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| Product | Description | |
|---|---|---|
| CZC-54252 | Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Synonyms: CZC-54252; CZC 54252; CZC54252. Grade: >98%. CAS No. 1191911-27-9. Molecular formula: C22H25ClN6O4S. Mole weight: 504.99. |  |
| CZC-54252 HCl | CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively. CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CZC-54252 HCl; CZC-54252 hydrochloride; CZC-54252; CZC 54252; CZC54252. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45. Purity: >98%. IUPACName: N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride. Canonical SMILES: CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl. Product ID: ACM1784253059. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CZC-54252 hydrochloride | CZC-54252 hydrochloride is a potent and selective inhibitor of LRRK2 with IC50s of 1.28 and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM. It has a neuroprotective activity. Synonyms: Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1); N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride. Grade: ≥95%. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45. | |
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