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| Product | Description | |
|---|---|---|
| D-Ala-D-Ala | D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 923-16-0. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-W015450. |  |
| D-Ala-D-Ala dipeptidase | A Zn2+-dependent enzyme. The enzyme protects Enterococcus faecium from the antibiotic vancomycin, which can bind to the -D-Ala-D-Ala sequence at the C-terminus of the peptidoglycan pentapeptide (see diagram). This enzyme reduces the availability of the free dipeptide D-Ala-D-Ala, which is the precursor for this pentapeptide sequence, allowing D-Ala-(R)-lactate (for which vancomycin has much less affinity)to be added to the cell wall instead. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. Belongs in peptidase family M15. Group: Enzymes. Synonyms: D-alanyl-D-alanine dipeptidase; vanX D-Ala-D-Ala dipeptidase; VanX. Enzyme Commission Number: EC 3.4.13.22. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4036; D-Ala-D-Ala dipeptidase; EC 3.4.13.22; D-alanyl-D-alanine dipeptidase; vanX D-Ala-D-Ala dipeptidase; VanX. Cat No: EXWM-4036. |  |
| D-Ala-D-Ala-OH | D-Ala-D-Ala-OH. Group: Biochemicals. Alternative Names: D-Alanyl-D-alanine. Grades: Highly Purified. CAS No. 923-16-0. Pack Sizes: 250mg, 500mg, 1g. US Biological Life Sciences. |  Worldwide |
| D-Ala-D-Ala-OH | Synonyms: D-Alanyl-D-alanine. Grades: ≥ 99% (HPLC). CAS No. 923-16-0. Molecular formula: C6H12N2O3. Mole weight: 160.17. |  |
| D-Ala-D-Ala-OH ≥95% (HPLC) | D-Ala-D-Ala-OH ≥95% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 923-16-0. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| Ala-D-γ-Glu-Lys-D-Ala-D-Ala | Ala-D-γ-Glu-Lys-D-Ala-D-Ala is the pentapeptide tail of the peptidoglycan precursor UDPMurNAc-l-Ala-γ-d-Glu-l-Lys(Gly)(5)-d-Ala-d-Ala [1]. Uses: Scientific research. Group: Peptides. CAS No. 2614-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P5919. | |
| Cyclo(-D-Ala-D-Ala) | Cyclo(-D-Ala-D-Ala). Group: Biochemicals. Grades: Highly Purified. CAS No. 23927-13-1. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Cyclo(-D-Ala-D-Ala) | Synonyms: (3R,6R)-3,6-Dimethylpiperazine-2,5-Dione. Grades: ≥ 99% (Assay). CAS No. 23927-13-1. Molecular formula: C6H10N2O2. Mole weight: 142.16. | |
| Cyclo(-D-Ala-D-Ala) 99+% (HPLC) | Cyclo(-D-Ala-D-Ala) 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| serine-type D-Ala-D-Ala carboxypeptidase | A membrane-bound, bacterial enzyme inhibited by penicillin and other β-lactam antibiotics, which acylate the active site serine. Examples are known from peptidase families S11, S12 and S13. Distinct from EC 3.4.17.14, zinc D-Ala-D-Ala carboxypeptidase. Group: Enzymes. Synonyms: DD-peptidase; D-alanyl-D-alanine-carboxypeptidase; D-alanyl-D-alanine-cleaving-peptidase; D-alanyl-D-alanine-cleaving peptidase; DD-transpeptidase; D-alanine carboxypeptidase; DD-carboxypeptidase; D-alanyl carboxypeptidase. Enzyme Commission Number: EC 3.4.16.4. CAS No. 9077-67-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4058; serine-type D-Ala-D-Ala carboxypeptidase; EC 3.4.16.4; 9077-67-2; DD-peptidase; D-alanyl-D-alanine-carboxypeptidase; D-alanyl-D-alanine-cleaving-peptidase; D-alanyl-D-alanine-cleaving peptidase; DD-transpeptidase; D-alanine carboxypeptidase; DD-carboxypeptidase; D-alanyl carboxypeptidase. Cat No: EXWM-4058. | |
| zinc D-Ala-D-Ala carboxypeptidase | A zinc enzyme. Catalyses carboxypeptidation but not transpeptidation reactions involved in bacterial cell wall metabolism. Weakly inhibited by β-lactams. In peptidase family M15. Distinct from EC 3.4.16.4, serine-type D-Ala-D-Ala carboxypeptidase. Group: Enzymes. Synonyms: Zn2+ G peptidase, D-alanyl-D-alanine hydrolase; D-alanyl-D-alanine-cleaving carboxypeptidase; DD-carboxypeptidase; G enzyme; DD-carboxypeptidase-transpeptidase. Enzyme Commission Number: EC 3.4.17.14. CAS No. 213189-85-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4066; zinc D-Ala-D-Ala carboxypeptidase; EC 3.4.17.14; 213189-85-6; Zn2+ G peptidase, D-alanyl-D-alanine hydrolase; D-alanyl-D-alanine-cleaving carboxypeptidase; DD-carboxypeptidase; G enzyme; DD-carboxypeptidase-transpeptidase. Cat No: EXWM-4066. | |
| D-stereospecific aminopeptidase | Known from the bacterium Ochrobactrum anthropi. In peptidase family S12 (D-Ala-D-Ala carboxypeptidase family). Group: Enzymes. Synonyms: D-aminopeptidase. Enzyme Commission Number: EC 3.4.11.19. CAS No. 57534-78-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4015; D-stereospecific aminopeptidase; EC 3.4.11.19; 57534-78-8; D-aminopeptidase. Cat No: EXWM-4015. | |
