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2-Hydroxy-5-dibenzosuberone 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences.
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3-Methoxy Dibenzosuberone
2,3:6,7-Dibenzosuberan derivative. Intermediate in the preparation of pharmaceutically active Dibenzocycloheptenes. An antidepressant. Group: Biochemicals. Alternative Names: 3-Methoxy Dibenzocycloheptenone; 3-Methoxy Dibenzosuberan-5-one; 3-Methoxy-10, 11-dihydro-5H-dibenzo[a, d]cyclohepten-5-one; 10, 11-Dihydro-3-methoxy-5H-dibenzo[a, d]cyclohepten-5-one. Grades: Highly Purified. CAS No. 17910-76-8. Pack Sizes: 5mg. US Biological Life Sciences.
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5-Dibenzosuberone ≥98.5%
5-Dibenzosuberone ≥98.5%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 1210-35-1. Pack Sizes: 5g, 25g, 100g, 250g, 1Kg. US Biological Life Sciences.
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Amitriptyline Impurity A
Amitriptyline Related Compound. Synonyms: Dibenzosuberone. Grades: > 95%. CAS No. 1210-35-1. Molecular formula: C15H12O. Mole weight: 208.26.
A cell-permeable phenylamino-dibenzosuberone-diol with a rigid molecular structure specifically designed to target hydrophobic region I in p38alpha & p38beta, but not in other kinases with bulky entrance-blocking gatekeeper residues. Shown to selectively inhibit p38alpha (IC50 = 5nM; [ATP] = 100uM) and p38beta (97% inhibition at 1uM), while exhibiting little affinity toward 400 other kinase constructs, including p38delta, p38upsilon, Erk1/2/3/4/5/8, JNK1/2/3, and MEK1/2/3/4/6. Shown to prevent cellular HSP27 Ser82 phosphorylation upon p38 activation by Anisomycin in HeLa (IC50 = 25nM) or by TNF-alpha in THP-1 cultures. Unlike the ATP-binding site-targeting BIRB 796 and SB 203580, Skepinone-L does not inhibit JNK-mediated c-Jun or ERK-dependent CREB phosphorylation in THP-1 cultures. Oral administration to D-Gal-sensitized mice is reported to greatly reduce plasma TNF-alpha production upon LPS challenge (by 77%; 3mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
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