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| Product | Description | |
|---|---|---|
| Deruxtecan | Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC). Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. Synonyms: Deruxtecan Analog; Deruxtecan, Trastuzumab deruxtecan; DS-8201a; DS8201a; DS 8201a; Exatecan derivative; DX-8951 derivative; DX 8951; DX8951; N-[6-(2, 5-Dioxo-2, 5-dihydro-1H-pyrrol-1-yl)hexanoyl]glycylglycyl-L-phenylalanyl-N-[(2-{[(1S, 9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10, 13-dioxo-2, 3, 9, 10, 13, 15-hexahydro-1H, 12H-benzo[de]pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-1-yl]amino}-2-oxoethoxy)methyl]glycinamide. Grades: ≥95%. CAS No. 1599440-13-7. Molecular formula: C52H56FN9O13. Mole weight: 1034.05. |  |
| Deruxtecan | Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Deruxtecan, Trastuzumab deruxtecan; DS-8201a; DS8201a; DS 8201a; exatecan derivative; DX-8951 derivative; DX 8951; DX8951. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1599440-13-7. Molecular formula: C52H56FN9O13. Mole weight: 1034.07. Purity: >98%. IUPACName: Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12Hbenzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-. Canonical SMILES: CC[C@@]1(O)C(OCC2=C1C=C3N(C2=O)CC(C3=NC4=CC(F)=C5C)=C6C4=C5CC[C@@H]6NC(COCNC(CNC([C@@H](NC(CNC(CNC(CCCCCN7C(C=CC7=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O. Product ID: ACM1599440137. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Deruxtecan | Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MC-GGFG-DXD. CAS No. 1599440-13-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13631E. |  |
| (1R)-Deruxtecan | (1R)-Deruxtecan is a drug-linker conjugates for ADC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2270986-87-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-13631O. | |
| Datopotamab deruxtecan | Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS-1062; Dato-DXd. CAS No. 2238831-60-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141598. | |
| Ifinatamab deruxtecan | Ifinatamab deruxtecan (DS-7300a) is an ADC that binds an anti-B7-H3 antibody to the DNA topoisomerase I inhibitory anti-tumor drug DXd. Ifinatamab deruxtecan has antitumor activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: DS-7300a; MABX-9001a. CAS No. 2484870-92-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3371. | |
| Patritumab deruxtecan | Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HER3-DXd; U3-1402. CAS No. 2227102-46-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99813. | |
| Trastuzumab deruxtecan | Trastuzumab deruxtecan (DS-8201a) is an anti- human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS-8201; DS-8201a. CAS No. 1826843-81-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-138298A. | |
| Trastuzumab deruxtecan (solution) | Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti- human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS-8201 (solution); DS-8201a (solution). CAS No. 1826843-81-5. Pack Sizes: 1 mg (10 mg/mL * 100 μL in Aqueous solution); 5 mg (10 mg/mL * 500 μL in Aqueous solution). Product ID: HY-138298. | |
| Datopotamab | Datopotamab (CDP7657) is a humanized anti trophoblast cell surface antigen 2 ( TROP2 ) antibody. Datopotamab can generate antibody drug conjugates (ADC) (HY-141598) with DNA topoisomerase I inhibitor Deruxtecan (HY-13631E). Datopotamab can be used in the study of triple negative breast cancer and non-small cell lung cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2267989-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99843. | |
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