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| Product | Description | |
|---|---|---|
| D-Amino Acid Oxidase Inhibitor | D-Amino acid oxidase inhibitor is a selective D-amino acid oxidase (DAAO) inhibitor (IC50 = 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively). D-Amino acid oxidase inhibitor (10-200 mg/kg, i.p.) inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner. Synonyms: DAAO inhibitor; 4H-thieno[3,2-b]pyrrole-5-carboxylic acid. Grades: ≥98%. CAS No. 39793-31-2. Molecular formula: C7H5NO2S. Mole weight: 167.2. |  |
| D-Amino Acid Oxidase Inhibitor III, AS057278 (5-methyl-1H-pyrazole-3-carboxylic Acid, DAAO Inhibitor III) | A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910nM against human DAO; [D-ser] = 10mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50mM) exposure (ED50 ≤3.95uM), while exhibiting little affinity toward nMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80mg/kg or 56X 20mg/kg/12h b.i.d. oral dosages) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 402-61-9. Pack Sizes: 50mg. US Biological Life Sciences. |  Worldwide |
| 1-Hydroxy Pioglitazone Hydrochloride | Hydroxy Pioglitazone Hydrochloride is used in the treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 146062-46-6. Pack Sizes: 500ug, 5mg. Molecular Formula: C19H21ClN2O4S, Molecular Weight: 408.9. US Biological Life Sciences. | Worldwide |
| 4-Bromo-2-fluorobenzoic Acid | 4-Bromo-2-fluorobenzoic Acid is a halogenated derivative of benzoic acid. 4-Bromo-2-fluorobenzoic Acid is used in the synthesis of pharmaceutically significant products such as d-Amino acid oxidase inhibitors. Group: Biochemicals. Alternative Names: 2-Fluoro-4-bromobenzoic Acid; NSC 190364; 4-Bromo-2-fluorobenzoic Acid. Grades: Highly Purified. CAS No. 112704-79-7. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| D-Amino Acid Oxidase (Crude Enzyme) | D-Amino Acid Oxidase (DAAO; also DAO, OXDA, DAMOX) is a peroxisomal enzyme containing FAD as cofactor that is expressed in a wide range of species from yeasts to human. It is not present in plants or in bacteria which instead use D-amino acid dehydrogenase. Its function is to oxidize D-amino acids to the corresponding imino acids, producing ammonia and hydrogen peroxide. DAAO is a candidate susceptibility gene and together with G72 may play a role in the glutamatergic mechanisms of schizophrenia. Risperidone andsodium benzoate are inhibitors of DAAO. DAAO is used as a biocatalyst in several biotechnological applications, such as the oxidation of cephalosporin C, the deracem...n may use the morpheein model of allosteric regulation. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Biotechnology; industry; drug development; medicine; pharmacology; analysis; diagnostics; synthesis. Group: Enzymes. Synonyms: ophio-amino-acid oxidase; L-amino acid:O 2 oxidoreductase; new yellow enzyme. Enzyme Commission Number: EC 1.4.3.3. CAS No. 9000-88-8. DAAO. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. ophio-amino-acid oxidase; L-amino acid:O 2 oxidoreductase; new yellow enzyme. Pack: 100ml. Cat No: NATE-1807. |  |
| Luvadaxistat | Luvadaxistat (TAK-831) is an orally active, highly selective, potent D-amino acid oxidase (DAAO) inhibitor. Luvadaxistat inhibits oxidative deamination of D-serine via the human recombinant DAAO enzyme with an IC 50 of 14 nM. Luvadaxistat significantly increases D-serine levels in the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat has the potential for schizophrenia research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-831. CAS No. 1425511-32-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109183. |  |
| O- (2, 4-Dinitrophenyl) hydroxylamine | O- (2, 4-Dinitrophenyl) hydroxylamine is a rapid active-site-directed inhibitor of D-amino acid oxidase; modification results in specific incorporation of an amine group into an accessible nucleophilic residue with concomitant release of 2,4-dinitrophenol. Group: Biochemicals. Alternative Names: 1-Aminooxy-2,4-dinitrobenzene; 2,4-Dinitrophenoxyamine; 2,4-Nitrophenoxyamine; DNPA; NSC 148499. Grades: Highly Purified. CAS No. 17508-17-7. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
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