uM). And only HG-10-102-01, but not LRRK2-In-1 or CZC-25146, can cross blood-brain-barrier for LRRK2 phosphorylation inhibition in mice (30mg/kg to 50mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
| N- (2- (2- (2-Methoxy-4-morpholinophenylamino) -5-fluoropyrimidin-4-ylamino) phenyl) methanesulfonamide | N- (2- (2- (2-Methoxy-4-morpholinophenylamino) -5-fluoropyrimidin-4-ylamino) phenyl) methanesulfonamide. Group: Biochemicals. Alternative Names: CZC-25146. Grades: Highly Purified. CAS No. 1191911-26-8. Pack Sizes: 10mg. Molecular Formula: C22H25FN6O4S, Molecular Weight: 488.54. US Biological Life Sciences. | Worldwide |
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