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| Product | Description | |
|---|---|---|
| Dacomitinib | Dacomitinib, aslo known as PF-299 and PF-00299804; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types. Synonyms: dacomitinib; PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804; PF-299; PF 299; PF299. CAS No. 1110813-31-4. Molecular formula: C24H25ClFN5O2. Mole weight: 469.945. |  |
| Dacomitinib | Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC 50 s of 6 nM, 45.7 nM and 73.7 nM for EGFR , ERBB2 , and ERBB4 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-00299804; PF-299804. CAS No. 1110813-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13272. |  |
| Dacomitinib hydrate | Dacomitinib (PF-00299804) hydrate is an orally active, irreversible pan- ErbB inhibitor. Dacomitinib hydrate can be used in the research of cancers such as metastatic non-small cell lung cancer (NSCLC) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-00299804 hydrate; PF-299804 hydrate. CAS No. 1042385-75-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-118263. | |
| Dacomitinib Hydrate | Dacomitinib is a second-generation small molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) tyrosine kinase family (ErbB family) with potential anti-tumor activity. Uses: Tyrosine kinase inhibitors. Synonyms: PF-00299804; PF00299804; PF 00299804; PF299804. CAS No. 1042385-75-0. Molecular formula: C24H25ClFN5O2.H2O. Mole weight: 487.96. | |
| Dacomitinib Impurity 11 | Dacomitinib Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 13991-36-1. Molecular formula: C4H5BrO2. Mole weight: 164.99. Catalog: APB13991361. |  |
| Dacomitinib Impurity 2F3L | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H25ClFN5O2. Mole weight: 469.95. | |
| Dacomitinib Impurity 3F4L | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H25ClFN5O2. Mole weight: 469.95. | |
| Dacomitinib Impurity 3F4LAJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C15H12ClFN4O. Mole weight: 318.73. | |
| Dacomitinib Impurity 3F4LXJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C15H10ClFN4O3. Mole weight: 348.72. | |
| Dacomitinib Impurity BDS | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C19H16ClFN4O2. Mole weight: 386.81. | |
| Dacomitinib Impurity C | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. CAS No. 869199-69-9. Molecular formula: C25H27ClFN5O2. Mole weight: 483.97. | |
| Dacomitinib Impurity D | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. CAS No. 869199-67-7. Molecular formula: C26H29ClFN5O2. Mole weight: 497.99. | |
| Dacomitinib Impurity DF | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H26FN5O2. Mole weight: 435.50. | |
| Dacomitinib Impurity DFAJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: N4-(4-Fluorophenyl)-7-methoxyquinazoline-4,6-diamine (Dacomitinib Impurity); N4-(4-FLUOROPHENYL)-7-METHOXYQUINAZOLINE-4,6-DIAMINE; Dacomitinib Impurity DFAJ; CS-0255390; F83326. Grades: ≥95%. CAS No. 1562180-31-7. Molecular formula: C15H13FN4O. Mole weight: 284.29. | |
| Dacomitinib Impurity DFXJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. CAS No. 2185841-22-7. Molecular formula: C15H11FN4O3. Mole weight: 314.27. | |
| Dacomitinib Impurity E | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H27ClFN5O3. Mole weight: 487.96. | |
| Dacomitinib Impurity SF | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H25F2N5O2. Mole weight: 453.49. | |
| Dacomitinib Impurity SFAJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: Dacomitinib Impurity SFAJ; CS-0255393; F83329; N4-(3,4-Difluorophenyl)-7-methoxyquinazoline-4,6-diamine; N4-(3,4-DIFLUOROPHENYL)-7-METHOXY-QUINAZOLINE-4,6-DIAMINE; N4-(3,4-Difluorophenyl)-7-methoxyquinazoline-4,6-diamine (Dacomitinib Impurity). Grades: ≥95%. CAS No. 2117703-26-9. Molecular formula: C15H12F2N4O. Mole weight: 302.28. | |
| Dacomitinib Impurity SFXJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. CAS No. 2119689-75-5. Molecular formula: C15H10F2N4O3. Mole weight: 332.26. | |
| Dacomitinib Impurity SL | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H25Cl2N5O2. Mole weight: 486.40. | |
| Dacomitinib Impurity SLAJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C15H12Cl2N4O. Mole weight: 335.19. | |
| Dacomitinib Impurity SLXJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C15H10Cl2N4O3. Mole weight: 365.17. | |
| Dacomitinib Impurity WZYG | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H25ClFN5O2. Mole weight: 469.95. | |
| Dacomitinib Impurity WZYGAJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C15H12ClFN4O. Mole weight: 318.74. | |
| Dacomitinib Impurity WZYGXJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C15H10ClFN4O3. Mole weight: 348.72. | |
| 1-(4-((3-Chloro-4-fluorocyclohexyl)amino)-7-methoxyquinazolin-6-yl)-5-hydroxypyrrolidin-2-one | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: 2-Pyrrolidinone, 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-5-hydroxy-; Dacomitinib Impurity WYQJ. Grades: ≥95%. CAS No. 2190490-31-2. Molecular formula: C19H16ClFN4O3. Mole weight: 402.81. | |
| N-(3-chloro-2-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinamine | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: Dacomitinib Impurity 2F3LXJ. Grades: ≥95%. CAS No. 1454307-45-9. Molecular formula: C15H10ClFN4O3. Mole weight: 348.72. | |
| N4-(3-chloro-2-fluorophenyl)-7-methoxy-4,6-quinazolinediamine | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: Dacomitinib Impurity 2F3LAJ. Grades: ≥95%. CAS No. 1221892-23-4. Molecular formula: C15H12ClFN4O. Mole weight: 318.73. | |
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