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| Product | Description | |
|---|---|---|
| Derazantinib | Derazantinib (ARQ-087) is an ATP competitive and orally active FGFR inhibitor ( IC 50 s: 1.8 nM for FGFR2, 4.5 nM for FGFR1 and 3 nM). Derazantinib inhibits FGFR phosphorylation. Derazantinib inhibits tumor growth in multiple xenograft models [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARQ-087. CAS No. 1234356-69-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19981. |  |
| Derazantinib dihydrochloride | Derazantinib is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation of key cellular behaviors including proliferation, cell differentiation and so on. FGFR dysregulation is considered as a driver in multiple cancers. Derazantinib binds to FGFR and effectively inhibits the activation of FGFR thus can suppress tumorigenesis and tumor growth. Synonyms: Derazantinib hydrochloride; ARQ-087 dihydrochloride; ARQ-087 hydrochloride; ARQ-087 2HCl; ARQ 087 2HCl. CAS No. 1821329-75-2. Molecular formula: C29H31Cl2FN4O. Mole weight: 541.49. |  |
| Derazantinib Racemate | Derazantinib Racemate (ARQ-087 Racemate) is the racemate of Derazantinib. Derazantinib is an orally bioavailable, ATP competitive tyrosine kinase inhibitor; exhibits potent activity against FGFR1-3 chondrocytes with IC 50 s of 4.5, 1.8, and 4.5 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARQ-087 Racemate. CAS No. 2309668-44-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 2 mg. Product ID: HY-19981A. | |
| ARQ-087 | ARQ-087, also known as Derazantinib, is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation of key cellular behaviors including proliferation, cell differentiation and so on. FGFR dysregulation is considered as a driver in multiple cancers. ARQ 087 binds to FGFR and effectively inhibits the activation of FGFR thus can suppress tumorigenesis and tumor growth. Synonyms: ARQ 087; ARQ087; ARQ-087; Derazantinib; (6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine. Grades: ≥98%. CAS No. 1234356-69-4. Molecular formula: C29H29FN4O. Mole weight: 468.576. | |
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