Dihydro Methylthieno Suppliers USA
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Product | Description | |
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2,4-Dimethyloxazole Quick inquiry Where to buy Suppliers range | 2,4-Dimethyloxazole. Group: Heterocyclic Organic Compound. Alternative Names: kahweofuran; TomatoLycopene; Spicery; 2, 3-Dihydro-6-methylthieno[2, 3-c]furan; 6-Methyl-2, 3-dihydrothieno[2, 3-c]furan; N-Piperidinyl-3-Methylthio-1-propene. CAS No. 26693-24-3. Molecular formula: C5H7OS. Mole weight: 140.2. Boiling Point: 193?. Flash Point: 70?. Density: 1.197. | |
p21-Activated Kinase Inhibitor II, PF-3758309 (PAK Inhibitor II, PF3758309, (S)-N-(2-(Dimethylamino)-1-phenylethyl)-6,6-dimethyl-3-(2-methylthieno[3,2-d]pyrimidin-4-ylamino)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrrolopyrazole that acts as a potent inhibitor against p21-activated kinases (Ki innM/[ATP] inuM = 13.7/200, 18.7/40, 18.1/80. 17.1/72, respectively, in PAK1, PAK4, PAK5, PAK6 kinase assays; IC50 = 190 and 99nM against PAK1 and PAK3, respectively) by directly targeting the kinase ATP-binding site in a reversible manner (Kd = 4.5nM using rhPAK4300-591 kinase domain). Inhibits PAK4-dependent cellular signaling (IC50 = 24.2nM against TNFalpha-stimulated NF-kappa-B activity in HEK293T) and proliferation (IC50 = 0.24 and 27nM, respectively, against HCT116 and A549 colonies formation) in vitro and the growth of human tumors in nude mice in vivo (10 to 25mg/kg; b.i.d. p.o). Group: Biochemicals. Grades: Highly Purified. CAS No. 898044-15-0. Pack Sizes: 5mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
PF 3758309 dihydrochloride Quick inquiry Where to buy Suppliers range | PF 3758309 dihydrochloride is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 (IC50 = 1.3 nM; Kd = 2.7 nM). PF 3758309 inhibits phosphorylation of a natural PAK4 substrate in cells with an IC50 ~1 nM and inhibits anchorage-independent growth (expected biology for PAK4 inhibition) at 240 pM. Synonyms: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride; PF 3758309 dihydrochloride; PF3758309 dihydrochloride; PF-3758309 dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C25H30N8OS.2HCl. Mole weight: 563.55. |