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DBZ, also called dibenzazepine, is a γ-secretase inhibitor to treat Alzheimer's Disease, and it also inhibits Notch signaling. Synonyms: YO-01027; YO 01027; YO01027; (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide; dibenzazepine; GSI XX; Dibenzazepine; 209984-56-5; YO-01027; (S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide; Deshydroxy LY 411575; gamma-Secretase Inhibitor XX; DBZ; 209984-56-5 pound not YO 010. Grade: >98%. CAS No. 209984-56-5. Molecular formula: C26H23F2N3O3. Mole weight: 463.48.
DBZ
DBZ. Group: Biochemicals. Grades: Purified. CAS No. 209984-56-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
DBzA
DBzA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-Methyl-2-(4-(9-(4-(6-methylbenzo[d ]thiazol-2-yl)phenyl)anthracen-10-yl)phenyl)benzo[d ]thiazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 850018-19-8. Molecular formula: C42H28N2S2. Mole weight: 624.82 g/mol. Product ID: ACM850018198. Alfa Chemistry ISO 9001:2015 Certified.
A cell-permeable dibenzazepine (dbz) compound that acts as a potent y-secretase inhibitor and significantly lowers both brain and plasma AB40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100umol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50=1.7nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10umol/kg, i.p). CAS Number:209984-56-5. Group: Biochemicals. Grades: Highly Purified. CAS No. 209984-56-5. Pack Sizes: 500ug, 1mg. US Biological Life Sciences.