| N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase | This enzyme catalyses the successive transfer of two Gly moieties from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc, attaching them to a Gly residue previously attached by EC 2.3.2.16 (lipid II:glycine glycyltransferase) to the N6 of the L-Lys at position 3 of the pentapeptide. This is the second step in the synthesis of the pentaglycine interpeptide bridge that is used by Staphylococcus aureus for the crosslinking of different glycan strands to each other. The next step is catalysed by EC 2.3.2.18 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-...D-alanine-ditrans,octacis-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase. Enzyme Commission Number: EC 2.3.2.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2290; N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase; EC 2.3.2.17; femA (gene name); N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-ditrans,octacis-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase. Cat No: EXWM-2290. | |
| N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase | This Staphylococcus aureus enzyme catalyses the successive transfer of two Gly moieties from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphosphoundecaprenyl-GlcNAc, attaching them to the three Gly molecules that were previously attached to the N6 of the L-Lys at position 3 of the pentapeptide by EC 2.3.2.16 (lipid II:glycine glycyltransferase) and EC 2.3.2.17 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase). This is the last step in the synthesis of the pentaglycine interpeptide bridge tha...ditrans,octacis-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase. Enzyme Commission Number: EC 2.3.2.18. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2291; N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase; EC 2.3.2.18; femB (gene name); N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-ditrans,octacis-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase. Cat No: EXWM-2291. | |
| UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase | Involved with EC 6.3.2.4 (D-alanine-D-alanine ligase), EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate-L-alanine ligase) and EC 6.3.2.9 (UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase) in the synthesis of a cell-wall peptide (click here) for diagram. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-centre), linking the D-Ala-D-Ala to the carboxy group of the L-centre. This activity was previously attributed to EC 6.3.2.15, which has since been deleted. Group: Enzymes. Synonyms: MurF s. Enzyme Commission Number: EC 6.3.2.10. CAS No. 55354-36-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5731; UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase; EC 6.3.2.10; 55354-36-4; MurF synthetase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase; UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase; uridine diphosphoacetylmuramoylpentapeptide synthetase; UDPacetylmuramoylpentapeptide synthetase; UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase. Cat No: EXWM-5731. | |
| Vancomycin Hydrochloride | Vancomycin is an aminoglycoside antibiotic, used in the treatment of infections caused by Gram-positive bacteria. vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria). The main target of this antibiotic is the D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors, used by bacteria for constructing their cell walls. This prevents the reaction used to link peptidoglycan precursors together from taking place. Vancomycin binds with the substrate, not the enzyme, in contrast to the way penicillin inhibits peptidoglycan synthesis.The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Under normal circumstances, this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents cell wall synthesis in two ways. It prevents the synthesis of the long polymers of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) that form the backbone strands of the bacterial cell wall, and it prevents the backbone polymers that do manage to form from cross-linking with each other. Group: Biochemicals. Alternative Names: Lyphocin; Meek; Vancocin Hydrochloride; Vancocine Hydrochloride; Vancocyn; Vancor. Grades: Reagent Grade. CAS No. 1404-93-9. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C66H75Cl2N9O24×HCl, Molecular Weight: 1485.7. US Biological Life Sciences. | Worldwide |
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