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2,6-Dichloroanisole is used as a reagent in the synthesis of the potent antineoplastic agent, Deoxynyboquinone. 2,6-Dichloroanisole is also used as a reagent in the preparation of naphthyridinone, pyrimidinone, and oxazinone derivatives for treatment of schizophrenia, other mental disorders, and central nervous system disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 1984-65-2. Pack Sizes: 5g, 10g. Molecular Formula: C7H6Cl2O, Molecular Weight: 177.03. US Biological Life Sciences.
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Malaridine Impurity 2
Malaridine Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 7,10-dichlorobenzo[b][1,5]naphthyridin-2(1H)-one. Molecular Formula: C12H6Cl2N2O. Mole Weight: 265.09. Catalog: APB01473.
OTSSP167
OTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells. MELK, a serine/threonine kinase, is involved in cancer cell survival, invasiveness and cancer-stem cell formation and maintenance; it is highly upregulated in various types of cancer cells and absent in normal, healthy cells. Synonyms: 1- (6- (3, 5-dichloro-4-hydroxyphenyl) -4- ( ( (1r, 4r) -4- ( (dimethylamino) methyl) cyclohexyl) amino) -1, 5-naphthyridin-3-yl) ethanone; OTSSP167 free base; OTSSP 167; OTSSP-167; OTS167; OTS-167; OTS 167. Grades: 0.98. CAS No. 1431697-89-0. Molecular formula: C25H28Cl2N4O2. Mole weight: 487.425.
OTSSP167 hydrochloride
OTSSP167 is a potent inhibitor of Maternal embryonic leucine zipper kinase (MELK) which regulates neural stem cell selfrenewal through control of the cell cycle. Synonyms: 4-[7-acetyl-8-[[4-[ (dimethylamino) methyl]cyclohexyl]amino]-1H-1, 5-naphthyridin-2-ylidene]-2, 6-dichlorocyclohexa-2, 5-dien-1-one hydrochloride; OTSSP167 (hydrochloride); UNII-65P731R507; 65P731R507; OTSSP167 HCl; OTS-167 monohydrochloride; HY-15512A; AKOS025117447. CAS No. 1431698-10-0. Molecular formula: C25H29Cl3N4O2. Mole weight: 523.9.
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