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DDD85646 DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. Synonyms: IMP-366; 2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide. Grades: ≥98%. CAS No. 1215010-55-1. Molecular formula: C21H24Cl2N6O2S. Mole weight: 495.4. BOC Sciences 9
DDD85646 DDD85646 is a T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. DDD85646 has potent activity against the enzyme (IC(50) = 2 nM) and T. brucei (EC(50) = 2 nM) in culture. DDD85646 has good oral pharmacokinetics and cures rodent models of peripheral HAT infection. DDD85646 provides an excellent tool for validation of T. brucei NMT as a drug target for HAT as well as a valuable lead for further optimization. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DDD85646; DDD-85646; DDD 85646. Product Category: Others. Appearance: Solid powder. CAS No. 1215010-55-1. Molecular formula: C21H24Cl2N6O2S. Mole weight: 495.42. Purity: >98%. IUPACName: 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide. Canonical SMILES: O=S(C1=C(Cl)C=C(C2=CC(N3CCNCC3)=NC=C2)C=C1Cl)(NC4=C(C)N(C)N=C4C)=O. Product ID: ACM1215010551. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.

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