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| Product | Description | |
|---|---|---|
| Debio 0932 | Debio 0932, also known as CUDC-305, is a novel Hsp90 inhibitor with strong affinity for Hsp90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. Furthermore, Debio 0932 is able to extend animal survival in models of brain metastasis due to its ability to cross the blood-brain barrier, and it enhances the activity of several standard-of-care agents in animal models of cancer. Synonyms: Debio0932; Debio 0932; CUDC-305; CUDC305; CUDC 305. Grades: >98%. CAS No. 1061318-81-7. Molecular formula: C22H30N6O2S. Mole weight: 442.58. |  |
| Debio 0932 | Debio 0932 (CUDC-305) is an orally active HSP90 inhibitor, with IC 50 s of 100 and 103 nM for HSP90α and HSP90β, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CUDC-305. CAS No. 1061318-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13469. |  |
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