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| Product | Description | |
|---|---|---|
| DG2 | DG2 is a potent and selective inhibitor of p70 ribosomal S6 kinase 1 (S6K1) (IC50 = 9.1 nM) with ATP-competitive and cell-permeable properties. Synonyms: S6K1 Inhibitor DG2; S6K1-Inhibitor-DG2; S6K1InhibitorDG2; S6K1-IN-DG2; S6K1 IN DG2; S6K1INDG2; 3-Bromo-4-(4-(2-methoxyphenyl)piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine. Grades: 99%. CAS No. 871340-88-4. Molecular formula: C16H17BrN6O. Mole weight: 389.25. |  |
| S6K1 Inhibitor II, DG2 (3-Bromo-4- (4- (2-methoxyphenyl) piperazin-1-yl) -1H-pyrazolo[3, 4-d]-pyrimidine) | A cell-permeable pyrazolopyrimidine compound that acts as a potent, ATP-competitive and reversible inhibitor of S6K1 (p70 ribosomal protein S6 kinase 1; IC50=9.1nM) with ~2,400 reduced activity towards Akt (IC50=22uM). Shown to completely block rpS6-Ser240/244 phosphorylation in L6 cells at 2.5uM without inducing pAkt-Thr308 and Ser473, and display substantial selectivity in a 219-kinase panel (1uM of DG2 in the presence of 10uM of ATP; IC50 ≥50%; Clk1, Clk2, Dyrk1A, Dyrk3, Flt3, Flt3-D835Y, Flt4, GSK-3a/b, R, MAP4K4, Mink1, PKA, PRKG1, PRKG2, Ret-V804L, Ret-Y791F, RSK1, RSK3, RSK2, MSK2, MSK1 and p70S6K). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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