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2,3-Difluoroaniline is part of a group of halogenated anilines that are capable of inhibiting human cytochrome P450 2E1, ultimately affecting the metabolism of xenobiotics in the body. Group: Biochemicals. Grades: Highly Purified. CAS No. 4519-40-8. Pack Sizes: 1g, 5g. Molecular Formula: C6H5F2N, Molecular Weight: 129.11. US Biological Life Sciences.
Worldwide
2,4-Dibromo-3,6-difluoroaniline
2,4-Dibromo-3,6-difluoroaniline. Group: Biochemicals. Grades: Highly Purified. CAS No. 1000577-86-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H3Br2F2N, Molecular Weight: 286.899999999999. US Biological Life Sciences.
Worldwide
2,4-Dichloro-3,5-difluoroaniline
2,4-Dichloro-3,5-difluoroaniline. Group: Biochemicals. Grades: Highly Purified. CAS No. 50408-95-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H3Cl2F2N, Molecular Weight: 198. US Biological Life Sciences.
Worldwide
2,4-Difluoroaniline
2,4-Difluoroaniline. Group: Biochemicals. Grades: Highly Purified. CAS No. 367-25-9. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C6H5F2N. US Biological Life Sciences.
Worldwide
2,5-Difluoroaniline
2,5-Difluoroaniline. Group: Biochemicals. Grades: Highly Purified. CAS No. 367-30-6. Pack Sizes: 500mg, 1g. Molecular Formula: C6H5F2N, Molecular Weight: 129.11. US Biological Life Sciences.
Worldwide
2,6-Difluoroaniline
2,6-Difluoroaniline. Group: Biochemicals. Grades: Highly Purified. CAS No. 5509-65-9. Pack Sizes: 25g, 50g, 100g, 250g, 500g. US Biological Life Sciences.
2, 4-Difluoro-6- (trifluoromethyl) benzenamine Hydrochloride is a derivative compound of 2,4-Difluoroaniline (367-25-9), used in the synthesis and cytotoxic activity evaluation of novel piperazine-quinoline derivatives on breast cancer cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 1240526-71-9. Pack Sizes: 500mg, 1g. Molecular Formula: C7H4F5N; HCl, Molecular Weight: 197.113645999999. US Biological Life Sciences.
BMS 299897, under the IUPAC name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid, synthesized by the radiosynthesis group at Bristol-Myers Squibb, is a β-secretase inhibitor that has the potential for treatment of Alzheimer's diseases (IC50 = 12 nM; gamma-secretase express: EC50 = 7 nM (CHO cells)). BMS 299897 blocks the formation of Aβ40 (IC50 = 7.9 nM) and Aβ42 (IC50 = 7.9 nM) in the brain, and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Synonyms: 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid; 4-(2-((1R)-1-(((4-chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic acid; BMS299897; BMS 299897; BMS-299897; 290315-45-6; 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid; C24H21ClF3NO4S; CHEMBL247471; SCHEMBL6394108; DTXSID50460039; 3496AH; ZINC28883606; AKOS024457319; CCG-222540; CS-1339; NCGC00346875-01; HY-50883; KB-75603; DB-017854; W-5550; BRD-K02950022-001-01-1; 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoic acid; BMS 299897|2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid. CAS No. 290315-45-6. Molecular formula: C24H21ClF3NO4S. Mole weight: 511.94.
An orally bioavailable sulfonamide compound that acts as a potent, reversible and allosteric y-secretase activity inhibitor with ~15-fold greater selectivity over Notch-1 proteolysis processing (IC50=7.1 and 105.9nM in HEK293-wtAPP) and preferentially inhibits PS1 (presenillin 1)-comprised y-secretase (EC50=8, 108, 286 and 29nM for PS1, Triple PS1-L172M,T281P, L282I, PS2 and Triple PS2-M178L, P287T, I288L), respectively). Shown to reduce the levels of Ab38, Ab40 and Ab42 in Tg2576 mice, Ab40 brain and plasma in APP-YAC mice (ED50=30 and 16mg/kg, p.o.) and Abtotal brain, CSF and plasma in guinea pigs (ED50=30mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 290315-45-6. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
CHZ868
CHZ868 is a potent and selective type II JAK2 inhibitor (IC50 = 0.17 μM in EPOR JAK2 WT Ba/F3 cell). CHZ868 potently inhibited proliferation of cells expressing the JAK2V617F mutation or the TEL-JAK2 fusion. Synonyms: Acetamide, N-[4-[[2-[(2,4-difluorophenyl)amino]-1,4-dimethyl-1H-benzimidazol-5-yl]oxy]-2-pyridinyl]-; N-(4-{[2-(2,4-difluoroanilino)-1,4-dimethyl-1H-benzimidazol-5-yl]oxy}pyridin-2-yl)acetamide; N-[4-[2-[[2,4-bis(fluoranyl)phenyl]amino]-1,4-dimethyl-benzimidazol-5-yl]oxypyridin-2-yl]ethanamide. Grades: 98%. CAS No. 1895895-38-1. Molecular formula: C22H19F2N5O2. Mole weight: 423.42.
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