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| Product | Description | |
|---|---|---|
| DCPIB | DCPIB. Group: Biochemicals. Grades: Purified. CAS No. 82749-70-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| DCPIB | DCPIB is a potent and selective volume-sensitive anion channel (VSAC) blocker, swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells). It inhibits glucose-stimulated insulin in intact β-cells, and reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Synonyms: 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid. Grade: ≥98% by HPLC. CAS No. 82749-70-0. Molecular formula: C22H28Cl2O4. Mole weight: 427.37. |  |
| DCPIB | DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1 and TASK3 (IC50s: 0.14, 0.95, 50.72 ?M, respectively). DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 ?M. DCPIB is a useful tool for investigating structure-function studies of K2P channels[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 82749-70-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103371. |  |
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